Ftl1 ferritin light chain 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ftl1provided by RGD
Official Full Name: ferritin light chain 1provided by RGD
Primary source: RGD:61813
See related: EnsemblRapid:ENSRNOG00000064385 AllianceGenome:RGD:61813
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ftl
Summary: Predicted to enable ferric iron binding activity; ferrous iron binding activity; and identical protein binding activity. Involved in response to lead ion. Predicted to be located in autolysosome. Predicted to be part of ferritin complex. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in basal ganglia disease; hyperferritinemia-cataract syndrome; neurodegeneration with brain iron accumulation 3; and neurodegenerative disease. Orthologous to human FTL (ferritin light chain). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 7228.0), Spleen (RPKM 5625.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q22

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (105072858..105074705, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (95936387..95938234, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (101448190..101450034, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Ferritin light chain deficiency-induced ferroptosis is involved in preeclampsia pathophysiology by disturbing uterine spiral artery remodelling.
Title: Ferritin light chain deficiency-induced ferroptosis is involved in preeclampsia pathophysiology by disturbing uterine spiral artery remodelling.
Tissue-Specific Ferritin- and GFP-Based Genetic Vectors Visualize Neurons by MRI in the Intact and Post-Ischemic Rat Brain.
Title: Tissue-Specific Ferritin- and GFP-Based Genetic Vectors Visualize Neurons by MRI in the Intact and Post-Ischemic Rat Brain.
Reference intervals established using indirect method for serum ferritin assayed on Abbott Architect i2000SR analyzer in Chinese adults.
Title: Reference intervals established using indirect method for serum ferritin assayed on Abbott Architect i2000(SR) analyzer in Chinese adults.
FTL can be used as a serum marker for early phase radiation-induced liver damage.
Title: Differential regulation of ferritin subunits and iron transport proteins: an effect of targeted hepatic X-irradiation.
Data suggest that soluble transferrin receptor (sTfR) indices and the ratio of sTfR/ferritin could be useful indicators for monitoring iron deficiency during endurance training.
Title: The ratio of sTfR/ferritin is associated with the expression level of TfR in rat bone marrow cells after endurance exercise.
Ftl expression in rat hepatocytes and Kupffer cells after lead nitrate treatment is reported.
Title: Ferritin expression in rat hepatocytes and Kupffer cells after lead nitrate treatment.
Up-regulation of the expression of Ft-L could represent a protective response to the increased oxidative stress in the aging myocardium.
Title: Iron, ferritin and proteins of the methionine-centered redox cycle in young and old rat hearts.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Ftl1 (e-PCR), detects polymorphism
- UniSTS:532424

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ferric iron binding	IBA Inferred from Biological aspect of Ancestor more info
enables ferric iron binding	IEA Inferred from Electronic Annotation more info
enables ferrous iron binding	IBA Inferred from Biological aspect of Ancestor more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables iron ion binding	ISO Inferred from Sequence Orthology more info
enables iron ion binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in intracellular iron ion homeostasis	IEA Inferred from Electronic Annotation more info
involved_in intracellular iron ion homeostasis	TAS Traceable Author Statement more info	PubMed
involved_in iron ion transport	IEA Inferred from Electronic Annotation more info
involved_in response to lead ion	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in autolysosome	IEA Inferred from Electronic Annotation more info
located_in autolysosome	ISO Inferred from Sequence Orthology more info
located_in autophagosome	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
part_of ferritin complex	ISO Inferred from Sequence Orthology more info
part_of ferritin complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: ferritin light chain 1

Names: ferritin L subunit 1; ferritin, light polypeptide

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.