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    Tssk4 testis-specific serine kinase 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 290229, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tssk4provided by RGD
    Official Full Name
    testis-specific serine kinase 4provided by RGD
    Primary source
    RGD:1560814
    See related
    EnsemblRapid:ENSRNOG00000019789 AllianceGenome:RGD:1560814
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1560814
    Summary
    Predicted to enable several functions, including ATP binding activity; magnesium ion binding activity; and protein homodimerization activity. Predicted to be involved in several processes, including flagellated sperm motility; positive regulation of CREB transcription factor activity; and protein phosphorylation. Predicted to be located in sperm flagellum. Orthologous to human TSSK4 (testis specific serine kinase 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 33.7), Thymus (RPKM 17.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tssk4 in Genome Data Viewer
    Location:
    15p13
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (33108248..33114083)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (29140803..29144128)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (34322182..34331187)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene importin 4 Neighboring gene transmembrane 9 superfamily member 1 Neighboring gene magnesium-dependent phosphatase 1 Neighboring gene NEDD8 ubiquitin like modifier Neighboring gene guanosine monophosphate reductase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Testis specific serine/threonine kinase 4 (Tssk4) maintains its kinase activity by phosphorylating itself at Thr-197. Wei Y, et al. Mol Biol Rep, 2013 Jan. PMID 23054012
    2. Isolation and characterization of mouse testis specific serine/threonine kinase 5 possessing four alternatively spliced variants. Wei Y, et al. J Biochem Mol Biol, 2007 Sep 30. PMID 17927909
    3. Testis-specific serine/threonine protein kinase 4 (Tssk4) phosphorylates Odf2 at Ser-76. Wang X, et al. Sci Rep, 2016 Mar 10. PMID 26961893, Free PMC Article
    4. Phosphorylated testis-specific serine/threonine kinase 4 may phosphorylate Crem at Ser-117. Fu G, et al. Biosci Biotechnol Biochem, 2016 Jun. PMID 26940607
    5. TSSK5, a novel member of the testis-specific serine/threonine kinase family, phosphorylates CREB at Ser-133, and stimulates the CRE/CREB responsive pathway. Chen X, et al. Biochem Biophys Res Commun, 2005 Aug 5. PMID 15964553

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables magnesium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT enables protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in fertilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in flagellated sperm motility ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in peptidyl-threonine autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of CREB transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in spermatid development ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in motile cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in sperm flagellum ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    testis-specific serine/threonine-protein kinase 4
    NP_001258254.1
    NP_001400875.1
    XP_006252001.1
    XP_063130194.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271325.2 → NP_001258254.1  testis-specific serine/threonine-protein kinase 4 isoform 1

      See identical proteins and their annotated locations for NP_001258254.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the functional protein.
      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/TrEMBL
      A0A0G2QC55, A6KH29
      Related
      ENSRNOP00000026819.6, ENSRNOT00000026819.9
      Conserved Domains (2) summary
      smart00220
      Location:25 → 278
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:24 → 278
      PKc_like; Protein Kinases, catalytic domain

    2. NM_001413946.1 → NP_001400875.1  testis-specific serine/threonine-protein kinase 4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015

    RNA

    1. NR_073162.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate internal splice site, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      JAXUCZ010000015

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      33108248..33114083
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063274124.1 → XP_063130194.1  testis-specific serine/threonine-protein kinase 4 isoform X2

    2. XM_006251939.5 → XP_006252001.1  testis-specific serine/threonine-protein kinase 4 isoform X1

      See identical proteins and their annotated locations for XP_006252001.1

      UniProtKB/TrEMBL
      A6KH28
      Conserved Domains (2) summary
      smart00220
      Location:25 → 293
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14162
      Location:24 → 292
      STKc_TSSK4-like; Catalytic domain of testis-specific serine/threonine kinase 4 and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version

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