Kcnc2 potassium voltage-gated channel subfamily C member 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Kcnc2provided by RGD
Official Full Name: potassium voltage-gated channel subfamily C member 2provided by RGD
Primary source: RGD:628829
See related: EnsemblRapid:ENSRNOG00000004077 AllianceGenome:RGD:628829
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Kv3.2; KShIIIA
Summary: Enables delayed rectifier potassium channel activity; transmembrane transporter binding activity; and voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential. Involved in several processes, including cellular response to nitric oxide; nervous system development; and protein complex oligomerization. Located in several cellular components, including axon; basolateral plasma membrane; and neuronal cell body membrane. Part of voltage-gated potassium channel complex. Is active in GABA-ergic synapse and presynaptic membrane. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 103. Orthologous to human KCNC2 (potassium voltage-gated channel subfamily C member 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 187.0) and Adrenal (RPKM 92.0) See more
Orthologs: human mouse all
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Genomic context

Location:: 7q22

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (49586274..49770212)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (47700035..47883979)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (54978453..55159362)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In the absence of potassium ion, significant N-methyl-D-glucamine (NMDG)-positive currents could be recorded from human embryonic kidney cells expressing Kv3.1 or Kv3.2b channels and Kv1.5 Arg487Tyr/Val, but not wild-type channels.
Title: Control of voltage-gated K+ channel permeability to NMDG+ by a residue at the outer pore.
The results suggest that an altered expression of Kv3 channels affects the functional properties of FS neurons, and may contribute to the deficits in inhibition observed in the sensory-deprived cortex.
Title: Visual experience regulates Kv3.1b and Kv3.2 expression in developing rat visual cortex.
data provide the first description of Kv3 gating currents and give further insight into the interaction of BDS toxins and Kv3 channels
Title: Gating currents from a Kv3 subfamily potassium channel: charge movement and modification by BDS-II toxin.
The significance of Kv3.2 expression in some parvalbumin+ and somatostatin+ interneurons in the amygdala is not determined
Title: Differential expression of Kv3.1b and Kv3.2 potassium channel subunits in interneurons of the basolateral amygdala.
Kv3-like currents may be important for maintaining spike width and calcium influx within acceptable limits during repetitive firing.
Title: High-threshold, Kv3-like potassium currents in magnocellular neurosecretory neurons and their role in spike repolarization.
strong, selective localization of Kv3.2 to basket cell axons of cerebellum.
Title: Potassium channel subunit Kv3.2 and the water channel aquaporin-4 are selectively localized to cerebellar pinceau.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D7Rat169 (e-PCR), detects polymorphism
- UniSTS:228120

AU026734 (e-PCR)
- UniSTS:113989

BF404636 (e-PCR)
- UniSTS:247153

AU046555 (e-PCR)
- UniSTS:111338

D7Rat26 (e-PCR)
- UniSTS:119028

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables delayed rectifier potassium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables delayed rectifier potassium channel activity	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transmembrane transporter binding	IPI Inferred from Physical Interaction more info	PubMed
enables transmembrane transporter binding	ISO Inferred from Sequence Orthology more info
enables voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	IDA Inferred from Direct Assay more info	PubMed
enables voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	IMP Inferred from Mutant Phenotype more info	PubMed
enables voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	NAS Non-traceable Author Statement more info	PubMed
enables voltage-gated potassium channel activity	IDA Inferred from Direct Assay more info	PubMed
enables voltage-gated potassium channel activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in action potential	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within action potential	ISO Inferred from Sequence Orthology more info
involved_in cellular response to ammonium ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to nitric oxide	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to toxic substance	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to toxic substance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in globus pallidus development	IEP Inferred from Expression Pattern more info	PubMed
involved_in membrane hyperpolarization	ISO Inferred from Sequence Orthology more info
involved_in membrane hyperpolarization	ISS Inferred from Sequence or Structural Similarity more info
involved_in monoatomic ion transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in nitric oxide-cGMP-mediated signaling	IDA Inferred from Direct Assay more info	PubMed
involved_in optic nerve development	IEP Inferred from Expression Pattern more info	PubMed
involved_in positive regulation of potassium ion transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of voltage-gated potassium channel activity	IDA Inferred from Direct Assay more info	PubMed
involved_in potassium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in potassium ion transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in potassium ion transport	IDA Inferred from Direct Assay more info	PubMed
involved_in potassium ion transport	ISO Inferred from Sequence Orthology more info
involved_in protein heterooligomerization	IDA Inferred from Direct Assay more info	PubMed
involved_in protein homooligomerization	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of action potential firing rate	ISO Inferred from Sequence Orthology more info
involved_in regulation of action potential firing rate	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of presynaptic membrane potential	IEA Inferred from Electronic Annotation more info
involved_in response to amine	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to ethanol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to light intensity	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to magnesium ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to nerve growth factor	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to organic cyclic compound	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to toxic substance	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
is_active_in GABA-ergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in axolemma	IDA Inferred from Direct Assay more info	PubMed
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in axon	ISO Inferred from Sequence Orthology more info
is_active_in axon terminus	IBA Inferred from Biological aspect of Ancestor more info
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cell body	ISO Inferred from Sequence Orthology more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite	ISO Inferred from Sequence Orthology more info
is_active_in dendrite membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
is_active_in neuronal cell body membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in neuronal cell body membrane	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body membrane	ISO Inferred from Sequence Orthology more info
located_in perikaryon	IDA Inferred from Direct Assay more info	PubMed
located_in perikaryon	ISO Inferred from Sequence Orthology more info
located_in perikaryon	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in postsynaptic membrane	ISO Inferred from Sequence Orthology more info
located_in postsynaptic membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in presynaptic membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in presynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
located_in presynaptic membrane	ISO Inferred from Sequence Orthology more info
located_in presynaptic membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in synapse	IDA Inferred from Direct Assay more info	PubMed
located_in terminal bouton	IDA Inferred from Direct Assay more info	PubMed
located_in vesicle	IDA Inferred from Direct Assay more info	PubMed
part_of voltage-gated potassium channel complex	IBA Inferred from Biological aspect of Ancestor more info
part_of voltage-gated potassium channel complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: voltage-gated potassium channel KCNC2; potassium voltage-gated channel subfamily C member 2

