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    Rhoa ras homolog family member A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 117273, updated on 9-Dec-2024

    Summary

    Official Symbol
    Rhoaprovided by RGD
    Official Full Name
    ras homolog family member Aprovided by RGD
    Primary source
    RGD:619921
    See related
    EnsemblRapid:ENSRNOG00000050519 AllianceGenome:RGD:619921
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Arha; Arha2
    Summary
    Enables several functions, including GTPase activity; Rho GDP-dissociation inhibitor binding activity; and guanyl ribonucleotide binding activity. Involved in several processes, including negative regulation of canonical NF-kappaB signal transduction; positive regulation of protein metabolic process; and regulation of neuron projection development. Acts upstream of or within Rho protein signal transduction; negative regulation of vascular associated smooth muscle cell migration; and negative regulation of vascular associated smooth muscle cell proliferation. Located in several cellular components, including axon; dendritic spine; and neuronal cell body. Used to study membranous glomerulonephritis. Biomarker of artery disease (multiple); asthma; fetal alcohol syndrome; and obesity. Human ortholog(s) of this gene implicated in breast carcinoma. Orthologous to human RHOA (ras homolog family member A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 1085.0), Kidney (RPKM 887.2) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Rhoa in Genome Data Viewer
    Location:
    8q32
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (117870548..117904303)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (108991926..109025746)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (117082440..117116244)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene dystroglycan 1 Neighboring gene small nuclear ribonucleoprotein D2 polypeptide, pseudogene 3 Neighboring gene nicolin 1, tubulin polyglutamylase complex subunit Neighboring gene U6 snRNA-associated Sm-like protein LSm3 Neighboring gene aminomethyltransferase Neighboring gene T-cell leukemia translocation altered Neighboring gene ribosomal protein S15a, pseudogene 7 Neighboring gene glutathione peroxidase 1 Neighboring gene ubiquitin specific peptidase 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • MGC72339

