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    Rimbp2 RIMS binding protein 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 266780, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rimbp2provided by RGD
    Official Full Name
    RIMS binding protein 2provided by RGD
    Primary source
    RGD:708533
    See related
    EnsemblRapid:ENSRNOG00000022893 AllianceGenome:RGD:708533
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Rbp2; RIM-BP2
    Summary
    Predicted to enable voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels and voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential. Predicted to be a structural constituent of presynaptic active zone. Predicted to be involved in neuromuscular synaptic transmission; regulation of calcium-dependent activation of synaptic vesicle fusion; and regulation of presynaptic membrane potential. Predicted to be located in plasma membrane. Predicted to be active in calyx of Held; glutamatergic synapse; and presynaptic active zone cytoplasmic component. Orthologous to human RIMBP2 (RIMS binding protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 95.4), Brain (RPKM 54.2) and 4 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rimbp2 in Genome Data Viewer
    Location:
    12q13
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (33383646..33582259)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (27747615..27946256)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (31393229..31605567)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene syntaxin 2 Neighboring gene translation machinery-associated protein 7-like Neighboring gene uncharacterized LOC108352441 Neighboring gene piwi-like RNA-mediated gene silencing 1 Neighboring gene frizzled class receptor 10

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. RIM and RIM-BP Form Presynaptic Active-Zone-like Condensates via Phase Separation. Wu X, et al. Mol Cell, 2019 Mar 7. PMID 30661983
    2. RIM-binding protein 2 regulates release probability by fine-tuning calcium channel localization at murine hippocampal synapses. Grauel MK, et al. Proc Natl Acad Sci U S A, 2016 Oct 11. PMID 27671655, Free PMC Article
    3. Structure and evolution of RIM-BP genes: identification of a novel family member. Mittelstaedt T, et al. Gene, 2007 Nov 15. PMID 17855024
    4. The RIM/NIM family of neuronal C2 domain proteins. Interactions with Rab3 and a new class of Src homology 3 domain proteins. Wang Y, et al. J Biol Chem, 2000 Jun 30. PMID 10748113
    5. Docking motif-guided mapping of the interactome of protein phosphatase-1. Hendrickx A, et al. Chem Biol, 2009 Apr 24. PMID 19389623

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables structural constituent of presynaptic active zone ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in maintenance of presynaptic active zone structure IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neuromuscular synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of calcium-dependent activation of synaptic vesicle fusion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of presynaptic cytosolic calcium ion concentration IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of presynaptic membrane potential ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in calyx of Held ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in presynaptic active zone cytoplasmic component ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    RIMS-binding protein 2
    Names
    RIM binding protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100488.4 → NP_001093958.1  RIMS-binding protein 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000012
      UniProtKB/TrEMBL
      A0A8I5ZR68, A0A8I6A6H1
      Related
      ENSRNOP00000080836.1, ENSRNOT00000100361.2
      Conserved Domains (6) summary
      cd12012
      Location:876 → 937
      SH3_RIM-BP_2; Second Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
      cd12013
      Location:980 → 1040
      SH3_RIM-BP_3; Third Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
      cd12014
      Location:192 → 252
      SH3_RIM-BP_1; First Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
      cd00063
      Location:508 → 594
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:414 → 478
      fn3; Fibronectin type III domain
      pfam15152
      Location:642 → 683
      Kisspeptin; Kisspeptin

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      33383646..33582259
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063271095.1 → XP_063127165.1  RIMS-binding protein 2 isoform X2

      UniProtKB/TrEMBL
      A0A0G2K4J8
      Related
      ENSRNOP00000073070.3, ENSRNOT00000086078.3

