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    Fem1b fem-1 homolog B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 315745, updated on 9-Dec-2024

    Summary

    Official Symbol
    Fem1bprovided by RGD
    Official Full Name
    fem-1 homolog Bprovided by RGD
    Primary source
    RGD:1304569
    See related
    EnsemblRapid:ENSRNOG00000007077 AllianceGenome:RGD:1304569
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable death receptor binding activity and ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in regulation of signal transduction; regulation of ubiquitin-protein transferase activity; and ubiquitin-dependent protein catabolic process via the C-end degron rule pathway. Predicted to act upstream of or within branching involved in prostate gland morphogenesis; epithelial cell maturation involved in prostate gland development; and protein ubiquitination. Predicted to be located in cytosol; mitochondrion; and nucleoplasm. Predicted to be part of Cul2-RING ubiquitin ligase complex. Predicted to be active in cytoplasm and nucleus. Orthologous to human FEM1B (fem-1 homolog B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 392.6), Testes (RPKM 354.5) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Fem1b in Genome Data Viewer
    Location:
    8q24
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (72160722..72173996, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (63265301..63278577, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (67695041..67708313, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene integrin subunit alpha 11 Neighboring gene uncharacterized LOC120094185 Neighboring gene uncharacterized LOC120094183 Neighboring gene uncharacterized LOC102546547 Neighboring gene CLN6, transmembrane ER protein Neighboring gene calmodulin-like 4

    Genomic regions, transcripts, and products

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables death receptor binding  
    enables metal ion binding  
    enables ubiquitin-like ligase-substrate adaptor activity  
    enables ubiquitin-like ligase-substrate adaptor activity  
    enables ubiquitin-like ligase-substrate adaptor activity  
    Process Evidence Code Pubs
    involved_in apoptotic process  
    acts_upstream_of_or_within branching involved in prostate gland morphogenesis  
    acts_upstream_of_or_within epithelial cell maturation  
    acts_upstream_of_or_within epithelial cell maturation involved in prostate gland development  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process  
    involved_in protein ubiquitination  
    acts_upstream_of_or_within protein ubiquitination  
    involved_in regulation of DNA damage checkpoint  
    involved_in regulation of DNA damage checkpoint  
    involved_in regulation of extrinsic apoptotic signaling pathway via death domain receptors  
    involved_in regulation of ubiquitin-protein transferase activity  
    involved_in ubiquitin-dependent protein catabolic process via the C-end degron rule pathway  
    involved_in ubiquitin-dependent protein catabolic process via the C-end degron rule pathway  
    Component Evidence Code Pubs
    part_of Cul2-RING ubiquitin ligase complex  
    part_of Cul2-RING ubiquitin ligase complex  
    is_active_in cytoplasm  
    located_in cytoplasm  
    is_active_in cytoplasm  
    located_in cytosol  
    located_in cytosol  
    located_in mitochondrion PubMed 
    located_in nucleoplasm  
    located_in nucleoplasm  
    is_active_in nucleus  
    located_in nucleus  
    located_in nucleus  
    part_of ubiquitin ligase complex  

    General protein information

    Preferred Names
    protein fem-1 homolog B
    Names
    FEM1-beta
    feminization 1 homolog b
    feminization of XX and XO animals 1B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108157.1NP_001101627.1  protein fem-1 homolog B

      See identical proteins and their annotated locations for NP_001101627.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473975
      UniProtKB/Swiss-Prot
      P0C6P7
      UniProtKB/TrEMBL
      A6J586
      Related
      ENSRNOP00000009368.5, ENSRNOT00000009368.8
      Conserved Domains (3) summary
      PHA03095
      Location:475613
      PHA03095; ankyrin-like protein; Provisional
      sd00045
      Location:87118
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:158247
      Ank_2; Ankyrin repeats (3 copies)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      72160722..72173996 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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