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables G protein activity  
    enables GDP binding PubMed 
    enables GTP binding  
    enables GTP binding PubMed 
    enables GTP binding  
    enables GTP binding  
    enables GTP binding PubMed 
    enables GTPase activity  
    enables GTPase activity PubMed 
    enables GTPase activity  
    enables GTPase activity  
    enables GTPase activity PubMed 
    enables GTPase activity PubMed 
    enables Rho GDP-dissociation inhibitor binding PubMed 
    enables membrane scission GTPase motor activity  
    enables myosin binding  
    enables myosin binding  
    enables protein binding PubMed 
    enables protein domain specific binding PubMed 
    enables protein kinase binding  
    Items 1 - 25 of 158
    Process Evidence Code Pubs
    involved_in GTP metabolic process PubMed 
    involved_in Rho protein signal transduction  
    involved_in Rho protein signal transduction  
    acts_upstream_of_or_within Rho protein signal transduction PubMed 
    involved_in Rho protein signal transduction  
    involved_in Rho protein signal transduction  
    involved_in Roundabout signaling pathway  
    involved_in Roundabout signaling pathway  
    involved_in Roundabout signaling pathway  
    acts_upstream_of_or_within actin cytoskeleton organization  
    involved_in actin cytoskeleton organization  
    involved_in actin cytoskeleton organization  
    involved_in actin cytoskeleton organization PubMed 
    involved_in alpha-beta T cell lineage commitment  
    acts_upstream_of_or_within androgen receptor signaling pathway  
    acts_upstream_of_or_within angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure  
    involved_in aortic valve formation  
    involved_in aortic valve formation  
    involved_in apical junction assembly  
    involved_in apical junction assembly  
    involved_in apical junction assembly  
    involved_in apolipoprotein A-I-mediated signaling pathway  
    involved_in apolipoprotein A-I-mediated signaling pathway  
    involved_in beta selection  
    involved_in bone trabecula morphogenesis  
    acts_upstream_of_or_within cell adhesion  
    acts_upstream_of_or_within cell differentiation  
    involved_in cell junction assembly  
    involved_in cell junction assembly  
    involved_in cell migration  
    involved_in cell migration  
    involved_in cell migration  
    acts_upstream_of_or_within cell morphogenesis  
    acts_upstream_of_or_within cell-matrix adhesion  
    involved_in cellular response to chemokine  
    involved_in cellular response to chemokine  
    involved_in cellular response to chemokine  
    involved_in cellular response to cytokine stimulus  
    involved_in cellular response to lipopolysaccharide  
    involved_in cellular response to lipopolysaccharide  
    involved_in cellular response to progesterone stimulus PubMed 
    acts_upstream_of_or_within cerebral cortex cell migration  
    involved_in cleavage furrow formation  
    involved_in cleavage furrow formation  
    involved_in cytoplasmic microtubule organization  
    involved_in cytoplasmic microtubule organization  
    acts_upstream_of_or_within cytoskeleton organization  
    involved_in embryonic cleavage  
    involved_in endothelial cell migration  
    acts_upstream_of_or_within endothelial cell migration  
    involved_in endothelial tube lumen extension  
    acts_upstream_of_or_within endothelial tube lumen extension  
    involved_in establishment of epithelial cell apical/basal polarity  
    involved_in establishment of epithelial cell apical/basal polarity  
    involved_in establishment of epithelial cell apical/basal polarity  
    involved_in establishment or maintenance of actin cytoskeleton polarity  
    acts_upstream_of_or_within forebrain radial glial cell differentiation  
    acts_upstream_of_or_within kidney development  
    involved_in meiotic spindle organization  
    involved_in microtubule depolymerization PubMed 
    involved_in mitotic cleavage furrow formation  
    involved_in mitotic cleavage furrow formation  
    involved_in mitotic cleavage furrow formation  
    involved_in mitotic spindle assembly  
    involved_in mitotic spindle assembly  
    acts_upstream_of motor neuron apoptotic process  
    involved_in negative chemotaxis  
    involved_in negative chemotaxis  
    involved_in negative regulation of canonical NF-kappaB signal transduction PubMed 
    involved_in negative regulation of cell migration involved in sprouting angiogenesis  
    acts_upstream_of_or_within negative regulation of cell migration involved in sprouting angiogenesis  
    involved_in negative regulation of cell size  
    involved_in negative regulation of cell size  
    involved_in negative regulation of cell-substrate adhesion  
    acts_upstream_of_or_within negative regulation of intracellular steroid hormone receptor signaling pathway  
    acts_upstream_of_or_within negative regulation of motor neuron apoptotic process  
    involved_in negative regulation of neuron differentiation PubMed 
    involved_in negative regulation of neuron projection development PubMed 
    involved_in negative regulation of oxidative phosphorylation  
    involved_in negative regulation of reactive oxygen species biosynthetic process  
    involved_in negative regulation of synapse assembly PubMed 
    acts_upstream_of_or_within negative regulation of vascular associated smooth muscle cell migration PubMed 
    acts_upstream_of_or_within negative regulation of vascular associated smooth muscle cell proliferation PubMed 
    acts_upstream_of_or_within neuron migration  
    involved_in neuron projection morphogenesis PubMed 
    involved_in odontogenesis  
    involved_in ossification involved in bone maturation  
    involved_in polar body extrusion after meiotic divisions  