Names: potassium channel voltage-gated Shaw-related subfamily C member 2; potassium voltage gated channel, Shaw-related subfamily, member 2; shaw-like potassium channel; voltage-gated potassium channel subunit Kv3.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_139216.1 → NP_631962.1 voltage-gated potassium channel KCNC2 isoform a

See identical proteins and their annotated locations for NP_631962.1

Status: PROVISIONAL

Description

Transcript Variant: This variant (a) includes alternate penultimate exons, compared to variant b, resulting in a novel 3' coding region and longer 3' UTR. It encodes isoform a which has a distinct C-terminus, compared to isoform b.

Source sequence(s)

M34052

UniProtKB/TrEMBL

A6IGI6, A6IGJ0

Conserved Domains (2) summary

cd18415
Location:7 → 166

BTB_KCNC2_4; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily C members KCNC2 and KCNC4

pfam00520
Location:228 → 484

Ion_trans; Ion transport protein
NM_139217.1 → NP_631963.1 voltage-gated potassium channel KCNC2 isoform b

See identical proteins and their annotated locations for NP_631963.1

Status: PROVISIONAL

Description

Transcript Variant: This variant (b) encodes the longer isoform (b).

Source sequence(s)

M59211

UniProtKB/Swiss-Prot

P22461, P22462, P22463, Q63735

UniProtKB/TrEMBL

A6IGI6, A6IGJ3

Conserved Domains (4) summary

smart00225
Location:10 → 159

BTB; Broad-Complex, Tramtrack and Bric a brac

pfam00520
Location:277 → 484

Ion_trans; Ion transport protein

pfam02214
Location:10 → 151

BTB_2; BTB/POZ domain

pfam07885
Location:427 → 474

Ion_trans_2; Ion channel

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

49586274..49770212

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039078413.2 → XP_038934341.1 potassium voltage-gated channel subfamily C member 2 isoform X5

UniProtKB/TrEMBL

A6IGI6, A6IGJ4

Conserved Domains (2) summary

cd18415
Location:7 → 166

BTB_KCNC2_4; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily C members KCNC2 and KCNC4

pfam00520
Location:228 → 484

Ion_trans; Ion transport protein
XM_039078416.2 → XP_038934344.1 potassium voltage-gated channel subfamily C member 2 isoform X5

UniProtKB/TrEMBL

A6IGI6, A6IGJ4

Conserved Domains (2) summary

cd18415
Location:7 → 166

BTB_KCNC2_4; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily C members KCNC2 and KCNC4

pfam00520
Location:228 → 484

Ion_trans; Ion transport protein
XM_017594661.3 → XP_017450150.1 potassium voltage-gated channel subfamily C member 2 isoform X2

UniProtKB/TrEMBL

A6IGI6

Related

ENSRNOP00000084708.1, ENSRNOT00000099049.2
XM_006241327.5 → XP_006241389.1 potassium voltage-gated channel subfamily C member 2 isoform X1

See identical proteins and their annotated locations for XP_006241389.1

UniProtKB/Swiss-Prot

P22461, P22462, P22463, Q63735

UniProtKB/TrEMBL

A6IGI6, A6IGJ3

Conserved Domains (4) summary

smart00225
Location:10 → 159

BTB; Broad-Complex, Tramtrack and Bric a brac

pfam00520
Location:277 → 484

Ion_trans; Ion transport protein

pfam02214
Location:10 → 151

BTB_2; BTB/POZ domain

pfam07885
Location:427 → 474

Ion_trans_2; Ion channel
XM_039078411.2 → XP_038934339.1 potassium voltage-gated channel subfamily C member 2 isoform X4

UniProtKB/TrEMBL

A6IGI6, A6IGJ0

Related

ENSRNOP00000005690.2, ENSRNOT00000005690.6

Conserved Domains (2) summary

cd18415
Location:7 → 166

BTB_KCNC2_4; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily C members KCNC2 and KCNC4

pfam00520
Location:228 → 484

Ion_trans; Ion transport protein
XM_017594662.3 → XP_017450151.1 potassium voltage-gated channel subfamily C member 2 isoform X3

UniProtKB/TrEMBL

A6IGI6, A6IGI7

Conserved Domains (4) summary

smart00225
Location:10 → 159

BTB; Broad-Complex, Tramtrack and Bric a brac

pfam00520
Location:277 → 484

Ion_trans; Ion transport protein

pfam02214
Location:10 → 151

BTB_2; BTB/POZ domain

pfam07885
Location:427 → 474

Ion_trans_2; Ion channel
XM_039078412.2 → XP_038934340.1 potassium voltage-gated channel subfamily C member 2 isoform X5

UniProtKB/TrEMBL

A6IGI6, A6IGJ4

Related

ENSRNOP00000005773.5, ENSRNOT00000005773.9

Conserved Domains (2) summary

cd18415
Location:7 → 166

BTB_KCNC2_4; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily C members KCNC2 and KCNC4

pfam00520
Location:228 → 484

Ion_trans; Ion transport protein
XM_017594660.3 → XP_017450149.1 potassium voltage-gated channel subfamily C member 2 isoform X1

UniProtKB/Swiss-Prot

P22461, P22462, P22463, Q63735

UniProtKB/TrEMBL

A6IGI6, A6IGJ3