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    Gns glucosamine (N-acetyl)-6-sulfatase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 299825, updated on 9-Dec-2024

    Summary

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    Symbol
    Gnsprovided by RGD
    Full Name
    glucosamine (N-acetyl)-6-sulfataseprovided by RGD
    Primary source
    RGD:1305877
    See related
    EnsemblRapid:ENSRNOG00000046159 AllianceGenome:RGD:1305877
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables N-acetylglucosamine-6-sulfatase activity; glycosaminoglycan binding activity; and sulfate binding activity. Involved in keratan sulfate catabolic process. Predicted to be located in lysosome. Human ortholog(s) of this gene implicated in mucopolysaccharidosis III and mucopolysaccharidosis type IIID. Orthologous to human GNS (glucosamine (N-acetyl)-6-sulfatase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 895.1), Spleen (RPKM 395.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Gns in Genome Data Viewer
    Location:
    7q22
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (58774625..58808650)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (56889148..56923173)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (63467027..63501054)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene TBC1 domain family, member 30 Neighboring gene uncharacterized LOC120093619 Neighboring gene Ras association domain family member 3 Neighboring gene uncharacterized LOC134479702

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Intralysosomal formation and metabolic fate of N-acetylglucosamine 6-sulfate from keratan sulfate. Fuchs W, et al. Eur J Biochem, 1985 Sep 16. PMID 3161730
    2. Genomic basis of mucopolysaccharidosis type IIID (MIM 252940) revealed by sequencing of GNS encoding N-acetylglucosamine-6-sulfatase. Mok A, et al. Genomics, 2003 Jan. PMID 12573255
    3. Sulphatase activities are regulated by the interaction of sulphatase-modifying factor 1 with SUMF2. Zito E, et al. EMBO Rep, 2005 Jul. PMID 15962010, Free PMC Article
    4. Sulfatases and sulfatase modifying factors: an exclusive and promiscuous relationship. Sardiello M, et al. Hum Mol Genet, 2005 Nov 1. PMID 16174644
    5. Loss of CLN7 results in depletion of soluble lysosomal proteins and impaired mTOR reactivation. Danyukova T, et al. Hum Mol Genet, 2018 May 15. PMID 29514215, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables N-acetylglucosamine-6-sulfatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables N-acetylglucosamine-6-sulfatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glycosaminoglycan binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glycosaminoglycan binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sulfate binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sulfuric ester hydrolase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in keratan sulfate catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in lysosome ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    N-acetylglucosamine-6-sulfatase
    Names
    N-acetylglucosamine-6-sulfatase-like
    NP_001011989.1
    NP_001401851.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001011989.2 → NP_001011989.1  N-acetylglucosamine-6-sulfatase isoform 2 precursor

      See identical proteins and their annotated locations for NP_001011989.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      A0A8J8YF65, Q5M918
      Conserved Domains (2) summary
      COG3119
      Location:35 → 496
      AslA; Arylsulfatase A or related enzyme [Inorganic ion transport and metabolism]
      cd16147
      Location:38 → 487
      G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)

    2. NM_001414922.1 → NP_001401851.1  N-acetylglucosamine-6-sulfatase isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      A0A8J8YF65, F7EQ81, F7F393, Q32KJ5
      Related
      ENSRNOP00000062823.4, ENSRNOT00000064349.5

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      58774625..58808650
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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