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    Otud3 OTU deubiquitinase 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 500572, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Otud3provided by RGD
    Official Full Name
    OTU deubiquitinase 3provided by RGD
    Primary source
    RGD:1560468
    See related
    EnsemblRapid:ENSRNOG00000017037 AllianceGenome:RGD:1560468
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1560468
    Summary
    Predicted to enable cysteine-type deubiquitinase activity. Predicted to be involved in cellular response to nutrient levels; protein deubiquitination; and protein stabilization. Predicted to act upstream of or within negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction and protein deubiquitination. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Orthologous to human OTUD3 (OTU deubiquitinase 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 65.3), Muscle (RPKM 49.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Otud3 in Genome Data Viewer
    Location:
    5q36
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (156419099..156445341, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (151135826..151162207, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (157346286..157368450, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene phospholipase A2, group V Neighboring gene phospholipase A2 group IIA Neighboring gene phospholipase A2, group IIE Neighboring gene uncharacterized LOC134487023 Neighboring gene ring finger protein 186

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Deubiquitylase OTUD3 regulates PTEN stability and suppresses tumorigenesis. Yuan L, et al. Nat Cell Biol, 2015 Sep. PMID 26280536
    2. OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis. Mevissen TE, et al. Cell, 2013 Jul 3. PMID 23827681, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cysteine-type deubiquitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-type deubiquitinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to nutrient levels ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein K11-linked deubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein K11-linked deubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein K27-linked deubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein K48-linked deubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein K48-linked deubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein K6-linked deubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein K6-linked deubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein deubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein stabilization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein stabilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein stabilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    OTU domain-containing protein 3
    Names
    OTU domain containing 3
    NP_001178912.1
    XP_038966556.1
    XP_038966558.1
    XP_038966559.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191983.1 → NP_001178912.1  OTU domain-containing protein 3

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      D4A7M3
      Related
      ENSRNOP00000023143.5, ENSRNOT00000023143.9
      Conserved Domains (1) summary
      cl19932
      Location:70 → 156
      OTU; OTU-like cysteine protease

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      156419099..156445341 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039110631.1 → XP_038966559.1  OTU domain-containing protein 3 isoform X3

      Conserved Domains (1) summary
      PRK10811
      Location:89 → 163
      rne; ribonuclease E; Reviewed

    2. XM_039110630.1 → XP_038966558.1  OTU domain-containing protein 3 isoform X2

      Conserved Domains (1) summary
      PRK10811
      Location:130 → 204
      rne; ribonuclease E; Reviewed

    3. XM_039110628.2 → XP_038966556.1  OTU domain-containing protein 3 isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version

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