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    Nudt7 nudix hydrolase 7 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361413, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nudt7provided by RGD
    Official Full Name
    nudix hydrolase 7provided by RGD
    Primary source
    RGD:1306719
    See related
    EnsemblRapid:ENSRNOG00000011976 AllianceGenome:RGD:1306719
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable coenzyme A diphosphatase activity; magnesium ion binding activity; and snoRNA binding activity. Predicted to be involved in nucleoside phosphate catabolic process. Predicted to act upstream of or within acetyl-CoA catabolic process and brown fat cell differentiation. Predicted to be active in peroxisome. Orthologous to human NUDT7 (nudix hydrolase 7). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 62.7), Heart (RPKM 60.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Nudt7 in Genome Data Viewer
    Location:
    19q12
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (59034808..59049148)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (42125679..42151198)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (46455745..46470070)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA40 Neighboring gene ADAM metallopeptidase with thrombospondin type 1 motif, 18 Neighboring gene S-phase kinase-associated protein 1, pseudogene 2 Neighboring gene vesicle amine transport 1-like Neighboring gene C-type lectin domain family 3, member A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Mammalian NADH diphosphatases of the Nudix family: cloning and characterization of the human peroxisomal NUDT12 protein. Abdelraheim SR, et al. Biochem J, 2003 Sep 1. PMID 12790796, Free PMC Article
    2. The mouse Nudt7 gene encodes a peroxisomal nudix hydrolase specific for coenzyme A and its derivatives. Gasmi L, et al. Biochem J, 2001 Jul 1. PMID 11415433, Free PMC Article
    3. Multiple mRNA decapping enzymes in mammalian cells. Song MG, et al. Mol Cell, 2010 Nov 12. PMID 21070968, Free PMC Article
    4. Wdnm1-like, a new adipokine with a role in MMP-2 activation. Wu Y, et al. Am J Physiol Endocrinol Metab, 2008 Jul. PMID 18492766, Free PMC Article
    5. A proteome-wide perspective on peroxisome targeting signal 1(PTS1)-Pex5p affinities. Ghosh D, et al. J Am Chem Soc, 2010 Mar 24. PMID 20178365

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    NOT enables 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables coenzyme A diphosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables magnesium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables manganese ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables snoRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within acetyl-CoA catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in acetyl-CoA catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within brown fat cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in butyryl-CoA catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in coenzyme A catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within coenzyme A catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in coenzyme A catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in malonyl-CoA catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in medium-chain fatty-acyl-CoA catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nucleoside diphosphate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in propionyl-CoA catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in propionyl-CoA metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in succinyl-CoA catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in peroxisome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in peroxisome ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    peroxisomal coenzyme A diphosphatase NUDT7
    Names
    nudix (nucleoside diphosphate linked moiety X)-type motif 7
    nudix motif 7
    peroxisomal coenzyme A diphosphatase NUDT7-like
    NP_001292355.1
    NP_001292356.1
    XP_017456810.1
    XP_038953791.1
    XP_038953792.2
    XP_063134209.1
    XP_063134210.1
    XP_063134211.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001305426.1 → NP_001292355.1  peroxisomal coenzyme A diphosphatase NUDT7 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript but encodes the longer isoform (1).
      Source sequence(s)
      FM098914, FM122430, JAXUCZ010000019
      UniProtKB/TrEMBL
      A0A1W2Q6B7
      Conserved Domains (1) summary
      cd03426
      Location:41 → 192
      CoAse; Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative ...

    2. NM_001305427.1 → NP_001292356.1  peroxisomal coenzyme A diphosphatase NUDT7 isoform 2

      See identical proteins and their annotated locations for NP_001292356.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) includes an alternate exon in its 5' UTR and CDS which results in the use of an alternate start codon, compared to variant 1. The encoded isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      CB582462, FM122430, FM141049, JAXUCZ010000019
      UniProtKB/TrEMBL
      A6IZE0
      Conserved Domains (1) summary
      cd03426
      Location:13 → 142
      CoAse; Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      59034808..59049148
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063278139.1 → XP_063134209.1  peroxisomal coenzyme A diphosphatase NUDT7 isoform X1

      UniProtKB/TrEMBL
      A6IZD7

    2. XM_063278140.1 → XP_063134210.1  peroxisomal coenzyme A diphosphatase NUDT7 isoform X2

      UniProtKB/TrEMBL
      A6IZD7, D3ZV74
      Related
      ENSRNOP00000032779.6, ENSRNOT00000034012.8

    3. XM_063278141.1 → XP_063134211.1  peroxisomal coenzyme A diphosphatase NUDT7 isoform X4

      UniProtKB/TrEMBL
      A6IZD7

    4. XM_039097863.1 → XP_038953791.1  peroxisomal coenzyme A diphosphatase NUDT7 isoform X3

      UniProtKB/TrEMBL
      A6IZD7
      Related
      ENSRNOP00000076192.3, ENSRNOT00000093238.3
      Conserved Domains (1) summary
      cd03426
      Location:65 → 241
      CoAse; Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative ...

    5. XM_017601321.2 → XP_017456810.1  peroxisomal coenzyme A diphosphatase NUDT7 isoform X5

      UniProtKB/TrEMBL
      A6IZD7, A6IZD8
      Related
      ENSRNOP00000103127.1, ENSRNOT00000133063.1
      Conserved Domains (1) summary
      cd03426
      Location:65 → 196
      CoAse; Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative ...

    6. XM_039097864.2 → XP_038953792.2  peroxisomal coenzyme A diphosphatase NUDT7 isoform X6

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001108450.1: Suppressed sequence

      Description
      NM_001108450.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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