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    Noc3l NOC3-like DNA replication regulator [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361753, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Noc3lprovided by RGD
    Official Full Name
    NOC3-like DNA replication regulatorprovided by RGD
    Primary source
    RGD:1560656
    See related
    EnsemblRapid:ENSRNOG00000013965 AllianceGenome:RGD:1560656
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1560656
    Summary
    Predicted to enable chromatin binding activity. Predicted to be involved in DNA replication initiation. Predicted to act upstream of or within fat cell differentiation. Predicted to be located in mitochondrion and nuclear speck. Predicted to be active in nucleolus. Orthologous to human NOC3L (NOC3 like DNA replication regulator). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 103.7), Spleen (RPKM 93.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Noc3l in Genome Data Viewer
    Location:
    1q53
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (245969179..245997761, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (236556037..236585372, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (257469538..257498844, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134485233 Neighboring gene phospholipase C, epsilon 1 Neighboring gene selenophosphate synthetase 1, pseudogene 1 Neighboring gene TBC1 domain family, member 12 Neighboring gene uncharacterized LOC134483995

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Fad24, a mammalian homolog of Noc3p, is a positive regulator in adipocyte differentiation. Tominaga K, et al. J Cell Sci, 2004 Dec 1. PMID 15564382
    2. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889
    3. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Castello A, et al. Cell, 2012 Jun 8. PMID 22658674
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA replication initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within fat cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    nucleolar complex protein 3 homolog
    Names
    nucleolar complex associated 3 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108523.1 → NP_001101993.1  nucleolar complex protein 3 homolog

      See identical proteins and their annotated locations for NP_001101993.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473953
      UniProtKB/TrEMBL
      A0A8I6AC09, A6I192, D4AB23
      Related
      ENSRNOP00000019056.4, ENSRNOT00000019056.7
      Conserved Domains (3) summary
      COG5117
      Location:113 → 712
      NOC3; Protein involved in the nuclear export of pre-ribosomes [Translation, ribosomal structure and biogenesis / Intracellular trafficking and secretion]
      pfam03914
      Location:554 → 707
      CBF; CBF/Mak21 family
      pfam07540
      Location:213 → 307
      NOC3p; Nucleolar complex-associated protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      245969179..245997761 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063268665.1 → XP_063124735.1  nucleolar complex protein 3 homolog isoform X1

    RNA

    1. XR_005489086.2 RNA Sequence

    2. XR_010055154.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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