Plin5 perilipin 5 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Plin5provided by RGD
Official Full Name: perilipin 5provided by RGD
Primary source: RGD:1589602
See related: EnsemblRapid:ENSRNOG00000047860 AllianceGenome:RGD:1589602
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Oxpat
Summary: Enables lipase binding activity. Involved in positive regulation of fatty acid beta-oxidation; positive regulation of lipase activity; and positive regulation of sequestering of triglyceride. Located in lipid droplet and mitochondrion. Orthologous to human PLIN5 (perilipin 5). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Heart (RPKM 166.8), Muscle (RPKM 78.1) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 9q11

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (1026910..1033352, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (939745..946188, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (10956013..10961782)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Perilipin 5 regulates hepatic stellate cell activation and high-fat diet-induced non-alcoholic fatty liver disease.
Title: Perilipin 5 regulates hepatic stellate cell activation and high-fat diet-induced non-alcoholic fatty liver disease.
Perilipin 5 Reduces Oxidative Damage Associated With Lipotoxicity by Activating the PI3K/ERK-Mediated Nrf2-ARE Signaling Pathway in INS-1 Pancreatic beta-Cells.
Title: Perilipin 5 Reduces Oxidative Damage Associated With Lipotoxicity by Activating the PI3K/ERK-Mediated Nrf2-ARE Signaling Pathway in INS-1 Pancreatic β-Cells.
These results suggest that lipotoxic protection afforded by natural PLIN5 upregulation in muscle involves molecular changes in lipid composition within LDs.
Title: Perilipin 5 mediated lipid droplet remodelling revealed by coherent Raman imaging.
Exposure to a maternal high fat diet resulted in higher skeletal muscle lipid and PLIN5 content in plantaris of offspring through to young adulthood.
Title: A maternal high fat diet has long-lasting effects on skeletal muscle lipid and PLIN protein content in rat offspring at young adulthood.
role of perilipin 5 in mitochondria
Title: Perilipin 5, a lipid droplet-associated protein, provides physical and metabolic linkage to mitochondria.
This study demonstrates, for the first time, the presence of OXPAT and TIP47 transcripts in rat hepatocytes, as well as their up-regulation with lipid accumulation.
Title: PAT protein mRNA expression in primary rat hepatocytes: Effects of exposure to fatty acids.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables lipase binding	IPI Inferred from Physical Interaction more info	PubMed
enables lipase binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in lipid droplet organization	ISO Inferred from Sequence Orthology more info
involved_in lipid droplet organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in lipid storage	IBA Inferred from Biological aspect of Ancestor more info
involved_in lipid storage	ISO Inferred from Sequence Orthology more info
involved_in mitochondrion localization	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of fatty acid beta-oxidation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of fatty acid beta-oxidation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of lipase activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of lipase activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of lipid catabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of peroxisome proliferator activated receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of peroxisome proliferator activated receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of reactive oxygen species metabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of reactive oxygen species metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of triglyceride catabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of triglyceride catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of fatty acid beta-oxidation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of fatty acid beta-oxidation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of lipase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of lipid storage	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of sequestering of triglyceride	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of sequestering of triglyceride	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of sequestering of triglyceride	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of triglyceride biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of triglyceride biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
is_active_in lipid droplet	IBA Inferred from Biological aspect of Ancestor more info
located_in lipid droplet	IDA Inferred from Direct Assay more info	PubMed
located_in lipid droplet	ISO Inferred from Sequence Orthology more info
located_in lipid droplet	ISS Inferred from Sequence or Structural Similarity more info
NOT located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: perilipin-5

Names: lipid storage droplet protein 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001134637.1 → NP_001128109.1 perilipin-5

See identical proteins and their annotated locations for NP_001128109.1

Status: PROVISIONAL

Source sequence(s)

CH474092

UniProtKB/Swiss-Prot

M0R7Z9

Related

ENSRNOP00000065588.1, ENSRNOT00000073930.3

Conserved Domains (1) summary

pfam03036
Location:31 → 409

Perilipin; Perilipin family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086027.1 Reference GRCr8

Range

1026910..1033352 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039084131.2 → XP_038940059.1 perilipin-5 isoform X3

Related

ENSRNOP00000111121.1, ENSRNOT00000125167.1

Conserved Domains (1) summary

pfam03036
Location:31 → 371

Perilipin; Perilipin family
XM_039084130.2 → XP_038940058.1 perilipin-5 isoform X2

Conserved Domains (1) summary

pfam03036
Location:31 → 391

Perilipin; Perilipin family
XM_039084129.2 → XP_038940057.1 perilipin-5 isoform X1

UniProtKB/Swiss-Prot

M0R7Z9

Conserved Domains (1) summary

pfam03036
Location:31 → 409

Perilipin; Perilipin family