Plcg1 phospholipase C, gamma 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Plcg1provided by RGD
Official Full Name: phospholipase C, gamma 1provided by RGD
Primary source: RGD:3347
See related: EnsemblRapid:ENSRNOG00000051490 AllianceGenome:RGD:3347
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: PPLCA
Summary: Enables several functions, including guanyl-nucleotide exchange factor activity; insulin receptor binding activity; and phospholipase C activity. Involved in several processes, including inositol trisphosphate biosynthetic process; phosphatidylinositol catabolic process; and regulation of store-operated calcium channel activity. Located in clathrin-coated vesicle. Biomarker of acute myocardial infarction and colon cancer. Human ortholog(s) of this gene implicated in hepatocellular carcinoma and lung non-small cell carcinoma. Orthologous to human PLCG1 (phospholipase C gamma 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 269.3), Thymus (RPKM 181.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q42

Exon count:: 32

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (169805299..169836040)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (149385587..149416330)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (156727642..156758307)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PLCgamma1 deficiency in chondrocytes accelerates the age-related changes in articular cartilage and subchondral bone.
Title: PLCγ1 deficiency in chondrocytes accelerates the age-related changes in articular cartilage and subchondral bone.
Methylation-mediated silencing of PTPRD induces pulmonary hypertension by promoting pulmonary arterial smooth muscle cell migration via the PDGFRB/PLCgamma1 axis.
Title: Methylation-mediated silencing of PTPRD induces pulmonary hypertension by promoting pulmonary arterial smooth muscle cell migration via the PDGFRB/PLCγ1 axis.
Suppressing PLCgamma1 enhances osteogenic and chondrogenic potential of BMSCs.
Title: Suppressing PLCγ1 enhances osteogenic and chondrogenic potential of BMSCs.
Smooth muscle PLCgamma1-Akt-mediated Notch1 signaling is crucial for intima formation in vascular injury.
Title: Phospholipase Cγ1 Mediates Intima Formation Through Akt-Notch1 Signaling Independent of the Phospholipase Activity.
These findings indicate that c-Jun induces PLCgamma1 expression transcriptionally and enhances rapid epithelial restitution after injury by activating Ca(2+) signal.
Title: c-Jun enhances intestinal epithelial restitution after wounding by increasing phospholipase C-γ1 transcription.
periodic mechanical stress induced ECM expression and the migration of NP cells via upregulating the expression of integrin alpha1 and the phosphorylation of downstream PLCgamma1. These findings provide novel information to aid the understanding of the pathogenesis and development of IDD.
Title: Periodic mechanical stress induces the extracellular matrix expression and migration of rat nucleus pulposus cells by upregulating the expression of intergrin α1 and phosphorylation of downstream phospholipase Cγ1.
These results suggest that colitis-induced and brain-derived neurotrophic factor-mediated calcitonin generelated peptide expression in sensory activation is regulated by a unique pathway involving brain-derived neurotrophic factorphospholipase C gamma-cAMP-responsive element binding protein axis.
Title: EXPRESS: Phospholipase C gamma mediates endogenous brain-derived neurotrophic factor - regulated calcitonin gene-related peptide expression in colitis - induced visceral pain.
FGFR1/2 act in concert to recruit and transphosphorylate phospholipase Cgamma1.
Title: Two FGF Receptor Kinase Molecules Act in Concert to Recruit and Transphosphorylate Phospholipase Cγ.
PDGF activates the GIT1PLCG1mediated ERK1/2 pathway to control chondrocyte proliferation.
Title: PDGF regulates chondrocyte proliferation through activation of the GIT1- and PLCγ1-mediated ERK1/2 signaling pathway.
The content of Na(+) and K(+) in the diet regulated chromosome X levels in endothelial cells and activated PLC-gamma1 levels in rats
Title: Sodium and potassium regulate endothelial phospholipase C-γ and Bmx.

Submit: New GeneRIF Correction See all GeneRIFs (56)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC20311P1 (e-PCR)
- UniSTS:271897

