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    Cblif cobalamin binding intrinsic factor [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29319, updated on 9-Dec-2024

    Summary

    Official Symbol
    Cblifprovided by RGD
    Official Full Name
    cobalamin binding intrinsic factorprovided by RGD
    Primary source
    RGD:62084
    See related
    EnsemblRapid:ENSRNOG00000021001 AllianceGenome:RGD:62084
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Gif
    Summary
    Enables cobalamin binding activity. Predicted to be involved in cobalamin transport. Predicted to be located in apical plasma membrane; endosome; and microvillus. Predicted to be active in extracellular space. Used to study gastritis. Human ortholog(s) of this gene implicated in congenital intrinsic factor deficiency and pernicious anemia. Orthologous to human CBLIF (cobalamin binding intrinsic factor). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 11.4), Brain (RPKM 4.4) and 7 other tissues See more
    Orthologs
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    Genomic context

    See Cblif in Genome Data Viewer
    Location:
    1q43
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (218030756..218045004)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (208605983..208620231)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (228118048..228132296)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene membrane spanning 4-domains A3 Neighboring gene oocyte secreted protein 2 Neighboring gene syntaxin 3 Neighboring gene mitochondrial ribosomal protein L16 Neighboring gene U6atac minor spliceosomal RNA

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cargo receptor ligand activity  
    enables cargo receptor ligand activity  
    enables cobalamin binding  
    enables cobalamin binding PubMed 
    enables cobalamin binding  
    enables cobalamin binding  
    enables vitamin binding PubMed 
    Process Evidence Code Pubs
    involved_in cobalamin transport  
    involved_in cobalamin transport  
    involved_in cobalamin transport  
    involved_in cobalt ion transport  
    Component Evidence Code Pubs
    located_in apical plasma membrane  
    located_in apical plasma membrane  
    located_in endosome  
    located_in endosome  
    is_active_in extracellular space  
    located_in extracellular space  
    is_active_in extracellular space  
    located_in extracellular space  
    located_in microvillus  
    located_in microvillus  

    General protein information

    Preferred Names
    cobalamin binding intrinsic factor
    Names
    IF
    INF
    gastric intrinsic factor
    intrinsic factor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017162.3NP_058858.1  cobalamin binding intrinsic factor precursor

      See identical proteins and their annotated locations for NP_058858.1

      Status: PROVISIONAL

      Source sequence(s)
      J03577
      UniProtKB/TrEMBL
      A0A0G2JSS6, A6I0A8
      Related
      ENSRNOP00000028507.3, ENSRNOT00000028507.6
      Conserved Domains (1) summary
      pfam01122
      Location:29310
      Cobalamin_bind; Eukaryotic cobalamin-binding protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      218030756..218045004
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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