Tssk2 testis-specific serine kinase 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tssk2provided by RGD
Official Full Name: testis-specific serine kinase 2provided by RGD
Primary source: RGD:1304951
See related: AllianceGenome:RGD:1304951
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Stk22b
Summary: Predicted to enable magnesium ion binding activity and protein serine/threonine kinase activity. Predicted to be involved in peptidyl-serine phosphorylation; protein autophosphorylation; and spermatid development. Predicted to be located in acrosomal vesicle and centriole. Orthologous to human TSSK2 (testis specific serine kinase 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: 11q23

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	11	NC_086029.1 (96590864..96592219, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	11	NC_051346.1 (83086578..83087933, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	11	NC_005110.4 (87235058..87236413, complement)

Chromosome 11 - NC_086029.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Effects of Qilin pills on spermatogenesis, reproductive hormones, oxidative stress, and the TSSK2 gene in a rat model of oligoasthenospermia.
Title: Effects of Qilin pills on spermatogenesis, reproductive hormones, oxidative stress, and the TSSK2 gene in a rat model of oligoasthenospermia.

Submit: New GeneRIF Correction

General gene information

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Markers

AW534143 (e-PCR)
- UniSTS:246550

UniSTS:260486 (e-PCR)
- UniSTS:260486

Dgsh (e-PCR), detects polymorphism
- UniSTS:260486

UniSTS:260495 (e-PCR)
- UniSTS:260495

Tssk2 (e-PCR), detects polymorphism
- UniSTS:260495

Stk22b (e-PCR), detects polymorphism
- UniSTS:260496

BE110023 (e-PCR)
- UniSTS:245164

AF019926 (e-PCR)
- UniSTS:158939

STK22B_9383 (e-PCR)
- UniSTS:468721

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables magnesium ion binding	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in peptidyl-serine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein autophosphorylation	ISO Inferred from Sequence Orthology more info
involved_in spermatid development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in acrosomal vesicle	ISO Inferred from Sequence Orthology more info
located_in centriole	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: testis-specific serine/threonine-protein kinase 2

Names: serine/threonine kinase 22B (spermiogenesis associated)

NP_001012019.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001012019.1 → NP_001012019.1 testis-specific serine/threonine-protein kinase 2

See identical proteins and their annotated locations for NP_001012019.1

Status: PROVISIONAL

Source sequence(s)

BC079037

UniProtKB/TrEMBL

Q6AYI0, Q6VAH7

Conserved Domains (1) summary

cd14165
Location:10 → 272

STKc_TSSK1_2-like; Catalytic domain of testis-specific serine/threonine kinase 1, TSSK2, and similar proteins