Cited4 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cited4provided by RGD
Official Full Name: Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4provided by RGD
Primary source: RGD:620113
See related: EnsemblRapid:ENSRNOG00000046607 AllianceGenome:RGD:620113
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Mrg2; MRG-2
Summary: Predicted to enable transcription coactivator activity. Predicted to be involved in response to estrogen. Predicted to act upstream of or within positive regulation of DNA-templated transcription. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Orthologous to human CITED4 (Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 4). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: 5q36

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (139532165..139533056)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (134246936..134247827)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (139597731..139598622)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypic screen quantifying differential regulation of cardiac myocyte hypertrophy identifies CITED4 regulation of myocyte elongation.
Title: Phenotypic screen quantifying differential regulation of cardiac myocyte hypertrophy identifies CITED4 regulation of myocyte elongation.
Cited4 expression follows a 24-hour pattern in the rat pineal gland in which night levels are 100-fold higher than day levels. This increase is driven by norepinephrine-cyclic AMP signaling.
Title: Night/day changes in pineal expression of >600 genes: central role of adrenergic/cAMP signaling.

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General gene information

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Markers

RH143793 (e-PCR)
- UniSTS:233039

RH128558 (e-PCR)
- UniSTS:211866

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables transcription coactivator activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription coactivator activity	ISO Inferred from Sequence Orthology more info
enables transcription coactivator activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in response to estrogen	ISO Inferred from Sequence Orthology more info
involved_in response to estrogen	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cbp/p300-interacting transactivator 4

Names: MSG1-related protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.