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    Guk1 guanylate kinase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 303179, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Guk1provided by RGD
    Official Full Name
    guanylate kinase 1provided by RGD
    Primary source
    RGD:1309638
    See related
    EnsemblRapid:ENSRNOG00000002928 AllianceGenome:RGD:1309638
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables guanylate kinase activity. Involved in glycoprotein transport; nucleoside phosphate metabolic process; and phosphorylation. Predicted to be located in mitochondrion and photoreceptor inner segment. Predicted to be active in cytosol. Orthologous to human GUK1 (guanylate kinase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 210.0), Heart (RPKM 194.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Guk1 in Genome Data Viewer
    Location:
    10q22
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (44471075..44488332, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (43971514..43988658, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (45535617..45552455, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene iron-sulfur cluster assembly factor IBA57 Neighboring gene gap junction protein, gamma 2 Neighboring gene mitochondrial ribosomal protein L55 Neighboring gene similar to human chromosome 1 open reading frame 35 Neighboring gene ARF GTPase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A microsomal GTPase is required for glycopeptide export from the mammalian endoplasmic reticulum. Ali BR, et al. J Biol Chem, 2000 Oct 27. PMID 10913137
    2. Structural characterization of the closed conformation of mouse guanylate kinase. Sekulic N, et al. J Biol Chem, 2002 Aug 16. PMID 12036965
    3. 9-([2-hydroxy-1-(hydroxymethyl)ethoxy]methyl)guanine: a selective inhibitor of herpes group virus replication. Field AK, et al. Proc Natl Acad Sci U S A, 1983 Jul. PMID 6306664, Free PMC Article
    4. Partial purification and properties of ATP:GMP phosphransferase from rat liver. Buccino RJ Jr, et al. Arch Biochem Biophys, 1969 Jun. PMID 4307347
    5. Solution structure and functional investigation of human guanylate kinase reveals allosteric networking and a crucial role for the enzyme in cancer. Khan N, et al. J Biol Chem, 2019 Aug 2. PMID 31201273, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables guanylate kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanylate kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables guanylate kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nucleoside monophosphate kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in GDP biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in GDP-mannose metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in GMP metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in dATP metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in dGDP biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in dGDP biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in dGMP metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in glycoprotein transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in purine nucleotide metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in xenobiotic metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in photoreceptor inner segment ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    guanylate kinase
    Names
    ATP:GMP-phosphotransferase
    NP_001013133.2
    XP_006246539.1
    XP_063125059.1
    XP_063125060.1
    XP_063125061.1
    XP_063125062.1
    XP_063125063.1
    XP_063125064.1
    XP_063125065.1
    XP_063125066.1
    XP_063125067.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013115.3 → NP_001013133.2  guanylate kinase

      See identical proteins and their annotated locations for NP_001013133.2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A0A8I5ZT32, A6HEY0
      Related
      ENSRNOP00000003926.7, ENSRNOT00000003926.8
      Conserved Domains (2) summary
      TIGR03263
      Location:26 → 208
      guanyl_kin; guanylate kinase
      pfam00625
      Location:24 → 209
      Guanylate_kin; Guanylate kinase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      44471075..44488332 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063268991.1 → XP_063125061.1  guanylate kinase isoform X4

      UniProtKB/TrEMBL
      Q71RR7

    2. XM_063268992.1 → XP_063125062.1  guanylate kinase isoform X4

      UniProtKB/TrEMBL
      Q71RR7

    3. XM_063268990.1 → XP_063125060.1  guanylate kinase isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZT32, A0A8I6GLP0

    4. XM_006246477.5 → XP_006246539.1  guanylate kinase isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZT32, A0A8I6A2B3
      Conserved Domains (2) summary
      TIGR03263
      Location:73 → 255
      guanyl_kin; guanylate kinase
      pfam00625
      Location:71 → 256
      Guanylate_kin; Guanylate kinase

    5. XM_063268995.1 → XP_063125065.1  guanylate kinase isoform X7

    6. XM_063268993.1 → XP_063125063.1  guanylate kinase isoform X5

      UniProtKB/TrEMBL
      A0A8I5ZT32

    7. XM_063268989.1 → XP_063125059.1  guanylate kinase isoform X1

    8. XM_063268996.1 → XP_063125066.1  guanylate kinase isoform X8

      UniProtKB/TrEMBL
      A0A8I5ZT32

    9. XM_063268994.1 → XP_063125064.1  guanylate kinase isoform X6

    10. XM_063268997.1 → XP_063125067.1  guanylate kinase isoform X9

    Nucleotide Protein Strain
    Heading Accession and Version

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