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    Mtrr 5-methyltetrahydrofolate-homocysteine methyltransferase reductase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 290947, updated on 9-Dec-2024

    Summary

    Official Symbol
    Mtrrprovided by RGD
    Official Full Name
    5-methyltetrahydrofolate-homocysteine methyltransferase reductaseprovided by RGD
    Primary source
    RGD:1308671
    See related
    EnsemblRapid:ENSRNOG00000017826 AllianceGenome:RGD:1308671
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    MSR
    Summary
    Predicted to enable NADPH-hemoprotein reductase activity; [methionine synthase] reductase (NADPH) activity; and nucleotide binding activity. Predicted to be involved in several processes, including folic acid metabolic process; negative regulation of cystathionine beta-synthase activity; and sulfur amino acid metabolic process. Predicted to be located in intermediate filament cytoskeleton and nucleoplasm. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in several diseases, including abdominal aortic aneurysm; endocrine gland cancer (multiple); heart disease (multiple); hematologic cancer (multiple); and homocystinuria. Orthologous to human MTRR (5-methyltetrahydrofolate-homocysteine methyltransferase reductase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 120.0), Muscle (RPKM 107.4) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Mtrr in Genome Data Viewer
    Location:
    1p11
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (36695376..36727341)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (34866991..34899425)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (37743089..37774485)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene cilia and flagella associated protein 90 Neighboring gene FAST kinase domains 3 Neighboring gene uncharacterized LOC134482589 Neighboring gene zinc finger protein 455 like 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    General gene information

    Clone Names

    • MGC112912

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables FAD binding  
    enables FMN binding  
    enables FMN binding  
    enables FMN binding  
    enables NADPH binding  
    enables NADPH-hemoprotein reductase activity  
    enables [methionine synthase] reductase (NADPH) activity  
    enables [methionine synthase] reductase (NADPH) activity  
    enables flavin adenine dinucleotide binding  
    enables flavin adenine dinucleotide binding  
    enables flavin adenine dinucleotide binding  
    enables oxidoreductase activity  
    enables oxidoreductase activity, acting on metal ions, NAD or NADP as acceptor  
    enables oxidoreductase activity, acting on metal ions, NAD or NADP as acceptor  
    Process Evidence Code Pubs
    involved_in S-adenosylmethionine cycle  
    involved_in biological_process  
    involved_in cobalamin metabolic process  
    involved_in folic acid metabolic process  
    involved_in folic acid metabolic process  
    involved_in homocysteine catabolic process  
    involved_in homocysteine metabolic process  
    involved_in homocysteine metabolic process  
    involved_in methionine biosynthetic process  
    involved_in methionine biosynthetic process  
    involved_in methionine biosynthetic process  
    involved_in negative regulation of cystathionine beta-synthase activity  
    Component Evidence Code Pubs
    is_active_in cytosol  
    is_active_in cytosol  
    located_in cytosol  
    located_in intermediate filament cytoskeleton  
    located_in intermediate filament cytoskeleton  
    located_in nucleoplasm  
    located_in nucleoplasm  

    General protein information

    Preferred Names
    methionine synthase reductase
    Names
    aqCbl reductase
    aquacobalamin reductase
    NP_001034092.1
    XP_006227875.1
    XP_006227876.1
    XP_038958809.1
    XP_038958835.1
    XP_063138780.1
    XP_063138782.1
    XP_063138783.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039003.1NP_001034092.1  methionine synthase reductase

      See identical proteins and their annotated locations for NP_001034092.1

      Status: PROVISIONAL

      Source sequence(s)
      BC100107
      UniProtKB/Swiss-Prot
      Q498R1
      Related
      ENSRNOP00000058505.2, ENSRNOT00000061790.5
      Conserved Domains (3) summary
      cd06203
      Location:84505
      methionine_synthase_red; Human methionine synthase reductase (MSR) restores methionine sythase which is responsible for the regeneration of methionine from homocysteine, as well as the coversion of methyltetrahydrofolate to tetrahydrofolate. In MSR, electrons are transferred ...
      COG0369
      Location:90505
      CysJ; Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]
      pfam00258
      Location:646
      Flavodoxin_1; Flavodoxin

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      36695376..36727341
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006227813.5XP_006227875.1  methionine synthase reductase isoform X1

      See identical proteins and their annotated locations for XP_006227875.1

      UniProtKB/Swiss-Prot
      D3ZDG8, Q498R1
      UniProtKB/TrEMBL
      A0A8L2QCU1
      Related
      ENSRNOP00000024041.4, ENSRNOT00000024041.7
      Conserved Domains (2) summary
      cd06203
      Location:278699
      methionine_synthase_red; Human methionine synthase reductase (MSR) restores methionine sythase which is responsible for the regeneration of methionine from homocysteine, as well as the coversion of methyltetrahydrofolate to tetrahydrofolate. In MSR, electrons are transferred ...
      pfam00258
      Location:6142
      Flavodoxin_1
    2. XM_063282712.1XP_063138782.1  methionine synthase reductase isoform X4

    3. XM_063282710.1XP_063138780.1  methionine synthase reductase isoform X1

      UniProtKB/Swiss-Prot
      D3ZDG8, Q498R1
      UniProtKB/TrEMBL
      A0A8L2QCU1
    4. XM_063282713.1XP_063138783.1  methionine synthase reductase isoform X5

      UniProtKB/TrEMBL
      A0A8L2QCU1
    5. XM_039102881.2XP_038958809.1  methionine synthase reductase isoform X2

      UniProtKB/TrEMBL
      A0A8L2QCU1
      Conserved Domains (2) summary
      cd06203
      Location:224645
      methionine_synthase_red; Human methionine synthase reductase (MSR) restores methionine sythase which is responsible for the regeneration of methionine from homocysteine, as well as the coversion of methyltetrahydrofolate to tetrahydrofolate. In MSR, electrons are transferred ...
      pfam00258
      Location:288
      Flavodoxin_1
    6. XM_006227814.4XP_006227876.1  methionine synthase reductase isoform X3

      See identical proteins and their annotated locations for XP_006227876.1

      UniProtKB/TrEMBL
      A0A8L2QCU1
      Conserved Domains (1) summary
      cd06203
      Location:155576
      methionine_synthase_red; Human methionine synthase reductase (MSR) restores methionine sythase which is responsible for the regeneration of methionine from homocysteine, as well as the coversion of methyltetrahydrofolate to tetrahydrofolate. In MSR, electrons are transferred ...
    7. XM_039102907.2XP_038958835.1  methionine synthase reductase isoform X5

      UniProtKB/TrEMBL
      A0A8L2QCU1
      Conserved Domains (1) summary
      cd06203
      Location:116537
      methionine_synthase_red; Human methionine synthase reductase (MSR) restores methionine sythase which is responsible for the regeneration of methionine from homocysteine, as well as the coversion of methyltetrahydrofolate to tetrahydrofolate. In MSR, electrons are transferred ...
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