    involved_in positive regulation of T cell migration  
    involved_in positive regulation of T cell migration  
    involved_in positive regulation of T cell migration  
    involved_in positive regulation of actin filament polymerization PubMed 
    involved_in positive regulation of alpha-beta T cell differentiation  
    involved_in positive regulation of canonical NF-kappaB signal transduction  
    involved_in positive regulation of canonical NF-kappaB signal transduction  
    involved_in positive regulation of canonical NF-kappaB signal transduction  
    involved_in positive regulation of cell adhesion PubMed 
    involved_in positive regulation of cell growth PubMed 
    involved_in positive regulation of cell growth PubMed 
    involved_in positive regulation of cell migration PubMed 
    involved_in positive regulation of cytokinesis  
    involved_in positive regulation of cytokinesis  
    involved_in positive regulation of cytokinesis  
    involved_in positive regulation of leukocyte adhesion to vascular endothelial cell  
    involved_in positive regulation of leukocyte adhesion to vascular endothelial cell  
    involved_in positive regulation of lipase activity  
    involved_in positive regulation of neuron apoptotic process PubMed 
    involved_in positive regulation of neuron differentiation  
    acts_upstream_of_or_within positive regulation of neuron differentiation  
    acts_upstream_of_or_within positive regulation of podosome assembly  
    involved_in positive regulation of protein serine/threonine kinase activity  
    involved_in positive regulation of protein serine/threonine kinase activity  
    involved_in positive regulation of smooth muscle contraction PubMed 
    involved_in positive regulation of stress fiber assembly  
    acts_upstream_of_or_within positive regulation of stress fiber assembly  
    involved_in positive regulation of stress fiber assembly  
    involved_in positive regulation of translation PubMed 
    acts_upstream_of_or_within positive regulation of vascular associated smooth muscle contraction  
    involved_in positive regulation of vasoconstriction PubMed 
    involved_in regulation of actin cytoskeleton organization  
    involved_in regulation of actin cytoskeleton organization  
    involved_in regulation of actin polymerization or depolymerization PubMed 
    involved_in regulation of calcium ion transport PubMed 
    involved_in regulation of cell migration  
    involved_in regulation of cell migration  
    involved_in regulation of dendrite development PubMed 
    involved_in regulation of microtubule cytoskeleton organization  
    involved_in regulation of modification of postsynaptic actin cytoskeleton  
    involved_in regulation of modification of postsynaptic actin cytoskeleton  
    involved_in regulation of modification of postsynaptic structure  
    acts_upstream_of_or_within regulation of neural precursor cell proliferation  
    acts_upstream_of_or_within regulation of neuron projection development  
    involved_in regulation of osteoblast proliferation  
    acts_upstream_of_or_within regulation of systemic arterial blood pressure by endothelin  
    acts_upstream_of_or_within regulation of transcription by RNA polymerase II  
    involved_in response to amino acid PubMed 
    involved_in response to ethanol PubMed 
    involved_in response to glucocorticoid PubMed 
    involved_in response to glucose PubMed 
    involved_in response to hypoxia PubMed 
    involved_in response to mechanical stimulus PubMed 
    involved_in response to xenobiotic stimulus PubMed 
    involved_in response to xenobiotic stimulus PubMed 
    involved_in semaphorin-plexin signaling pathway  
    involved_in skeletal muscle satellite cell migration  
    acts_upstream_of_or_within skeletal muscle tissue development  
    involved_in small GTPase-mediated signal transduction  
    involved_in spindle localization  
    involved_in stress fiber assembly  
    involved_in stress fiber assembly  
    acts_upstream_of_or_within stress fiber assembly  
    involved_in stress fiber assembly  
    involved_in stress fiber assembly  
    involved_in stress-activated protein kinase signaling cascade PubMed 
    involved_in substantia nigra development PubMed 
    involved_in substrate adhesion-dependent cell spreading  
    involved_in substrate adhesion-dependent cell spreading  
    involved_in wound healing, spreading of cells  
    Items 1 - 25 of 158
    Items 1 - 20 of 40
    Component Evidence Code Pubs
    located_in apical junction complex  
    located_in apical junction complex  
    located_in apical junction complex  
    located_in axon PubMed 
    located_in cell cortex  
    located_in cell cortex  
    located_in cell cortex  
    located_in cell periphery  
    is_active_in cleavage furrow  
    located_in cleavage furrow  
    located_in cleavage furrow  
    located_in cleavage furrow  
    located_in cytoplasmic side of plasma membrane  
    located_in cytoplasmic side of plasma membrane  
    located_in cytoplasmic side of plasma membrane  
    located_in cytoskeleton  
    is_active_in cytosol  
    located_in cytosol PubMed 
    located_in cytosol  
    located_in cytosol  
    located_in dendrite PubMed 
    is_active_in dendritic spine  
    located_in dendritic spine PubMed 
    located_in endosome  
    located_in endosome  
    located_in glutamatergic synapse  
    is_active_in glutamatergic synapse  
    located_in lamellipodium  
    located_in lamellipodium  
    located_in meiotic spindle  
    located_in membrane PubMed 
    located_in midbody  
    located_in neuronal cell body PubMed 
    located_in nucleus  
    is_active_in plasma membrane  
    located_in plasma membrane  
    located_in postsynapse  
    is_active_in postsynapse  
    located_in ruffle membrane  
    located_in vesicle  
    Items 1 - 20 of 40

