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    Htra1 HtrA serine peptidase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 65164, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Htra1provided by RGD
    Official Full Name
    HtrA serine peptidase 1provided by RGD
    Primary source
    RGD:69235
    See related
    EnsemblRapid:ENSRNOG00000020533 AllianceGenome:RGD:69235
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Prss11
    Summary
    Predicted to enable identical protein binding activity; molecular function activator activity; and serine-type endopeptidase activity. Involved in dentinogenesis; negative regulation of defense response to virus; and positive regulation of epithelial cell proliferation. Located in collagen-containing extracellular matrix. Human ortholog(s) of this gene implicated in CADASIL (multiple); gastrointestinal system cancer (multiple); hypertension; lung adenocarcinoma; and macular degeneration (multiple). Orthologous to human HTRA1 (HtrA serine peptidase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 413.0), Heart (RPKM 246.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Htra1 in Genome Data Viewer
    Location:
    1q41
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (194928069..194977619)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (185497815..185547380)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (201499067..201548508)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene BTB domain containing 16 Neighboring gene pleckstrin homology domain containing A1 Neighboring gene uncharacterized LOC134485181 Neighboring gene deleted in malignant brain tumors 1 Neighboring gene similar to human chromosome 10 open reading frame 120

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. HtrA1, a potential predictor of response to cisplatin-based combination chemotherapy in gastric cancer. Catalano V, et al. Histopathology, 2011 Apr. PMID 21447133
    2. Identifying subtypes of patients with neovascular age-related macular degeneration by genotypic and cardiovascular risk characteristics. Feehan M, et al. BMC Med Genet, 2011 Jun 17. PMID 21682878, Free PMC Article
    3. Quantitative determination of high-temperature requirement protein A1 and its possible associated molecules during induced reparative dentin formation. Li X, et al. J Endod, 2012 Jun. PMID 22595117
    4. Association of genetic polymorphisms and age-related macular degeneration in Chinese population. Tian J, et al. Invest Ophthalmol Vis Sci, 2012 Jun 28. PMID 22618592
    5. [Interaction of susceptibility genes in patients with exudative age-related macular degeneration]. Liang X, et al. Zhonghua Yan Ke Za Zhi, 2012 Mar. PMID 22800422

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Porphyromonas gingivalis-mediated disruption in spiral artery remodeling is associated with altered uterine NK cell populations and dysregulated IL-18 and Htra1.
      Title: Porphyromonas gingivalis-mediated disruption in spiral artery remodeling is associated with altered uterine NK cell populations and dysregulated IL-18 and Htra1.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC93339

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables growth factor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables molecular function activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type peptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables serine-type peptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in chorionic trophoblast cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within chorionic trophoblast cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in dentinogenesis IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in negative regulation of BMP signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of BMP signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of defense response to virus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of transforming growth factor beta receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of transforming growth factor beta receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in placenta development IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within placenta development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of epithelial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in programmed cell death IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteolysis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in collagen-containing extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in collagen-containing extracellular matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    serine protease HTRA1
    Names
    high-temperature requirement A serine peptidase 1
    protease serine 11
    protease, serine, 11 (Igf binding)
    serine protease 11
    NP_113909.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031721.1 → NP_113909.1  serine protease HTRA1 precursor

      See identical proteins and their annotated locations for NP_113909.1

      Status: PROVISIONAL

      Source sequence(s)
      AF179370
      UniProtKB/Swiss-Prot
      Q9QZK5
      UniProtKB/TrEMBL
      A0A8L2QHG9
      Related
      ENSRNOP00000027860.3, ENSRNOT00000027860.6
      Conserved Domains (5) summary
      smart00121
      Location:37 → 111
      IB; Insulin growth factor-binding protein homologues
      smart00280
      Location:115 → 155
      KAZAL; Kazal type serine protease inhibitors
      COG0265
      Location:154 → 480
      DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
      cd00987
      Location:382 → 473
      PDZ_serine_protease; PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind ...
      pfam13365
      Location:204 → 342
      Trypsin_2; Trypsin-like peptidase domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      194928069..194977619
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9QZK5.1 GenPept UniProtKB/Swiss-Prot:Q9QZK5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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