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    Acox2 acyl-CoA oxidase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 252898, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Acox2provided by RGD
    Official Full Name
    acyl-CoA oxidase 2provided by RGD
    Primary source
    RGD:628684
    See related
    EnsemblRapid:ENSRNOG00000007378 AllianceGenome:RGD:628684
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    THCCox
    Summary
    Enables 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase activity; fatty acid binding activity; and flavin adenine dinucleotide binding activity. Involved in fatty acid beta-oxidation. Located in peroxisome. Human ortholog(s) of this gene implicated in congenital bile acid synthesis defect 6. Orthologous to human ACOX2 (acyl-CoA oxidase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 982.6) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Acox2 in Genome Data Viewer
    Location:
    15p14
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (19090820..19122392)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (16660584..16692160)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (18449304..18481472)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120096928 Neighboring gene family with sequence similarity 107, member A Neighboring gene uncharacterized LOC120096930 Neighboring gene potassium channel tetramerization domain containing 6 Neighboring gene heat shock protein family E (Hsp10) member 1, pseudogene 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Three-dimensional structure of rat-liver acyl-CoA oxidase in complex with a fatty acid: insights into substrate-recognition and reactivity toward molecular oxygen. Tokuoka K, et al. J Biochem, 2006 Apr. PMID 16672280
    2. Molecular cloning and further characterization of rat peroxisomal trihydroxycoprostanoyl-CoA oxidase. Baumgart E, et al. Biochem J, 1996 Nov 15. PMID 8947475, Free PMC Article
    3. ACOX2 deficiency: An inborn error of bile acid synthesis identified in an adolescent with persistent hypertransaminasemia. Monte MJ, et al. J Hepatol, 2017 Mar. PMID 27884763
    4. Peroxisomal beta-oxidation of 2-methyl-branched acyl-CoA esters: stereospecific recognition of the 2S-methyl compounds by trihydroxycoprostanoyl-CoA oxidase and pristanoyl-CoA oxidase. Van Veldhoven PP, et al. FEBS Lett, 1996 Jun 10. PMID 8654595
    5. Separate peroxisomal oxidases for fatty acyl-CoAs and trihydroxycoprostanoyl-CoA in human liver. Casteels M, et al. J Lipid Res, 1990 Oct. PMID 2079609

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The overall dimeric structure and the folding pattern of each subunit are essentially superimposable on those of uncomplexed acyl-CoA oxidase-II structure.
      Title: Three-dimensional structure of rat-liver acyl-CoA oxidase in complex with a fatty acid: insights into substrate-recognition and reactivity toward molecular oxygen.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables FAD binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acyl-CoA oxidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables fatty acid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables fatty acid binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables fatty acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables flavin adenine dinucleotide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables flavin adenine dinucleotide binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables palmitoyl-CoA oxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in bile acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in bile acid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in bile acid biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in fatty acid beta-oxidation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in fatty acid beta-oxidation using acyl-CoA oxidase IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fatty acid beta-oxidation using acyl-CoA oxidase IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fatty acid beta-oxidation using acyl-CoA oxidase ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in fatty acid metabolic process IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in very long-chain fatty acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in peroxisome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in peroxisome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in peroxisome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in peroxisome ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    peroxisomal acyl-coenzyme A oxidase 2
    Names
    3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoyl-CoA 24-hydroxylase
    3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoyl-CoA oxidase
    THCA-CoA oxidase
    acyl-CoA oxidase 2, branched chain
    acyl-Coenzyme A oxidase 2, branched chain
    trihydroxycoprostanoyl-CoA oxidase
    NP_665713.2
    XP_006251805.2
    XP_006251806.1
    XP_038948932.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145770.4 → NP_665713.2  peroxisomal acyl-coenzyme A oxidase 2

      See identical proteins and their annotated locations for NP_665713.2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/Swiss-Prot
      P97562
      UniProtKB/TrEMBL
      F1LNW3
      Related
      ENSRNOP00000010260.3, ENSRNOT00000010260.6
      Conserved Domains (1) summary
      cd01150
      Location:20 → 655
      AXO; Peroxisomal acyl-CoA oxidase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      19090820..19122392
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006251744.4 → XP_006251806.1  peroxisomal acyl-coenzyme A oxidase 2 isoform X1

      See identical proteins and their annotated locations for XP_006251806.1

      UniProtKB/Swiss-Prot
      P97562
      UniProtKB/TrEMBL
      F1LNW3
      Conserved Domains (1) summary
      cd01150
      Location:20 → 655
      AXO; Peroxisomal acyl-CoA oxidase

    2. XM_006251743.4 → XP_006251805.2  peroxisomal acyl-coenzyme A oxidase 2 isoform X1

      UniProtKB/Swiss-Prot
      P97562
      UniProtKB/TrEMBL
      F1LNW3
      Conserved Domains (1) summary
      cd01150
      Location:20 → 655
      AXO; Peroxisomal acyl-CoA oxidase

    3. XM_039093004.2 → XP_038948932.1  peroxisomal acyl-coenzyme A oxidase 2 isoform X1

      UniProtKB/Swiss-Prot
      P97562
      UniProtKB/TrEMBL
      F1LNW3
      Conserved Domains (1) summary
      cd01150
      Location:20 → 655
      AXO; Peroxisomal acyl-CoA oxidase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P97562.1 GenPept UniProtKB/Swiss-Prot:P97562

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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