    General protein information

    Preferred Names
    transforming protein RhoA
    Names
    plysia ras-related homolog A2
    ras homolog gene family, member A
    NP_476473.1
    XP_006243761.1
    XP_006243762.1
    XP_006243763.1
    XP_038936642.1
    XP_063120856.1
    XP_063120857.1
    XP_063120858.1
    XP_063120859.1
    XP_063120860.1
    XP_063120861.1
    XP_063120862.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_057132.3NP_476473.1  transforming protein RhoA

      See identical proteins and their annotated locations for NP_476473.1

      Status: PROVISIONAL

      Source sequence(s)
      AY026068
      UniProtKB/Swiss-Prot
      P61589
      UniProtKB/TrEMBL
      A0A8I6AFP1, A6I347
      Conserved Domains (1) summary
      cd01870
      Location:5179
      RhoA_like; Ras homology family A (RhoA)-like includes RhoA, RhoB and RhoC

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      117870548..117904303
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063264790.1XP_063120860.1  transforming protein RhoA isoform X1

      UniProtKB/Swiss-Prot
      P61589
      UniProtKB/TrEMBL
      A0A8I6AFP1, A6I347
    2. XM_063264789.1XP_063120859.1  transforming protein RhoA isoform X1

      UniProtKB/Swiss-Prot
      P61589
      UniProtKB/TrEMBL
      A0A8I6AFP1, A6I347
    3. XM_006243700.3XP_006243762.1  transforming protein RhoA isoform X1

      See identical proteins and their annotated locations for XP_006243762.1

      UniProtKB/Swiss-Prot
      P61589
      UniProtKB/TrEMBL
      A0A8I6AFP1, A6I347
      Conserved Domains (1) summary
      cd01870
      Location:5179
      RhoA_like; Ras homology family A (RhoA)-like includes RhoA, RhoB and RhoC
    4. XM_063264786.1XP_063120856.1  transforming protein RhoA isoform X1

      UniProtKB/Swiss-Prot
      P61589
      UniProtKB/TrEMBL
      A0A8I6AFP1, A6I347
      Related
      ENSRNOP00000091658.1, ENSRNOT00000094929.2
    5. XM_063264788.1XP_063120858.1  transforming protein RhoA isoform X1

      UniProtKB/Swiss-Prot
      P61589
      UniProtKB/TrEMBL
      A0A8I6AFP1, A6I347
    6. XM_063264787.1XP_063120857.1  transforming protein RhoA isoform X1

      UniProtKB/Swiss-Prot
      P61589
      UniProtKB/TrEMBL
      A0A8I6AFP1, A6I347
    7. XM_006243699.3XP_006243761.1  transforming protein RhoA isoform X1

      See identical proteins and their annotated locations for XP_006243761.1

      UniProtKB/Swiss-Prot
      P61589
      UniProtKB/TrEMBL
      A0A8I6AFP1, A6I347
      Conserved Domains (1) summary
      cd01870
      Location:5179
      RhoA_like; Ras homology family A (RhoA)-like includes RhoA, RhoB and RhoC
    8. XM_063264792.1XP_063120862.1  transforming protein RhoA isoform X1

      UniProtKB/Swiss-Prot
      P61589
      UniProtKB/TrEMBL
      A0A8I6AFP1, A6I347
    9. XM_039080714.2XP_038936642.1  transforming protein RhoA isoform X1

      UniProtKB/Swiss-Prot
      P61589
      UniProtKB/TrEMBL
      A0A8I6AFP1, A6I347
      Conserved Domains (1) summary
      cd01870
      Location:5179
      RhoA_like; Ras homology family A (RhoA)-like includes RhoA, RhoB and RhoC
    10. XM_063264791.1XP_063120861.1  transforming protein RhoA isoform X1

      UniProtKB/Swiss-Prot
      P61589
      UniProtKB/TrEMBL
      A0A8I6AFP1, A6I347
    11. XM_006243701.2XP_006243763.1  transforming protein RhoA isoform X1

      See identical proteins and their annotated locations for XP_006243763.1

      UniProtKB/Swiss-Prot
      P61589
      UniProtKB/TrEMBL
      A0A8I6AFP1, A6I347
      Conserved Domains (1) summary
      cd01870
      Location:5179
      RhoA_like; Ras homology family A (RhoA)-like includes RhoA, RhoB and RhoC
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