Akap1 A-kinase anchoring protein 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Akap1provided by RGD
Official Full Name: A-kinase anchoring protein 1provided by RGD
Primary source: RGD:620826
See related: EnsemblRapid:ENSRNOG00000002373 AllianceGenome:RGD:620826
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Akap84
Summary: Enables several functions, including enzyme binding activity; protein kinase A regulatory subunit binding activity; and tubulin binding activity. Involved in several processes, including cellular response to cAMP; negative regulation of cell growth involved in cardiac muscle cell development; and negative regulation of protein import into nucleus. Located in lipid droplet; mitochondrial crista; and postsynaptic membrane. Is active in neuromuscular junction and postsynaptic specialization, intracellular component. Biomarker of brain ischemia. Orthologous to human AKAP1 (A-kinase anchoring protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Heart (RPKM 364.2), Testes (RPKM 254.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q26

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (74118232..74151366, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (73621021..73654123, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (76151013..76183987, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

AKAP1 alleviates VSMC phenotypic modulation and neointima formation by inhibiting Drp1-dependent mitochondrial fission.
Title: AKAP1 alleviates VSMC phenotypic modulation and neointima formation by inhibiting Drp1-dependent mitochondrial fission.
AKAP1 mediates high glucose-induced mitochondrial fission through the phosphorylation of Drp1 in podocytes.
Title: AKAP1 mediates high glucose-induced mitochondrial fission through the phosphorylation of Drp1 in podocytes.
the scaffold protein A kinase anchoring protein 1 brings the cAMP-dependent protein kinase A to the outer mitochondrial membrane to protect neurons from injury
Title: Mechanism of neuroprotective mitochondrial remodeling by PKA/AKAP1.
AKAP121 regulates the response to stress in cardiomyocytes, and therefore AKAP121 downregulation might represent an important event contributing to the development of cardiac dysfunction.
Title: AKAP121 downregulation impairs protective cAMP signals, promotes mitochondrial dysfunction, and increases oxidative stress.
We purified a 120 kDa protein which can bind both the regulatory subunit of PKA as well as the catalytic subunit of protein phosphatase 1 (PP1)
Title: Identification and characterization of D-AKAP1 as a major adipocyte PKA and PP1 binding protein.
These results are the first to identify AKAP121 as a negative regulator of cardiomyocyte hypertrophy.
Title: The A-kinase anchor protein AKAP121 is a negative regulator of cardiomyocyte hypertrophy.
90% or more of mitochondrial C-PKA, R-PKA and AKAP121 is localized in the inner mitochondrial compartment, when prepared both from isolated mitochondria or cardiomyocyte cultures
Title: Occurrence of A-kinase anchor protein and associated cAMP-dependent protein kinase in the inner compartment of mammalian mitochondria.
Akap1 signaling complex mediates Adra1a-induced cardiomyocyte hypertrophy.
Title: The A-kinase anchoring protein (AKAP)-Lbc-signaling complex mediates alpha1 adrenergic receptor-induced cardiomyocyte hypertrophy.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables beta-tubulin binding	IDA Inferred from Direct Assay more info	PubMed
enables microtubule binding	IDA Inferred from Direct Assay more info	PubMed
enables molecular adaptor activity	IDA Inferred from Direct Assay more info	PubMed
enables protein kinase A regulatory subunit binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase A regulatory subunit binding	IDA Inferred from Direct Assay more info	PubMed
enables protein kinase A regulatory subunit binding	IEA Inferred from Electronic Annotation more info
enables protein kinase A regulatory subunit binding	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	IDA Inferred from Direct Assay more info	PubMed
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein phosphatase binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in antiviral innate immune response	IEA Inferred from Electronic Annotation more info
involved_in antiviral innate immune response	ISO Inferred from Sequence Orthology more info
involved_in antiviral innate immune response	ISS Inferred from Sequence or Structural Similarity more info
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to cAMP	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to peptide hormone stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in negative regulation of cell growth involved in cardiac muscle cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of dephosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of protein import into nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of meiotic cell cycle process involved in oocyte maturation	ISO Inferred from Sequence Orthology more info
involved_in protein localization	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein kinase A signaling	IC Inferred by Curator more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in lipid droplet	IDA Inferred from Direct Assay more info	PubMed
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial crista	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial outer membrane	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
is_active_in neuromuscular junction	IDA Inferred from Direct Assay more info	PubMed
located_in neuromuscular junction	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic specialization, intracellular component	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: A-kinase anchor protein 1, mitochondrial

