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    Fau FAU ubiquitin like and ribosomal protein S30 fusion [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29752, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Fauprovided by RGD
    Official Full Name
    FAU ubiquitin like and ribosomal protein S30 fusionprovided by RGD
    Primary source
    RGD:61938
    See related
    EnsemblRapid:ENSRNOG00000020982 AllianceGenome:RGD:61938
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable protein tag activity and ubiquitin protein ligase binding activity. Predicted to be a structural constituent of ribosome. Predicted to be involved in several processes, including defense response to other organism; protein ubiquitination; and ribosomal small subunit assembly. Predicted to be located in cytosolic ribosome and extracellular space. Predicted to be part of cytosolic small ribosomal subunit. Predicted to be active in cytoplasm and nucleus. Orthologous to human FAU (FAU ubiquitin like and ribosomal protein S30 fusion). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 3349.7), Thymus (RPKM 2896.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Fau in Genome Data Viewer
    Location:
    1q43
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (212779429..212781028)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (203350226..203351741)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (221420312..221421827)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene calpain 1 Neighboring gene uncharacterized LOC108349685 Neighboring gene synoviolin 1 Neighboring gene mitochondrial ribosomal protein L49 Neighboring gene zinc finger, HIT-type containing 2 Neighboring gene transmembrane 7 superfamily member 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The carboxyl extension of a ubiquitin-like protein is rat ribosomal protein S30. Olvera J, et al. J Biol Chem, 1993 Aug 25. PMID 8394356
    2. Ubiquicidin, a novel murine microbicidal protein present in the cytosolic fraction of macrophages. Hiemstra PS, et al. J Leukoc Biol, 1999 Sep. PMID 10496312
    3. Functional dichotomy of ribosomal proteins during the synthesis of mammalian 40S ribosomal subunits. O'Donohue MF, et al. J Cell Biol, 2010 Sep 6. PMID 20819938, Free PMC Article
    4. Antimicrobial peptides in the first line defence of human colon mucosa. Tollin M, et al. Peptides, 2003 Apr. PMID 12860195
    5. Mass spectrometric analysis of the human 40S ribosomal subunit: native and HCV IRES-bound complexes. Yu Y, et al. Protein Sci, 2005 Jun. PMID 15883184, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein tag activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural constituent of ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin protein ligase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in antimicrobial humoral immune response mediated by antimicrobial peptide ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in innate immune response in mucosa ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in modification-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ribosomal small subunit assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosolic ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of cytosolic small ribosomal subunit ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    40S ribosomal protein S30
    Names
    Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed (fox derived) protein
    Finkel-Biskis-Reilly murine sarcoma virusubiquitously expressed
    ribosomal protein S30
    ubiquitin-like protein FUBI

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012739.1 → NP_001012757.1  40S ribosomal protein S30 precursor

      See identical proteins and their annotated locations for NP_001012757.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1-3 encode the same protein.
      Source sequence(s)
      BC091402
      UniProtKB/TrEMBL
      A0A8I6A5S6, A0A9K3Y6P2, D4A7R8, Q5BJN7
      Related
      ENSRNOP00000028481.4, ENSRNOT00000028481.8
      Conserved Domains (2) summary
      cd01793
      Location:1 → 74
      Ubl_FUBI; ubiquitin-like (Ubl) domain found in ubiquitin-like protein FUBI and similar proteins
      pfam04758
      Location:75 → 132
      Ribosomal_S30; Ribosomal protein S30

    2. NM_001160231.1 → NP_001153703.1  40S ribosomal protein S30 precursor

      See identical proteins and their annotated locations for NP_001153703.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1-3 encode the same protein.
      Source sequence(s)
      BC091402, CB316435
      UniProtKB/TrEMBL
      A0A8I6A5S6, A0A9K3Y6P2, D4A7R8, Q5BJN7
      Conserved Domains (2) summary
      cd01793
      Location:1 → 74
      Ubl_FUBI; ubiquitin-like (Ubl) domain found in ubiquitin-like protein FUBI and similar proteins
      pfam04758
      Location:75 → 132
      Ribosomal_S30; Ribosomal protein S30

    3. NM_001160232.1 → NP_001153704.1  40S ribosomal protein S30 precursor

      See identical proteins and their annotated locations for NP_001153704.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1-3 encode the same protein.
      Source sequence(s)
      BC091402
      UniProtKB/TrEMBL
      A0A8I6A5S6, A0A9K3Y6P2, D4A7R8, Q5BJN7
      Conserved Domains (2) summary
      cd01793
      Location:1 → 74
      Ubl_FUBI; ubiquitin-like (Ubl) domain found in ubiquitin-like protein FUBI and similar proteins
      pfam04758
      Location:75 → 132
      Ribosomal_S30; Ribosomal protein S30

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      212779429..212781028
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063287966.1 → XP_063144036.1  40S ribosomal protein S30 isoform X1

    2. XM_063287956.1 → XP_063144026.1  40S ribosomal protein S30 isoform X1

    3. XM_063287976.1 → XP_063144046.1  40S ribosomal protein S30 isoform X2

      UniProtKB/TrEMBL
      A0A8I6A5S6, A0A9K3Y6P2, D4A7R8, Q5BJN7

    4. XM_063287968.1 → XP_063144038.1  40S ribosomal protein S30 isoform X1

    5. XM_063287971.1 → XP_063144041.1  40S ribosomal protein S30 isoform X1

    6. XM_063287978.1 → XP_063144048.1  40S ribosomal protein S30 isoform X2

      UniProtKB/TrEMBL
      A0A8I6A5S6, A0A9K3Y6P2, D4A7R8, Q5BJN7

    7. XM_063287974.1 → XP_063144044.1  40S ribosomal protein S30 isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P62864.1 GenPept UniProtKB/Swiss-Prot:P62864
    Q05474.1 GenPept UniProtKB/Swiss-Prot:Q05474

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