Plcg1 (e-PCR), detects polymorphism
- UniSTS:532520

Plcg1 (e-PCR), detects polymorphism
- UniSTS:144221

ksks435 (e-PCR)
- UniSTS:514492

RH94494 (e-PCR)
- UniSTS:119742

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables calcium-dependent phospholipase C activity	IDA Inferred from Direct Assay more info	PubMed
enables glutamate receptor binding	IEA Inferred from Electronic Annotation more info
enables glutamate receptor binding	ISO Inferred from Sequence Orthology more info
enables guanyl-nucleotide exchange factor activity	IDA Inferred from Direct Assay more info	PubMed
enables insulin receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables neurotrophin TRKA receptor binding	IEA Inferred from Electronic Annotation more info
enables neurotrophin TRKA receptor binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol phospholipase C activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol phospholipase C activity	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidylinositol phospholipase C activity	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol phospholipase C activity	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol phospholipase C activity	TAS Traceable Author Statement more info
enables phospholipase C activity	ISO Inferred from Sequence Orthology more info
enables phosphoprotein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables receptor tyrosine kinase binding	IEA Inferred from Electronic Annotation more info
enables receptor tyrosine kinase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in T cell receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within T cell receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in calcium ion transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in calcium-mediated signaling	IEA Inferred from Electronic Annotation more info
involved_in calcium-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in cell migration	IEA Inferred from Electronic Annotation more info
involved_in cell migration	ISO Inferred from Sequence Orthology more info
involved_in cellular response to epidermal growth factor stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to epidermal growth factor stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to epidermal growth factor stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in epidermal growth factor receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in epidermal growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in epidermal growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in in utero embryonic development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within in utero embryonic development	ISO Inferred from Sequence Orthology more info
involved_in inositol trisphosphate biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in inositol trisphosphate metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
involved_in modulation of chemical synaptic transmission	IEA Inferred from Electronic Annotation more info
involved_in modulation of chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylinositol catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in phosphatidylinositol metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidylinositol metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in phosphatidylinositol-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in phospholipid catabolic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of blood vessel endothelial cell migration	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of blood vessel endothelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of endothelial cell apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of endothelial cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of epithelial cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of epithelial cell migration	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of epithelial cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of epithelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of release of sequestered calcium ion into cytosol	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of release of sequestered calcium ion into cytosol	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vascular endothelial cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of vascular endothelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in regulation of store-operated calcium channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in release of sequestered calcium ion into cytosol	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to curcumin	IDA Inferred from Direct Assay more info	PubMed
involved_in response to gravity	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to hydrogen peroxide	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
part_of COP9 signalosome	IEA Inferred from Electronic Annotation more info
part_of COP9 signalosome	ISO Inferred from Sequence Orthology more info
part_of COP9 signalosome	ISS Inferred from Sequence or Structural Similarity more info
located_in Schaffer collateral - CA1 synapse	IEA Inferred from Electronic Annotation more info
is_active_in Schaffer collateral - CA1 synapse	ISO Inferred from Sequence Orthology more info
located_in cell projection	ISO Inferred from Sequence Orthology more info
located_in cell-cell junction	IEA Inferred from Electronic Annotation more info
located_in cell-cell junction	ISO Inferred from Sequence Orthology more info
located_in clathrin-coated vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in lamellipodium	IEA Inferred from Electronic Annotation more info
located_in lamellipodium	ISO Inferred from Sequence Orthology more info
located_in lamellipodium	ISS Inferred from Sequence or Structural Similarity more info
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	TAS Traceable Author Statement more info
located_in ruffle	ISO Inferred from Sequence Orthology more info
located_in ruffle	ISS Inferred from Sequence or Structural Similarity more info
is_active_in ruffle membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in ruffle membrane	IEA Inferred from Electronic Annotation more info
is_active_in ruffle membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

Names: PLC-148; PLC-II; PLC-gamma-1; phosphoinositide phospholipase C; phosphoinositide phospholipase C-gamma-1

NP_037319.2

EC 3.1.4.11

XP_038960315.1

EC 3.1.4.11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_013187.2 → NP_037319.2 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000003

UniProtKB/Swiss-Prot

P10686

UniProtKB/TrEMBL

A6JWZ3, G3V845

Related

ENSRNOP00000069822.1, ENSRNOT00000078909.3

Conserved Domains (11) summary

smart00149
Location:954 → 1069

PLCYc; Phospholipase C, catalytic domain (part); domain Y

cd00275
Location:1087 → 1211

C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)

cd08592
Location:319 → 466

PI-PLCc_gamma; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-gamma

cd09932
Location:663 → 765

SH2_C-SH2_PLC_gamma_like; C-terminal Src homology 2 (C-SH2) domain in Phospholipase C gamma

cd10341
Location:545 → 649

SH2_N-SH2_PLC_gamma_like; N-terminal Src homology 2 (N-SH2) domain in Phospholipase C gamma

cd11970
Location:791 → 850

SH3_PLCgamma1; Src homology 3 domain of Phospholipase C (PLC) gamma 1

cd13234
Location:864 → 933

PHsplit_PLC_gamma; Phospholipase C-gamma Split pleckstrin homology (PH) domain

cd13362
Location:29 → 151

PH_PLC_gamma; Phospholipase C-gamma (PLC-gamma) pleckstrin homology (PH) domain

cd15898
Location:156 → 185

EFh_PI-PLC; EF-hand motif [structural motif]

cl28895
Location:156 → 306

EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes

cl17171
Location:489 → 523

PH-like; Pleckstrin homology-like domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

169805299..169836040

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039104387.2 → XP_038960315.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1

UniProtKB/TrEMBL

A6JWZ2

Conserved Domains (11) summary

smart00149
Location:954 → 1069

PLCYc; Phospholipase C, catalytic domain (part); domain Y

cd00275
Location:1087 → 1186

C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)

cd08592
Location:319 → 466

PI-PLCc_gamma; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-gamma

cd09932
Location:663 → 765

SH2_C-SH2_PLC_gamma_like; C-terminal Src homology 2 (C-SH2) domain in Phospholipase C gamma

cd10341
Location:545 → 649

SH2_N-SH2_PLC_gamma_like; N-terminal Src homology 2 (N-SH2) domain in Phospholipase C gamma

cd11970
Location:791 → 850

SH3_PLCgamma1; Src homology 3 domain of Phospholipase C (PLC) gamma 1

cd13234
Location:864 → 933

PHsplit_PLC_gamma; Phospholipase C-gamma Split pleckstrin homology (PH) domain

cd13362
Location:29 → 151

PH_PLC_gamma; Phospholipase C-gamma (PLC-gamma) pleckstrin homology (PH) domain

cd15898
Location:156 → 185

EFh_PI-PLC; EF-hand motif [structural motif]

cl28895
Location:156 → 306

EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes

cl17171
Location:489 → 523

PH-like; Pleckstrin homology-like domain