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    Map3k14 mitogen-activated protein kinase kinase kinase 14 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360640, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Map3k14provided by RGD
    Official Full Name
    mitogen-activated protein kinase kinase kinase 14provided by RGD
    Primary source
    RGD:1310487
    See related
    EnsemblRapid:ENSRNOG00000003278 AllianceGenome:RGD:1310487
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables protein kinase activity. Involved in protein phosphorylation. Predicted to be located in cytosol; fibrillar center; and nucleoplasm. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human MAP3K14 (mitogen-activated protein kinase kinase kinase 14). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 57.3), Thymus (RPKM 50.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Map3k14 in Genome Data Viewer
    Location:
    10q32.1
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (88665417..88715669, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (88165349..88215558, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (91303428..91353601, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene formin-like 1 Neighboring gene EF-hand calcium binding domain 15 Neighboring gene uncharacterized LOC120095296 Neighboring gene spermatogenesis associated 32 Neighboring gene uncharacterized LOC120095297 Neighboring gene Rho GTPase activating protein 27 Neighboring gene uncharacterized LOC134480883 Neighboring gene pleckstrin homology and RUN domain containing M1 Neighboring gene uncharacterized LOC134480884

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Protective effect of Ginkgolids (A+B) is associated with inhibition of NIK/IKK/IkappaB/NF-kappaB signaling pathway in a rat model of permanent focal cerebral ischemia. Wang X, et al. Brain Res, 2008 Oct 9. PMID 18722355
    2. Overexpressed NF-kappaB-inducing kinase contributes to the tumorigenesis of adult T-cell leukemia and Hodgkin Reed-Sternberg cells. Saitoh Y, et al. Blood, 2008 May 15. PMID 18305221
    3. NF-kappaB-inducing kinase phosphorylates and blocks the degradation of Down syndrome candidate region 1. Lee EJ, et al. J Biol Chem, 2008 Feb 8. PMID 18056702
    4. NF-kappaB-inducing kinase regulates the processing of NF-kappaB2 p100. Xiao G, et al. Mol Cell, 2001 Feb. PMID 11239468
    5. NF-kappaB-inducing kinase activates IKK-alpha by phosphorylation of Ser-176. Ling L, et al. Proc Natl Acad Sci U S A, 1998 Mar 31. PMID 9520446, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. deregulated expression of NIK plays a critical role in constitutive NF-kappaB activation in ATL and H-RS cells
      Title: Overexpressed NF-kappaB-inducing kinase contributes to the tumorigenesis of adult T-cell leukemia and Hodgkin Reed-Sternberg cells.
    2. NF-kappaB-inducing kinase phosphorylates and blocks the degradation of Down syndrome candidate region 1
      Title: NF-kappaB-inducing kinase phosphorylates and blocks the degradation of Down syndrome candidate region 1.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables JUN kinase kinase kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in canonical NF-kappaB signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to mechanical stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in defense response to virus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in non-canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in fibrillar center IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in fibrillar center ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    mitogen-activated protein kinase kinase kinase 14
    NP_001101771.1
    XP_038942345.1
    XP_038942346.1
    XP_038942347.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108301.1 → NP_001101771.1  mitogen-activated protein kinase kinase kinase 14

      See identical proteins and their annotated locations for NP_001101771.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473948
      UniProtKB/TrEMBL
      A6HJQ8, A6HJQ9, D3ZTD1
      Related
      ENSRNOP00000004532.5, ENSRNOT00000004532.7
      Conserved Domains (2) summary
      smart00220
      Location:408 → 667
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd13991
      Location:395 → 662
      STKc_NIK; Catalytic domain of the Serine/Threonine kinase, NF-kappaB Inducing Kinase (NIK)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      88665417..88715669 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039086417.2 → XP_038942345.1  mitogen-activated protein kinase kinase kinase 14 isoform X1

      Conserved Domains (1) summary
      cd13991
      Location:133 → 400
      STKc_NIK; Catalytic domain of the Serine/Threonine kinase, NF-kappaB Inducing Kinase (NIK)

    2. XM_039086419.2 → XP_038942347.1  mitogen-activated protein kinase kinase kinase 14 isoform X3

      Conserved Domains (1) summary
      cl21453
      Location:1 → 192
      PKc_like; Protein Kinases, catalytic domain

    3. XM_039086418.2 → XP_038942346.1  mitogen-activated protein kinase kinase kinase 14 isoform X2

      Conserved Domains (1) summary
      cl21453
      Location:395 → 432
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein Strain
    Heading Accession and Version

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