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    Clec2g C-type lectin domain family 2, member G [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362447, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Clec2gprovided by RGD
    Official Full Name
    C-type lectin domain family 2, member Gprovided by RGD
    Primary source
    RGD:1563148
    See related
    EnsemblRapid:ENSRNOG00000059538 AllianceGenome:RGD:1563148
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Clrb; Clr-b; Clr11; CLEC2D11; RGD1563148
    Summary
    Predicted to enable natural killer cell lectin-like receptor binding activity. Predicted to be located in plasma membrane. Predicted to be active in external side of plasma membrane. Orthologous to human CLEC2D (C-type lectin domain family 2 member D). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 4381.3), Spleen (RPKM 2908.6) and 8 other tissues See more
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    Genomic context

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    See Clec2g in Genome Data Viewer
    Location:
    4q42
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (164303865..164313737)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (162617827..162627699)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (162934195..162942891)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene U7 small nuclear RNA Neighboring gene Rhox homeobox family member 5, pseudogene 1 Neighboring gene uncharacterized LOC100909928 Neighboring gene Cd69 molecule

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Cytomegalovirus evasion of innate immunity by subversion of the NKR-P1B:Clr-b missing-self axis. Voigt S, et al. Immunity, 2007 May. PMID 17462921
    2. Two major groups of rat NKR-P1 receptors can be distinguished based on chromosomal localization, phylogenetic analysis and Clr ligand binding. Kveberg L, et al. Eur J Immunol, 2009 Feb. PMID 19130483
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. existence of lectin-like genes in several poxviruses suggests that this may represent a common theme for viral evasion of innate immunity
      Title: Cytomegalovirus evasion of innate immunity by subversion of the NKR-P1B:Clr-b missing-self axis.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables natural killer cell lectin-like receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    C-type lectin domain family 2 member D11
    Names
    C-type lectin domain family 2, member d11
    C-type lectin-related protein 11
    C-type lectin-related protein B
    Ocil/Clrb-like protein
    lectin-like transmembrane protein
    osteoclast inhibitory lectin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001048075.2 → NP_001041540.1  C-type lectin domain family 2 member D11

      See identical proteins and their annotated locations for NP_001041540.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/Swiss-Prot
      Q0H8B7, Q0H8B8, Q0H8B9
      UniProtKB/TrEMBL
      B8PS70
      Related
      ENSRNOP00000069630.3, ENSRNOT00000083188.3
      Conserved Domains (2) summary
      cd03593
      Location:80 → 192
      CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)
      PHA02867
      Location:41 → 196
      PHA02867; C-type lectin protein; Provisional

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      164303865..164313737
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039107902.1 → XP_038963830.1  C-type lectin domain family 2 member D11 isoform X1

      UniProtKB/TrEMBL
      A6IM36
      Conserved Domains (1) summary
      PHA02642
      Location:14 → 160
      PHA02642; C-type lectin-like protein; Provisional
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q0H8B9.1 GenPept UniProtKB/Swiss-Prot:Q0H8B9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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