Epn1 Epsin 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Epn1provided by RGD
Official Full Name: Epsin 1provided by RGD
Primary source: RGD:619772
See related: EnsemblRapid:ENSRNOG00000015753 AllianceGenome:RGD:619772
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables clathrin adaptor activity and transmembrane transporter binding activity. Involved in several processes, including clathrin coat assembly; membrane fission; and positive regulation of clathrin coat assembly. Located in cytosol; postsynaptic membrane; and presynaptic membrane. Is active in Schaffer collateral - CA1 synapse and postsynapse. Biomarker of middle cerebral artery infarction. Orthologous to human EPN1 (epsin 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 330.3), Heart (RPKM 299.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q12

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (77771335..77789411, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (68742491..68760570, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (72294153..72310217, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Epsin but not AP-2 supports reconstitution of endocytic clathrin-coated vesicles.
Title: Epsin but not AP-2 supports reconstitution of endocytic clathrin-coated vesicles.
This study finds that epsin preferentially partitions to and assembles clathrin on highly curved membrane surfaces.
Title: Spatial Control of Epsin-induced Clathrin Assembly by Membrane Curvature.
The mechanism of bundling of cytoskeletal actin filaments by two representative bundling proteins, fascin and espin, was examined.
Title: Cooperativity and frustration in protein-mediated parallel actin bundles.
epsin1 is located across both sides of the synapse, whereas HIP1 displays a preference for the postsynaptic compartment; results suggest a dual role for epsin1 and huntingtin-interacting protein 1 in the synapse
Title: Partially overlapping distribution of epsin1 and HIP1 at the synapse: analysis by immunoelectron microscopy.
An epsin 1 helix is inserted into one leaflet of the lipid bilayer, inducing curvature; on lipid monolayers epsin alone is sufficient to facilitate the formation of clathrin-coated invaginations
Title: Curvature of clathrin-coated pits driven by epsin.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables clathrin adaptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables clathrin binding	IBA Inferred from Biological aspect of Ancestor more info
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables molecular sequestering activity	ISO Inferred from Sequence Orthology more info
enables phospholipid binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transmembrane transporter binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in Notch signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within Notch signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in clathrin coat assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in embryonic organ development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within embryonic organ development	ISO Inferred from Sequence Orthology more info
involved_in endocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in endocytosis	IDA Inferred from Direct Assay more info	PubMed
involved_in female pregnancy	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within female pregnancy	ISO Inferred from Sequence Orthology more info
involved_in in utero embryonic development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within in utero embryonic development	ISO Inferred from Sequence Orthology more info
involved_in membrane fission	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of sprouting angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of clathrin coat assembly	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in Schaffer collateral - CA1 synapse	IDA Inferred from Direct Assay more info	PubMed
part_of clathrin vesicle coat	IBA Inferred from Biological aspect of Ancestor more info
located_in clathrin-coated pit	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
is_active_in endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynapse	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
located_in presynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
located_in terminal bouton	HDA more info	PubMed

General protein information

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Preferred Names: epsin-1

Names: EPS-15-interacting protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_057136.2 → NP_476477.1 epsin-1

See identical proteins and their annotated locations for NP_476477.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

O88339

UniProtKB/TrEMBL

A0A140TAC3, A6KNR8

Related

ENSRNOP00000021286.4, ENSRNOT00000021286.7

Conserved Domains (2) summary

PRK07764
Location:270 → 437

PRK07764; DNA polymerase III subunits gamma and tau; Validated

cd16990
Location:19 → 142

ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family