Mrgprd MAS related GPR family member D [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mrgprdprovided by RGD
Official Full Name: MAS related GPR family member Dprovided by RGD
Primary source: RGD:738040
See related: EnsemblRapid:ENSRNOG00000013448 AllianceGenome:RGD:738040
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Mgrd; Mrgd; TGR7
Summary: Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be active in plasma membrane. Orthologous to human MRGPRD (MAS related GPR family member D). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Uterus (RPKM 3.1), Testes (RPKM 1.2) and 3 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q42

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (209908487..209917183)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (200479204..200487902)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (218481146..218491910)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Alamandine through MrgD receptor induces antidepressant-like effect in transgenic rats with low brain angiotensinogen.
Title: Alamandine through MrgD receptor induces antidepressant-like effect in transgenic rats with low brain angiotensinogen.
Activation of recombinant rat MrgD protein promotes opening of the endogenous calcium-activated chloride channels in Xenopus oocytes.
Title: Mas-related G protein-coupled receptor D is coupled to endogenous calcium-activated chloride channel in Xenopus oocytes.
TGR7 participates in the modulation of neuropathic pain
Title: Identification of a G protein-coupled receptor specifically responsive to beta-alanine.
Interactions between rMrgD and rMrgE modulate the function of rMrgD.
Title: Interactions between the Mas-related receptors MrgD and MrgE alter signalling and trafficking of MrgD.
We provide evidence for a novel interaction between MrgD and KCNQ/M-type potassium channels that contributes to an increase in excitability of DRG neurons and thus may enhance the signaling of primary afferent nociceptive neurons.
Title: MrgD activation inhibits KCNQ/M-currents and contributes to enhanced neuronal excitability.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: mas-related G-protein coupled receptor member D

Names: G-protein coupled receptor TGR7; MAS-related G-protein coupled receptor, member D; MAS-related GPR, member D; MAS-related gene D; MRGD G protein-coupled receptor; Mas-related G protein-coupled receptor d; beta-alanine receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001001506.2 → NP_001001506.1 mas-related G-protein coupled receptor member D

See identical proteins and their annotated locations for NP_001001506.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

Q6L788, Q7TN41

UniProtKB/TrEMBL

W8W3F8

Related

ENSRNOP00000099226.1, ENSRNOT00000145954.1

Conserved Domains (2) summary

pfam00001
Location:43 → 278

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:36 → 211

7tm_4; Olfactory receptor