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    Serpinb6b serine (or cysteine) peptidase inhibitor, clade B, member 6b [ Rattus norvegicus (Norway rat) ]

    Gene ID: 364705, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Serpinb6bprovided by RGD
    Official Full Name
    serine (or cysteine) peptidase inhibitor, clade B, member 6bprovided by RGD
    Primary source
    RGD:1310452
    See related
    EnsemblRapid:ENSRNOG00000016420 AllianceGenome:RGD:1310452
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in negative regulation of endopeptidase activity. Predicted to be located in nucleus. Predicted to be active in cytoplasm and extracellular space. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 91. Orthologous to human SERPINB6 (serpin family B member 6). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 418.0), Thymus (RPKM 136.7) and 7 other tissues See more
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    Genomic context

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    See Serpinb6b in Genome Data Viewer
    Location:
    17p12
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (31666587..31684222, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (31455092..31475460, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (32770488..32787835, complement)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene serine (or cysteine) peptidase inhibitor, clade B, member 9b Neighboring gene uncharacterized LOC108348552 Neighboring gene serpin family B member 9 Neighboring gene uncharacterized LOC102555109 Neighboring gene U2 spliceosomal RNA

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Characterization of the piRNA complex from rat testes. Lau NC, et al. Science, 2006 Jul 21. PMID 16778019
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables serine-type endopeptidase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    serine (or cysteine) peptidase inhibitor, clade B, member 6b
    Names
    serine (or cysteine) proteinase inhibitor, clade B, member 6b

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012214.1 → NP_001012214.1  serine (or cysteine) peptidase inhibitor, clade B, member 6b

      See identical proteins and their annotated locations for NP_001012214.1

      Status: PROVISIONAL

      Source sequence(s)
      BC079108
      UniProtKB/TrEMBL
      A0A9K3Y788, F7F6T5, Q68FX2
      Related
      ENSRNOP00000056665.4, ENSRNOT00000059921.6
      Conserved Domains (1) summary
      cl00137
      Location:4 → 377
      SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      31666587..31684222 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039095971.2 → XP_038951899.1  serine (or cysteine) peptidase inhibitor, clade B, member 6b isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZQA7
      Related
      ENSRNOP00000080262.1, ENSRNOT00000094444.2
      Conserved Domains (1) summary
      cl38926
      Location:1 → 388
      serpin; SERine Proteinase INhibitors (serpin) family

    2. XM_039095972.2 → XP_038951900.1  serine (or cysteine) peptidase inhibitor, clade B, member 6b isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZQA7
      Conserved Domains (1) summary
      cl38926
      Location:1 → 388
      serpin; SERine Proteinase INhibitors (serpin) family

    3. XM_039095973.2 → XP_038951901.1  serine (or cysteine) peptidase inhibitor, clade B, member 6b isoform X2

      Conserved Domains (1) summary
      cl38926
      Location:2 → 338
      serpin; SERine Proteinase INhibitors (serpin) family

    4. XM_039095974.2 → XP_038951902.1  serine (or cysteine) peptidase inhibitor, clade B, member 6b isoform X3

      Conserved Domains (1) summary
      cl38926
      Location:36 → 270
      serpin; SERine Proteinase INhibitors (serpin) family
    Nucleotide Protein Strain
    Heading Accession and Version

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