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    Slc15a4 solute carrier family 15 member 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 246280, updated on 9-Dec-2024

    Summary

    Official Symbol
    Slc15a4provided by RGD
    Official Full Name
    solute carrier family 15 member 4provided by RGD
    Primary source
    RGD:708469
    See related
    EnsemblRapid:ENSRNOG00000000962 AllianceGenome:RGD:708469
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables L-histidine transmembrane transporter activity. Involved in histidine transport. Predicted to be located in early endosome membrane and endolysosome membrane. Predicted to be active in membrane. Orthologous to human SLC15A4 (solute carrier family 15 member 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 148.8), Kidney (RPKM 82.3) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Slc15a4 in Genome Data Viewer
    Location:
    12q14
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (34684583..34718429)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (29048634..29082480)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (32753824..32773277)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene transmembrane protein 132D Neighboring gene uncharacterized LOC134481288 Neighboring gene uncharacterized LOC134481183 Neighboring gene glycosyltransferase 1 domain containing 1 Neighboring gene uncharacterized LOC108352443 Neighboring gene transmembrane protein 132C Neighboring gene transmembrane protein 254, pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Markers

    Clone Names

    • MGC105315

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables L-histidine transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables L-histidine transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables L-histidine transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables L-histidine transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables L-histidine transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables dipeptide transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables dipeptide transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables dipeptide transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables dipeptide transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables peptide:proton symporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables peptide:proton symporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables peptide:proton symporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables peptidoglycan transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables peptidoglycan transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables peptidoglycan transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in L-histidine transmembrane export from vacuole IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in L-histidine transmembrane export from vacuole ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in dipeptide import across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in dipeptide import across plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in dipeptide import across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in dipeptide import across plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in histidine transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in histidine transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mast cell homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mast cell homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mast cell homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in peptidoglycan transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in peptidoglycan transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in peptidoglycan transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of innate immune response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of innate immune response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of toll-like receptor 7 signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of toll-like receptor 7 signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of toll-like receptor 7 signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of toll-like receptor 8 signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of toll-like receptor 8 signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of toll-like receptor 8 signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of toll-like receptor 9 signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of toll-like receptor 9 signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of toll-like receptor 9 signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of isotype switching to IgG isotypes IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of isotype switching to IgG isotypes ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of isotype switching to IgG isotypes ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in early endosome membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in early endosome membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endolysosome membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endolysosome membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endolysosome membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in endosome membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lysosomal membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lysosomal membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    solute carrier family 15 member 4
    Names
    peptide transporter 4
    peptide/histidine transporter 1
    rPHT1
    solute carrier family 15 (oligopeptide transporter), member 4

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_144758.1NP_653359.1  solute carrier family 15 member 4

      See identical proteins and their annotated locations for NP_653359.1

      Status: PROVISIONAL

      Source sequence(s)
      AB000280
      UniProtKB/Swiss-Prot
      O09014, Q5M931
      UniProtKB/TrEMBL
      A0A0G2JSH0, A6J0U3
      Related
      ENSRNOP00000001277.2, ENSRNOT00000001277.5
      Conserved Domains (1) summary
      cd17348
      Location:25555
      MFS_SLC15A3_4; Solute Carrier family 15 members 3 and 4 of the Major Facilitator Superfamily of transporters

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      34684583..34718429
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039089072.2XP_038945000.1  solute carrier family 15 member 4 isoform X3

      UniProtKB/TrEMBL
      A6J0U4
      Conserved Domains (1) summary
      cl28910
      Location:53295
      MFS; Major Facilitator Superfamily
    2. XM_039089071.2XP_038944999.1  solute carrier family 15 member 4 isoform X2

      Conserved Domains (1) summary
      cl28910
      Location:18390
      MFS; Major Facilitator Superfamily
    3. XM_039089070.2XP_038944998.1  solute carrier family 15 member 4 isoform X1

      Conserved Domains (1) summary
      cl28910
      Location:18390
      MFS; Major Facilitator Superfamily

    RNA

    1. XR_005491598.2 RNA Sequence