Slc15a3 solute carrier family 15 member 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc15a3provided by RGD
Official Full Name: solute carrier family 15 member 3provided by RGD
Primary source: RGD:628663
See related: EnsemblRapid:ENSRNOG00000021644 AllianceGenome:RGD:628663
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Pht2
Summary: Predicted to enable dipeptide transmembrane transporter activity and peptidoglycan transmembrane transporter activity. Predicted to be involved in dipeptide import across plasma membrane; peptidoglycan transport; and positive regulation of nucleotide-binding activity oligomerization domain containing 2 signaling pathway. Located in lysosomal membrane. Orthologous to human SLC15A3 (solute carrier family 15 member 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 117.6), Thymus (RPKM 74.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q43

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (216906836..216932046)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (207492365..207507158)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (226896387..226912644)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These findings represent the first evidence that peptide transport via SLC15a1, 2, 3, and 4 occurs in thyroid follicular cells.
Title: Functional expression of SLC15 peptide transporters in rat thyroid follicular cells.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables dipeptide transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables dipeptide transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables dipeptide transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables peptidoglycan transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables peptidoglycan transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables proton-dependent oligopeptide secondary active transmembrane transporter activity	TAS Traceable Author Statement more info	PubMed
enables symporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in dipeptide import across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in dipeptide import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in dipeptide import across plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in peptidoglycan transport	ISO Inferred from Sequence Orthology more info
involved_in peptidoglycan transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein catabolic process	NAS Non-traceable Author Statement more info	PubMed
involved_in protein transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in endosome membrane	ISO Inferred from Sequence Orthology more info
located_in endosome membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
is_active_in lysosomal membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in lysosomal membrane	IDA Inferred from Direct Assay more info	PubMed
located_in lysosomal membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: solute carrier family 15 member 3

Names: peptide transporter 3; peptide/histidine transporter 2; peptide/histidine transporter PHT2; solute carrier family 15 (oligopeptide transporter), member 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_139341.1 → NP_647557.1 solute carrier family 15 member 3

See identical proteins and their annotated locations for NP_647557.1

Status: PROVISIONAL

Source sequence(s)

AB026665

UniProtKB/Swiss-Prot

Q924V4

UniProtKB/TrEMBL

A6I061

Related

ENSRNOP00000034275.2, ENSRNOT00000029443.5

Conserved Domains (2) summary

COG3104
Location:41 → 572

PTR2; Dipeptide/tripeptide permease [Amino acid transport and metabolism]

cl21472
Location:177 → 521

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

216906836..216932046

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063280966.1 → XP_063137036.1 solute carrier family 15 member 3 isoform X1

UniProtKB/Swiss-Prot

Q924V4

UniProtKB/TrEMBL

A6I061
XM_063280969.1 → XP_063137039.1 solute carrier family 15 member 3 isoform X2