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    Ube2n ubiquitin-conjugating enzyme E2N [ Rattus norvegicus (Norway rat) ]

    Gene ID: 116725, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ube2nprovided by RGD
    Official Full Name
    ubiquitin-conjugating enzyme E2Nprovided by RGD
    Primary source
    RGD:621096
    See related
    EnsemblRapid:ENSRNOG00000073414 AllianceGenome:RGD:621096
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables ubiquitin-protein transferase activity. Involved in regulation protein catabolic process at postsynapse. Is active in glutamatergic synapse and postsynapse. Orthologous to human UBE2N (ubiquitin conjugating enzyme E2 N). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 481.8), Brain (RPKM 455.2) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Ube2n in Genome Data Viewer
    Location:
    7q13
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (32041190..32071252)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (30154330..30184373)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (36610147..36640190)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein L42 Neighboring gene uncharacterized LOC102556774 Neighboring gene nudix hydrolase 4 Neighboring gene uncharacterized LOC102546610

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • MGC93937

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding  
    enables ubiquitin binding  
    enables ubiquitin conjugating enzyme activity  
    contributes_to ubiquitin conjugating enzyme activity  
    enables ubiquitin conjugating enzyme activity  
    enables ubiquitin conjugating enzyme activity  
    enables ubiquitin protein ligase binding  
    enables ubiquitin-protein transferase activator activity  
    enables ubiquitin-protein transferase activity PubMed 
    enables ubiquitin-protein transferase activity  
    enables ubiquitin-protein transferase activity  
    Items 1 - 25 of 26
    Process Evidence Code Pubs
    acts_upstream_of DNA double-strand break processing  
    involved_in T cell receptor signaling pathway  
    involved_in antiviral innate immune response  
    involved_in biological_process  
    acts_upstream_of double-strand break repair via homologous recombination  
    involved_in negative regulation of TORC1 signaling  
    involved_in positive regulation of DNA repair  
    involved_in positive regulation of NF-kappaB transcription factor activity  
    involved_in positive regulation of canonical NF-kappaB signal transduction  
    involved_in positive regulation of double-strand break repair  
    involved_in positive regulation of intracellular signal transduction  
    involved_in positive regulation of protein K63-linked ubiquitination  
    involved_in postreplication repair  
    acts_upstream_of postreplication repair  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process  
    involved_in protein K63-linked ubiquitination  
    involved_in protein K63-linked ubiquitination  
    involved_in protein K63-linked ubiquitination  
    involved_in protein monoubiquitination  
    involved_in protein polyubiquitination  
    involved_in protein ubiquitination PubMed 
    involved_in regulation protein catabolic process at postsynapse PubMed 
    involved_in regulation protein catabolic process at postsynapse PubMed 
    involved_in regulation protein catabolic process at postsynapse PubMed 
    acts_upstream_of_or_within ubiquitin-dependent protein catabolic process  
    involved_in ubiquitin-dependent protein catabolic process PubMed 
    Items 1 - 25 of 26
    Component Evidence Code Pubs
    part_of UBC13-MMS2 complex  
    part_of UBC13-MMS2 complex  
    located_in cytoplasm  
    located_in cytosol  
    is_active_in glutamatergic synapse PubMed 
    is_active_in glutamatergic synapse PubMed 
    is_active_in nucleus  
    located_in nucleus  
    is_active_in postsynapse PubMed 
    part_of protein-containing complex  
    part_of ubiquitin conjugating enzyme complex  
    part_of ubiquitin ligase complex  
    part_of ubiquitin ligase complex  

    General protein information

    Preferred Names
    ubiquitin-conjugating enzyme E2 N
    Names
    E2 ubiquitin-conjugating enzyme N
    bendless protein
    bendless-like ubiquitin-conjugating enzyme
    ubiquitin carrier protein N
    ubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast)
    ubiquitin-conjugating enzyme E2N (homologous to yeast UBC13)
    ubiquitin-protein ligase N
    NP_446380.1
    XP_063118946.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053928.2NP_446380.1  ubiquitin-conjugating enzyme E2 N

      See identical proteins and their annotated locations for NP_446380.1

      Status: PROVISIONAL

      Source sequence(s)
      BC090072
      UniProtKB/Swiss-Prot
      Q9EQX9
      UniProtKB/TrEMBL
      A6IG42
      Related
      ENSRNOP00000108459.1, ENSRNOT00000138953.1
      Conserved Domains (1) summary
      cl00154
      Location:4151
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      32041190..32071252
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063262876.1XP_063118946.1  ubiquitin-conjugating enzyme E2 N isoform X1

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