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    Zfp382 zinc finger protein 382 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 246264, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zfp382provided by RGD
    Official Full Name
    zinc finger protein 382provided by RGD
    Primary source
    RGD:708385
    See related
    EnsemblRapid:ENSRNOG00000020777 AllianceGenome:RGD:708385
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ks1; Znf382
    Summary
    Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Orthologous to human ZNF382 (zinc finger protein 382). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 49.9), Lung (RPKM 24.7) and 9 other tissues See more
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    Genomic context

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    See Zfp382 in Genome Data Viewer
    Location:
    1q21
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (94504344..94528316)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (85377614..85400832)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (88582641..88603219)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA5 Neighboring gene zinc finger protein 566 Neighboring gene zinc finger protein 260 Neighboring gene zinc finger protein 146 Neighboring gene prothymosin alpha, pseudogene 5 Neighboring gene cytochrome c oxidase subunit 7A1 Neighboring gene ribosomal protein S24, pseudogene 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. KRAB-independent suppression of neoplastic cell growth by the novel zinc finger transcription factor KS1. Gebelein B, et al. J Clin Invest, 1998 Dec 1. PMID 9835615, Free PMC Article
    2. Sequence-specific transcriptional repression by KS1, a multiple-zinc-finger-Krüppel-associated box protein. Gebelein B, et al. Mol Cell Biol, 2001 Feb. PMID 11154279, Free PMC Article
    3. Large-scale characterization of DNA methylation changes in human gastric carcinomas with and without metastasis. Liu Z, et al. Clin Cancer Res, 2014 Sep 1. PMID 25009298, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC156588

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cell growth NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 382
    Names
    KRAB/zinc finger suppressor protein 1 (KS1)
    multiple zinc finger and krueppel-associated box protein KS1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001393683.1 → NP_001380612.1  zinc finger protein 382 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      Conserved Domains (3) summary
      smart00349
      Location:12 → 72
      KRAB; krueppel associated box
      COG5048
      Location:293 → 532
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:437 → 457
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. NM_001393684.1 → NP_001380613.1  zinc finger protein 382 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/Swiss-Prot
      A0JPL0, Q62977
      Conserved Domains (3) summary
      smart00349
      Location:12 → 72
      KRAB; krueppel associated box
      COG5048
      Location:293 → 532
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:437 → 457
      ZF_C2H2; C2H2 Zn finger [structural motif]

    3. NM_144749.2 → NP_653350.1  zinc finger protein 382 isoform 2

      See identical proteins and their annotated locations for NP_653350.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A0G2JSS4
      Related
      ENSRNOP00000028187.5, ENSRNOT00000028187.8
      Conserved Domains (6) summary
      smart00349
      Location:12 → 72
      KRAB; krueppel associated box
      COG5048
      Location:293 → 532
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:437 → 457
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:493 → 513
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:12 → 51
      KRAB; KRAB box
      pfam13465
      Location:505 → 530
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      94504344..94528316
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063280994.1 → XP_063137064.1  zinc finger protein 382 isoform X6

    2. XM_063281003.1 → XP_063137073.1  zinc finger protein 382 isoform X8

      UniProtKB/TrEMBL
      A0A8L2UPH4

    3. XM_063280982.1 → XP_063137052.1  zinc finger protein 382 isoform X3

    4. XM_063280998.1 → XP_063137068.1  zinc finger protein 382 isoform X7

    5. XM_063280978.1 → XP_063137048.1  zinc finger protein 382 isoform X2

      Related
      ENSRNOP00000102670.1, ENSRNOT00000153151.1

    6. XM_063280991.1 → XP_063137061.1  zinc finger protein 382 isoform X5

    7. XM_063280977.1 → XP_063137047.1  zinc finger protein 382 isoform X1

    8. XM_063280989.1 → XP_063137059.1  zinc finger protein 382 isoform X4

    9. XM_063280996.1 → XP_063137066.1  zinc finger protein 382 isoform X6

      Related
      ENSRNOP00000069192.3, ENSRNOT00000087931.3

    RNA

    1. XR_010063130.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0JPL0.1 GenPept UniProtKB/Swiss-Prot:A0JPL0

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