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    Sc5d sterol-C5-desaturase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 114100, updated on 9-Dec-2024

    Summary

    Official Symbol
    Sc5dprovided by RGD
    Official Full Name
    sterol-C5-desaturaseprovided by RGD
    Primary source
    RGD:620775
    See related
    EnsemblRapid:ENSRNOG00000065944 AllianceGenome:RGD:620775
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Sc5dl
    Summary
    Enables C-5 sterol desaturase activity and delta7-sterol 5(6)-desaturase activity. Involved in cholesterol biosynthetic process via lathosterol. Is active in endoplasmic reticulum membrane. Orthologous to human SC5D (sterol-C5-desaturase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 1112.9), Brain (RPKM 325.5) and 7 other tissues See more
    Orthologs
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    Genomic context

    See Sc5d in Genome Data Viewer
    Location:
    8q22
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (51526669..51538277, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (42629649..42641257, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (46525406..46537014, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120094128 Neighboring gene uncharacterized LOC108351685 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene tectorin alpha

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Clone Names

    • MGC93101

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum membrane PubMed 
    is_active_in endoplasmic reticulum membrane  
    is_active_in membrane  

    General protein information

    Preferred Names
    lathosterol oxidase
    Names
    C-5 sterol desaturase
    delta(7)-sterol 5-desaturase
    delta(7)-sterol C5(6)-desaturase
    lathosterol 5-desaturase
    sterol-C5-desaturase (ERG3 delta-5-desaturase homolog, S. cerevisiae)-like
    sterol-C5-desaturase (fungal ERG3, delta-5-desaturase) homolog
    sterol-C5-desaturase (fungal ERG3, delta-5-desaturase)-like
    NP_446094.1
    XP_017450895.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053642.2NP_446094.1  lathosterol oxidase

      See identical proteins and their annotated locations for NP_446094.1

      Status: PROVISIONAL

      Source sequence(s)
      BC081704
      UniProtKB/Swiss-Prot
      Q9EQS5
      UniProtKB/TrEMBL
      A6J3S8
      Related
      ENSRNOP00000092291.1, ENSRNOT00000106582.2
      Conserved Domains (1) summary
      COG3000
      Location:40257
      ERG3; Sterol desaturase/sphingolipid hydroxylase, fatty acid hydroxylase superfamily [Lipid transport and metabolism]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      51526669..51538277 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017595406.3XP_017450895.1  lathosterol oxidase isoform X1

      UniProtKB/Swiss-Prot
      Q9EQS5
      UniProtKB/TrEMBL
      A6J3S8
      Conserved Domains (1) summary
      COG3000
      Location:40257
      ERG3; Sterol desaturase/sphingolipid hydroxylase, fatty acid hydroxylase superfamily [Lipid transport and metabolism]
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