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    Vcpip1 valosin containing protein interacting protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 286761, updated on 9-Dec-2024

    Summary

    Official Symbol
    Vcpip1provided by RGD
    Official Full Name
    valosin containing protein interacting protein 1provided by RGD
    Primary source
    RGD:708520
    See related
    EnsemblRapid:ENSRNOG00000006980 AllianceGenome:RGD:708520
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Vcip135
    Summary
    Enables cysteine-type deubiquitinase activity. Involved in Golgi reassembly; endoplasmic reticulum membrane fusion; and protein ubiquitination. Predicted to be located in cytoplasm and nucleus. Predicted to be active in synapse. Orthologous to human VCPIP1 (valosin containing protein interacting protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 228.0), Thymus (RPKM 214.8) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Vcpip1 in Genome Data Viewer
    Location:
    5q11
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (14317083..14343724)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (9534247..9560889)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (9231180..9257821)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene eukaryotic translation elongation factor 1 gamma, pseudogene 4 Neighboring gene interferon-induced transmembrane protein 2-like Neighboring gene MYB proto-oncogene like 1 Neighboring gene vexin

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cysteine-type deubiquitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables cysteine-type deubiquitinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables cysteine-type deubiquitinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in DNA damage response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in DNA damage response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in Golgi organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in Golgi reassembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in Golgi reassembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in endoplasmic reticulum membrane fusion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in endoplasmic reticulum membrane fusion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein K11-linked deubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein K11-linked deubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein K48-linked deubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein K48-linked deubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein deubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein deubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein-DNA covalent cross-linking repair IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein-DNA covalent cross-linking repair ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein-DNA covalent cross-linking repair ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of protein localization to chromatin ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of protein localization to chromatin ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in Golgi stack IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in synapse ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    deubiquitinating protein VCPIP1
    Names
    VCP(p97)/p47-interacting protein
    VCP/p47 complex-interacting 135-kDa protein
    deubiquitinating protein VCIP135
    valosin-containing protein (p97)/p47 complex-interacting protein 135
    valosin-containing protein p97/p47 complex-interacting protein 1
    valosin-containing protein p97/p47 complex-interacting protein p135
    NP_789827.3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_176857.3NP_789827.3  deubiquitinating protein VCPIP1

      See identical proteins and their annotated locations for NP_789827.3

      Status: PROVISIONAL

      Source sequence(s)
      AB045378
      UniProtKB/Swiss-Prot
      Q7TNK5, Q8CF97
      UniProtKB/TrEMBL
      A6JFG0
      Related
      ENSRNOP00000009136.3, ENSRNOT00000009136.6
      Conserved Domains (1) summary
      cl19932
      Location:214354
      OTU; OTU-like cysteine protease

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      14317083..14343724
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)