Rbm10 RNA binding motif protein 10 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rbm10provided by RGD
Official Full Name: RNA binding motif protein 10provided by RGD
Primary source: RGD:631366
See related: EnsemblRapid:ENSRNOG00000008472 AllianceGenome:RGD:631366
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables single-stranded RNA binding activity. Involved in several processes, including cardiac muscle cell myoblast differentiation; negative regulation of RNA metabolic process; and negative regulation of cell growth involved in cardiac muscle cell development. Predicted to be located in nuclear speck. Predicted to be part of protein-containing complex. Predicted to be active in nucleolus. Biomarker of congestive heart failure. Human ortholog(s) of this gene implicated in TARP syndrome; colorectal cancer; lung adenocarcinoma; and lung cancer. Orthologous to human RBM10 (RNA binding motif protein 10). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 168.9), Spleen (RPKM 125.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: Xq11

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (4093914..4126060, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (1540399..1572571, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (1754869..1786973, complement)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

This work establishes myoblast differentiation as a relevant model in which to conduct functional studies regarding Rbm5 and Rbm10.
Title: Differential downregulation of Rbm5 and Rbm10 during skeletal and cardiac differentiation.
Overexpression of S1-1 sense resulted in VSMC in significant stabilization of AT1 receptor mRNA.
Title: The heterogenous nuclear riboprotein S1-1 regulates AT1 receptor gene expression via transcriptional and posttranscriptional mechanisms.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

UniSTS:479219 (e-PCR)
- UniSTS:479219

Rbm10 (e-PCR), detects polymorphism
- UniSTS:479219

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables miRNA binding	IEA Inferred from Electronic Annotation more info
enables miRNA binding	ISO Inferred from Sequence Orthology more info
enables miRNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables single-stranded RNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in 3'-UTR-mediated mRNA stabilization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within 3'-UTR-mediated mRNA stabilization	ISO Inferred from Sequence Orthology more info
involved_in cardiac muscle cell myoblast differentiation	IEP Inferred from Expression Pattern more info	PubMed
involved_in mRNA splicing, via spliceosome	IBA Inferred from Biological aspect of Ancestor more info
involved_in mRNA stabilization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell growth involved in cardiac muscle cell development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of mRNA splicing, via spliceosome	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of mRNA splicing, via spliceosome	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of ribosomal large subunit export from nucleus	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of vascular associated smooth muscle cell proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of vascular associated smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of execution phase of apoptosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of vascular associated smooth muscle cell apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of vascular associated smooth muscle cell apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of vascular associated smooth muscle cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in vascular associated smooth muscle cell apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of vascular associated smooth muscle cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in vascular associated smooth muscle cell proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of vascular associated smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in nuclear speck	IEA Inferred from Electronic Annotation more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
is_active_in nucleolus	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: RNA-binding protein 10

Names: RNA-binding protein S1-1; S1-1 protein from liver

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001414396.1 → NP_001401325.1 RNA-binding protein 10 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000021

UniProtKB/TrEMBL

A0A8I6A0D6, A0A8I6ACC8

Related

ENSRNOP00000011317.6, ENSRNOT00000011317.8
NM_152861.5 → NP_690600.1 RNA-binding protein 10 isoform 1

See identical proteins and their annotated locations for NP_690600.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000021

UniProtKB/Swiss-Prot

P70501

UniProtKB/TrEMBL

A0A8I6A0D6, A6JZT5

Conserved Domains (7) summary

smart00547
Location:138 → 162

ZnF_RBZ; Zinc finger domain

COG0724
Location:211 → 321

RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

cd12754
Location:221 → 307

RRM2_RBM10; RNA recognition motif 2 in vertebrate RNA-binding protein 10 (RBM10)

sd00025
Location:140 → 159

zf-RanBP2; RanBP2-type Zn finger [structural motif]

pfam01585
Location:780 → 824

G-patch; G-patch domain

cd16167
Location:486 → 549

OCRE_RBM10; OCRE domain found in RNA-binding protein 10 (RBM10) and similar proteins

cl17169
Location:67 → 134

RRM_SF; RNA recognition motif (RRM) superfamily

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086039.1 Reference GRCr8

Range

4093914..4126060 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063280282.1 → XP_063136352.1 RNA-binding protein 10 isoform X2

UniProtKB/TrEMBL

A0A8I6A0D6

Related

ENSRNOP00000084552.2, ENSRNOT00000096592.2
XM_063280281.1 → XP_063136351.1 RNA-binding protein 10 isoform X1

UniProtKB/TrEMBL

A0A8I6A0D6, A6JZT6

Related

ENSRNOP00000072756.2, ENSRNOT00000077453.3
XM_039100026.2 → XP_038955954.1 RNA-binding protein 10 isoform X4

Conserved Domains (5) summary

smart00547
Location:12 → 36

ZnF_RBZ; Zinc finger domain

sd00029
Location:14 → 33

zf-RanBP2; RanBP2-type Zn finger [structural motif]

cd16167
Location:360 → 423

OCRE_RBM10; OCRE domain found in RNA-binding protein 10 (RBM10) and similar proteins

pfam01585
Location:654 → 698

G-patch; G-patch domain

cd12754
Location:95 → 181

RRM2_RBM10; RNA recognition motif 2 (RRM2) found in vertebrate RNA-binding protein 10 (RBM10)
XM_039100025.2 → XP_038955953.1 RNA-binding protein 10 isoform X3

UniProtKB/TrEMBL

A0A8I6A0D6

Conserved Domains (6) summary

smart00547
Location:54 → 78

ZnF_RBZ; Zinc finger domain

sd00029
Location:56 → 75

zf-RanBP2; RanBP2-type Zn finger [structural motif]

cd16167
Location:402 → 465

OCRE_RBM10; OCRE domain found in RNA-binding protein 10 (RBM10) and similar proteins

pfam01585
Location:696 → 740

G-patch; G-patch domain

cd12754
Location:137 → 223

RRM2_RBM10; RNA recognition motif 2 (RRM2) found in vertebrate RNA-binding protein 10 (RBM10)

cl17169
Location:1 → 50

RRM_SF; RNA recognition motif (RRM) superfamily