Names: A kinase (PRKA) anchor protein 1; A-kinase anchor protein 121 kDa; AKAP 121; D-AKAP-1; PRKA1; S-AKAP84; a kinase anchor protein 1, mitochondrial; dual specificity A-kinase-anchoring protein 1; protein kinase A-anchoring protein 1; spermatid A-kinase anchor protein 84

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053665.1 → NP_446117.1 A-kinase anchor protein 1, mitochondrial

See identical proteins and their annotated locations for NP_446117.1

Status: PROVISIONAL

Source sequence(s)

AF068202

UniProtKB/Swiss-Prot

O88884, O88980

Conserved Domains (4) summary

smart00333
Location:707 → 765

TUDOR; Tudor domain

cd00105
Location:562 → 622

KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...

pfam00567
Location:655 → 777

TUDOR; Tudor domain

pfam04814
Location:394 → 510

HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N terminus

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

74118232..74151366 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006247068.3 → XP_006247130.1 A-kinase anchor protein 1, mitochondrial isoform X1

See identical proteins and their annotated locations for XP_006247130.1

UniProtKB/TrEMBL

A6HHY7, F1LMK0

Conserved Domains (4) summary

smart00333
Location:707 → 765

TUDOR; Tudor domain

cd00105
Location:562 → 622

KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...

pfam00567
Location:655 → 777

TUDOR; Tudor domain

pfam04814
Location:394 → 510

HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N terminus
XM_063268270.1 → XP_063124340.1 A-kinase anchor protein 1, mitochondrial isoform X4
XM_006247067.5 → XP_006247129.1 A-kinase anchor protein 1, mitochondrial isoform X1

See identical proteins and their annotated locations for XP_006247129.1

UniProtKB/TrEMBL

A6HHY7, F1LMK0

Conserved Domains (4) summary

smart00333
Location:707 → 765

TUDOR; Tudor domain

cd00105
Location:562 → 622

KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...

pfam00567
Location:655 → 777

TUDOR; Tudor domain

pfam04814
Location:394 → 510

HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N terminus
XM_063268268.1 → XP_063124338.1 A-kinase anchor protein 1, mitochondrial isoform X4
XM_008767930.3 → XP_008766152.1 A-kinase anchor protein 1, mitochondrial isoform X1

See identical proteins and their annotated locations for XP_008766152.1

UniProtKB/TrEMBL

A6HHY7, F1LMK0

Related

ENSRNOP00000052543.5, ENSRNOT00000055683.7

Conserved Domains (4) summary

smart00333
Location:707 → 765

TUDOR; Tudor domain

cd00105
Location:562 → 622

KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...

pfam00567
Location:655 → 777

TUDOR; Tudor domain

pfam04814
Location:394 → 510

HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N terminus
XM_063268271.1 → XP_063124341.1 A-kinase anchor protein 1, mitochondrial isoform X5
XM_063268272.1 → XP_063124342.1 A-kinase anchor protein 1, mitochondrial isoform X5
XM_039085023.2 → XP_038940951.1 A-kinase anchor protein 1, mitochondrial isoform X2

Conserved Domains (2) summary

PHA03307
Location:336 → 498

PHA03307; transcriptional regulator ICP4; Provisional

cd22395
Location:560 → 609

KH-I_AKAP1; type I K homology (KH) RNA-binding domain found in mitochondrial A-kinase anchor protein 1 (AKAP1) and similar proteins
XM_039085025.2 → XP_038940953.1 A-kinase anchor protein 1, mitochondrial isoform X3

UniProtKB/TrEMBL

A6HHY9, D4A9M6

Related

ENSRNOP00000003251.7, ENSRNOT00000003251.9

Conserved Domains (1) summary

NF033201
Location:279 → 490

Vip_LPXTG_Lm; cell invasion LPXTG protein Vip