    2. XM_063271096.1 → XP_063127166.1  RIMS-binding protein 2 isoform X3

      UniProtKB/TrEMBL
      A0A0G2K4J8

    3. XM_039089127.2 → XP_038945055.1  RIMS-binding protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K4J8
      Related
      ENSRNOP00000059643.3, ENSRNOT00000067867.6
      Conserved Domains (7) summary
      cd12012
      Location:1106 → 1167
      SH3_RIM-BP_2; Second Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
      cd12013
      Location:1210 → 1270
      SH3_RIM-BP_3; Third Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
      cd12014
      Location:185 → 245
      SH3_RIM-BP_1; First Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
      PHA03321
      Location:582 → 728
      PHA03321; tegument protein VP11/12; Provisional
      cd00063
      Location:501 → 587
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:407 → 474
      fn3; Fibronectin type III domain
      pfam15905
      Location:4 → 88
      HMMR_N; Hyaluronan mediated motility receptor N-terminal

    4. XM_063271099.1 → XP_063127169.1  RIMS-binding protein 2 isoform X5

      UniProtKB/TrEMBL
      A0A8I6A6H1, A6J0T2

    5. XM_063271100.1 → XP_063127170.1  RIMS-binding protein 2 isoform X6

      UniProtKB/TrEMBL
      A0A8I6A6H1

    6. XM_063271097.1 → XP_063127167.1  RIMS-binding protein 2 isoform X4

      UniProtKB/TrEMBL
      A0A8I6A6H1

    7. XM_039089126.2 → XP_038945054.1  RIMS-binding protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K4J8
      Conserved Domains (7) summary
      cd12012
      Location:1106 → 1167
      SH3_RIM-BP_2; Second Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
      cd12013
      Location:1210 → 1270
      SH3_RIM-BP_3; Third Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
      cd12014
      Location:185 → 245
      SH3_RIM-BP_1; First Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
      PHA03321
      Location:582 → 728
      PHA03321; tegument protein VP11/12; Provisional
      cd00063
      Location:501 → 587
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:407 → 474
      fn3; Fibronectin type III domain
      pfam15905
      Location:4 → 88
      HMMR_N; Hyaluronan mediated motility receptor N-terminal

    8. XM_063271102.1 → XP_063127172.1  RIMS-binding protein 2 isoform X7

      UniProtKB/TrEMBL
      A0A8I6A6H1
      Related
      ENSRNOP00000087009.1, ENSRNOT00000115151.2

    9. XM_039089128.2 → XP_038945056.1  RIMS-binding protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K4J8
      Related
      ENSRNOP00000030915.5, ENSRNOT00000033379.6
      Conserved Domains (7) summary
      cd12012
      Location:1106 → 1167
      SH3_RIM-BP_2; Second Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
      cd12013
      Location:1210 → 1270
      SH3_RIM-BP_3; Third Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
      cd12014
      Location:185 → 245
      SH3_RIM-BP_1; First Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
      PHA03321
      Location:582 → 728
      PHA03321; tegument protein VP11/12; Provisional
      cd00063
      Location:501 → 587
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:407 → 474
      fn3; Fibronectin type III domain
      pfam15905
      Location:4 → 88
      HMMR_N; Hyaluronan mediated motility receptor N-terminal

    10. XM_039089129.2 → XP_038945057.1  RIMS-binding protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K4J8
      Conserved Domains (7) summary
      cd12012
      Location:1106 → 1167
      SH3_RIM-BP_2; Second Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
      cd12013
      Location:1210 → 1270
      SH3_RIM-BP_3; Third Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
      cd12014
      Location:185 → 245
      SH3_RIM-BP_1; First Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
      PHA03321
      Location:582 → 728
      PHA03321; tegument protein VP11/12; Provisional
      cd00063
      Location:501 → 587
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:407 → 474
      fn3; Fibronectin type III domain
      pfam15905
      Location:4 → 88
      HMMR_N; Hyaluronan mediated motility receptor N-terminal

    11. XM_063271098.1 → XP_063127168.1  RIMS-binding protein 2 isoform X4

      UniProtKB/TrEMBL
      A0A8I6A6H1
      Related
      ENSRNOP00000111280.1, ENSRNOT00000158624.1

    12. XM_063271094.1 → XP_063127164.1  RIMS-binding protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K4J8
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9JIR1.2 GenPept UniProtKB/Swiss-Prot:Q9JIR1

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