U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    Man1a1 mannosidase, alpha, class 1A, member 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 294410, updated on 9-Dec-2024

    Summary

    Official Symbol
    Man1a1provided by RGD
    Official Full Name
    mannosidase, alpha, class 1A, member 1provided by RGD
    Primary source
    RGD:1310891
    See related
    EnsemblRapid:ENSRNOG00000000800 AllianceGenome:RGD:1310891
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Man1a; Aa2-166
    Summary
    Predicted to enable mannosyl-oligosaccharide 1,2-alpha-mannosidase activity. Predicted to be involved in mannose trimming involved in glycoprotein ERAD pathway and protein targeting to ER. Predicted to be located in several cellular components, including Golgi apparatus; cytosol; and endoplasmic reticulum-Golgi intermediate compartment. Predicted to be active in Golgi membrane and endoplasmic reticulum. Orthologous to human MAN1A1 (mannosidase alpha class 1A member 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 548.2), Adrenal (RPKM 498.1) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Man1a1 in Genome Data Viewer
    Location:
    20q11
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (33745158..33928584, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (33202509..33385747, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (35257688..35450132, complement)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA26 Neighboring gene family with sequence similarity 184, member A Neighboring gene uncharacterized LOC120098964 Neighboring gene tubulin, alpha 1B, pseudogene 10 Neighboring gene CD46 molecule like 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in ERAD pathway  
    involved_in ERAD pathway  
    involved_in carbohydrate metabolic process  
    involved_in mannose trimming involved in glycoprotein ERAD pathway  
    involved_in protein targeting to ER  
    Component Evidence Code Pubs
    located_in Golgi apparatus  
    is_active_in Golgi membrane  
    located_in Golgi membrane  
    located_in cytoplasmic vesicle  
    located_in cytosol  
    located_in cytosol  
    is_active_in endoplasmic reticulum  
    located_in endoplasmic reticulum-Golgi intermediate compartment  

    General protein information

    Preferred Names
    mannosyl-oligosaccharide 1,2-alpha-mannosidase IA
    Names
    mannosidase 1, alpha
    mannosyl-oligosaccharide alpha-1,2-mannosidase
    NP_001028828.1
    XP_006256559.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033656.1NP_001028828.1  mannosyl-oligosaccharide 1,2-alpha-mannosidase IA

      See identical proteins and their annotated locations for NP_001028828.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000020
      UniProtKB/TrEMBL
      A0A0G2JW29, A6K4A2, G3V9N9
      Related
      ENSRNOP00000054231.1, ENSRNOT00000057422.4
      Conserved Domains (1) summary
      pfam01532
      Location:204642
      Glyco_hydro_47; Glycosyl hydrolase family 47

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      33745158..33928584 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006256497.3XP_006256559.1  mannosyl-oligosaccharide 1,2-alpha-mannosidase IA isoform X1

      UniProtKB/TrEMBL
      A0A0G2JW29, A0A8I5ZJA7
      Related
      ENSRNOP00000076820.1, ENSRNOT00000101500.2
      Conserved Domains (1) summary
      pfam01532
      Location:295733
      Glyco_hydro_47; Glycosyl hydrolase family 47
    External link. Please review our privacy policy.