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    Daam1 dishevelled associated activator of morphogenesis 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 314212, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Daam1provided by RGD
    Official Full Name
    dishevelled associated activator of morphogenesis 1provided by RGD
    Primary source
    RGD:1305119
    See related
    EnsemblRapid:ENSRNOG00000004345 AllianceGenome:RGD:1305119
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable identical protein binding activity. Involved in presynaptic actin cytoskeleton organization. Is active in glutamatergic synapse and presynapse. Orthologous to human DAAM1 (dishevelled associated activator of morphogenesis 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 129.9), Lung (RPKM 117.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Daam1 in Genome Data Viewer
    Location:
    6q24
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (96125521..96286049)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (90389544..90550114)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (94606675..94739026)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120093260 Neighboring gene uncharacterized LOC108351250 Neighboring gene large ribosomal subunit protein eL15-like Neighboring gene uncharacterized LOC120103547 Neighboring gene G protein-coupled receptor 135

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. D-Aspartate Upregulates DAAM1 Protein Levels in the Rat Testis and Induces Its Localization in Spermatogonia Nucleus. Venditti M, et al. Biomolecules, 2020 Apr 28. PMID 32353957, Free PMC Article
    2. Involvement of testicular DAAM1 expression in zinc protection against cadmium-induced male rat reproductive toxicity. Chemek M, et al. J Cell Physiol, 2018 Jan. PMID 28332181
    3. First Evidence of DAAM1 Localization During the Post-Natal Development of Rat Testis and in Mammalian Sperm. Pariante P, et al. J Cell Physiol, 2016 Oct. PMID 26831620
    4. Piccolo Directs Activity Dependent F-Actin Assembly from Presynaptic Active Zones via Daam1. Wagh D, et al. PLoS One, 2015. PMID 25897839, Free PMC Article
    5. Localization of the Diaphanous-related formin Daam1 to neuronal dendrites. Salomon SN, et al. Neurosci Lett, 2008 Dec 5. PMID 18832009

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. D-Aspartate Upregulates DAAM1 Protein Levels in the Rat Testis and Induces Its Localization in Spermatogonia Nucleus.
      Title: D-Aspartate Upregulates DAAM1 Protein Levels in the Rat Testis and Induces Its Localization in Spermatogonia Nucleus.
    2. Zinc chloride could prevent cadmium chloride-induced testicular toxicity and sperm quality alteration in adult male rat after gestational and lactational exposure, probably via the restoration of the testicular DAAM1 expression inhibited by Cd.
      Title: Involvement of testicular DAAM1 expression in zinc protection against cadmium-induced male rat reproductive toxicity.
    3. a role for DAAM1 in cytoskeletal organization during Mammalian testis morphogenesis and gamete progression
      Title: First Evidence of DAAM1 Localization During the Post-Natal Development of Rat Testis and in Mammalian Sperm.
    4. Similar to Piccolo and Profilin, Daam1 loss of function impairs presynaptic-F-actin assembly in neurons.
      Title: Piccolo Directs Activity Dependent F-Actin Assembly from Presynaptic Active Zones via Daam1.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in presynaptic actin cytoskeleton organization EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in presynaptic actin cytoskeleton organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in presynaptic actin cytoskeleton organization IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in presynaptic actin cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in ciliary basal body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in motile cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in presynapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in stress fiber IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in stress fiber ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    disheveled-associated activator of morphogenesis 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108030.1 → NP_001101500.1  disheveled-associated activator of morphogenesis 1 isoform 1

      See identical proteins and their annotated locations for NP_001101500.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473947
      UniProtKB/TrEMBL
      A0A8I5Y0A6, A6HC27, D4ABM3
      Related
      ENSRNOP00000005846.4, ENSRNOT00000005846.6
      Conserved Domains (4) summary
      pfam02181
      Location:512 → 873
      FH2; Formin Homology 2 Domain
      pfam06367
      Location:235 → 439
      Drf_FH3; Diaphanous FH3 Domain
      pfam06371
      Location:45 → 232
      Drf_GBD; Diaphanous GTPase-binding Domain
      pfam10211
      Location:450 → 507
      Ax_dynein_light; Axonemal dynein light chain

    2. NM_001433960.1 → NP_001420889.1  disheveled-associated activator of morphogenesis 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A8I5Y0A6, A0A8I6GM04

    3. NM_001433961.1 → NP_001420890.1  disheveled-associated activator of morphogenesis 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A8I5Y0A6, A0A8I6GM04

    4. NM_001433962.1 → NP_001420891.1  disheveled-associated activator of morphogenesis 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A8I5Y0A6, A0A8I6GM04

    5. NM_001433963.1 → NP_001420892.1  disheveled-associated activator of morphogenesis 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A8I5Y0A6

