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    Comt catechol-O-methyltransferase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24267, updated on 9-Dec-2024

    Summary

    Official Symbol
    Comtprovided by RGD
    Official Full Name
    catechol-O-methyltransferaseprovided by RGD
    Primary source
    RGD:2379
    See related
    EnsemblRapid:ENSRNOG00000001889 AllianceGenome:RGD:2379
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables catechol O-methyltransferase activity. Involved in several processes, including learning or memory; negative regulation of dopamine metabolic process; and positive regulation of homocysteine metabolic process. Located in several cellular components, including cell body; dendritic spine; and postsynaptic membrane. Is active in glutamatergic synapse and postsynapse. Used to study Parkinsonism and hypertension. Biomarker of hypertension. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease of skin and connective tissue (multiple); cognitive disorder (multiple); drug dependence (multiple); reproductive organ cancer (multiple); and withdrawal disorder (multiple). Orthologous to human COMT (catechol-O-methyltransferase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 2550.1), Kidney (RPKM 1227.4) and 5 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Comt in Genome Data Viewer
    Location:
    11q23
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (96072371..96091956)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (82568052..82587642)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (86715981..86735630)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene T-box transcription factor 1 Neighboring gene G protein subunit beta 1 like Neighboring gene uncharacterized LOC120095703 Neighboring gene thioredoxin reductase 2 Neighboring gene ARVCF, delta catenin family member Neighboring gene small Cajal body-specific RNA 14 like 2 Neighboring gene transport and golgi organization 2 homolog Neighboring gene microRNA 185

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables catechol O-methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables catechol O-methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables catechol O-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables catechol O-methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in S-adenosylhomocysteine metabolic process TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in S-adenosylmethionine metabolic process TAS
    Traceable Author Statement
    more info
    PubMed 
    acts_upstream_of_or_within artery development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within behavioral fear response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in catecholamine catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in catecholamine catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in catecholamine catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in catecholamine catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within catecholamine metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cellular response to cocaine ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cellular response to phosphate starvation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cerebellar cortex morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cholesterol efflux ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cognition ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within detection of temperature stimulus involved in sensory perception of pain ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in developmental process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in developmental process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within dopamine catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in dopamine metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in dopamine metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within dopamine metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within dopamine secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in estrogen metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within exploration behavior ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within fear response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in female pregnancy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within glomerulus development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within glycogen metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within habituation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within kidney development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in learning IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within learning ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within learning or memory ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within mastication ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within memory ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in methylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in methylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within multicellular organism growth ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within multicellular organismal response to stress ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of dopamine metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of smooth muscle cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within norepinephrine metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within norepinephrine secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of homocysteine metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of lactation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within prostaglandin metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within protein methylation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of blood pressure ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within renal albumin absorption ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within renal filtration ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within renal sodium excretion ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within renin secretion into blood stream ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within response to amphetamine ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within response to angiotensin ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within response to corticosterone ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within response to cytokine ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within response to dopamine ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to estrogen IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    acts_upstream_of_or_within response to food ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within response to hypoxia ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to lipopolysaccharide IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to organic cyclic compound IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    acts_upstream_of_or_within response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to pain IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within response to salt ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within response to stress ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within response to temperature stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within response to toxic substance ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within response to wounding ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to xenobiotic stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    acts_upstream_of_or_within response to xenobiotic stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in short-term memory IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within startle response ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within synaptic transmission, dopaminergic ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within visual learning ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in axon IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in axon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell body ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in dendritic spine IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in glial cell projection ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in intracellular membrane-bounded organelle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in postsynapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in postsynaptic membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in vesicle ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    catechol O-methyltransferase
    Names
    catecholamine-O-methyltransferase
    NP_036663.1
    XP_006248665.1
    XP_063126344.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012531.2NP_036663.1  catechol O-methyltransferase

      See identical proteins and their annotated locations for NP_036663.1

      Status: VALIDATED

      Source sequence(s)
      BC081850, CK478774
      UniProtKB/Swiss-Prot
      P22734
      UniProtKB/TrEMBL
      A0A8I6AHB1, F2W8B0, F2W8B1
      Related
      ENSRNOP00000092582.1, ENSRNOT00000104392.2
      Conserved Domains (1) summary
      COG4122
      Location:44238
      YrrM; Predicted O-methyltransferase YrrM [General function prediction only]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      96072371..96091956
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063270274.1XP_063126344.1  catechol O-methyltransferase isoform X2

      UniProtKB/Swiss-Prot
      P22734
      UniProtKB/TrEMBL
      A0A8I6AHB1, F2W8B0, F2W8B1
      Related
      ENSRNOP00000043148.5, ENSRNOT00000050269.7
    2. XM_006248603.5XP_006248665.1  catechol O-methyltransferase isoform X1

      UniProtKB/TrEMBL
      A0A8I6A1I0, A0A8I6AHB1
      Related
      ENSRNOP00000086073.1, ENSRNOT00000119057.2
      Conserved Domains (1) summary
      cl17173
      Location:61228
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...