    6. NM_001433964.1 → NP_001420893.1  disheveled-associated activator of morphogenesis 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A8I5Y0A6

    7. NM_001433965.1 → NP_001420894.1  disheveled-associated activator of morphogenesis 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A8I5Y0A6

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      96125521..96286049
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063261925.1 → XP_063117995.1  disheveled-associated activator of morphogenesis 1 isoform X2

      Related
      ENSRNOP00000100888.1, ENSRNOT00000162986.1

    2. XM_039112262.2 → XP_038968190.1  disheveled-associated activator of morphogenesis 1 isoform X1

      Conserved Domains (4) summary
      PRK12704
      Location:444 → 513
      PRK12704; phosphodiesterase; Provisional
      pfam06367
      Location:235 → 439
      Drf_FH3; Diaphanous FH3 Domain
      pfam02181
      Location:600 → 983
      FH2; Formin Homology 2 Domain
      pfam06371
      Location:45 → 232
      Drf_GBD; Diaphanous GTPase-binding Domain

    3. XM_063261924.1 → XP_063117994.1  disheveled-associated activator of morphogenesis 1 isoform X2

      Related
      ENSRNOP00000107911.1, ENSRNOT00000137984.1

    4. XM_039112260.2 → XP_038968188.1  disheveled-associated activator of morphogenesis 1 isoform X1

      Related
      ENSRNOP00000096283.1, ENSRNOT00000110744.2
      Conserved Domains (4) summary
      PRK12704
      Location:444 → 513
      PRK12704; phosphodiesterase; Provisional
      pfam06367
      Location:235 → 439
      Drf_FH3; Diaphanous FH3 Domain
      pfam02181
      Location:600 → 983
      FH2; Formin Homology 2 Domain
      pfam06371
      Location:45 → 232
      Drf_GBD; Diaphanous GTPase-binding Domain

    5. XM_039112265.2 → XP_038968193.1  disheveled-associated activator of morphogenesis 1 isoform X2

      Conserved Domains (4) summary
      PRK12704
      Location:444 → 513
      PRK12704; phosphodiesterase; Provisional
      pfam06367
      Location:235 → 439
      Drf_FH3; Diaphanous FH3 Domain
      pfam02181
      Location:600 → 973
      FH2; Formin Homology 2 Domain
      pfam06371
      Location:45 → 232
      Drf_GBD; Diaphanous GTPase-binding Domain

    6. XM_039112261.2 → XP_038968189.1  disheveled-associated activator of morphogenesis 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I5Y0A6, A0A8I6GM04
      Conserved Domains (4) summary
      PRK12704
      Location:444 → 513
      PRK12704; phosphodiesterase; Provisional
      pfam06367
      Location:235 → 439
      Drf_FH3; Diaphanous FH3 Domain
      pfam02181
      Location:600 → 983
      FH2; Formin Homology 2 Domain
      pfam06371
      Location:45 → 232
      Drf_GBD; Diaphanous GTPase-binding Domain

    7. XM_039112263.2 → XP_038968191.1  disheveled-associated activator of morphogenesis 1 isoform X1

      Conserved Domains (4) summary
      PRK12704
      Location:444 → 513
      PRK12704; phosphodiesterase; Provisional
      pfam06367
      Location:235 → 439
      Drf_FH3; Diaphanous FH3 Domain
      pfam02181
      Location:600 → 983
      FH2; Formin Homology 2 Domain
      pfam06371
      Location:45 → 232
      Drf_GBD; Diaphanous GTPase-binding Domain

    8. XM_039112264.2 → XP_038968192.1  disheveled-associated activator of morphogenesis 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I5Y0A6, A0A8I6GM04
      Conserved Domains (4) summary
      PRK12704
      Location:444 → 513
      PRK12704; phosphodiesterase; Provisional
      pfam06367
      Location:235 → 439
      Drf_FH3; Diaphanous FH3 Domain
      pfam02181
      Location:600 → 983
      FH2; Formin Homology 2 Domain
      pfam06371
      Location:45 → 232
      Drf_GBD; Diaphanous GTPase-binding Domain

    9. XM_039112266.2 → XP_038968194.1  disheveled-associated activator of morphogenesis 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I5Y0A6, A0A8I6GM04
      Conserved Domains (4) summary
      PRK12704
      Location:444 → 513
      PRK12704; phosphodiesterase; Provisional
      pfam06367
      Location:235 → 439
      Drf_FH3; Diaphanous FH3 Domain
      pfam02181
      Location:600 → 983
      FH2; Formin Homology 2 Domain
      pfam06371
      Location:45 → 232
      Drf_GBD; Diaphanous GTPase-binding Domain
    Nucleotide Protein Strain
    Heading Accession and Version

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