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    Prss12 serine protease 12 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 85266, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Prss12provided by RGD
    Official Full Name
    serine protease 12provided by RGD
    Primary source
    RGD:69238
    See related
    EnsemblRapid:ENSRNOG00000015353 AllianceGenome:RGD:69238
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Nt
    Summary
    Predicted to enable serine-type endopeptidase activity. Predicted to be involved in exocytosis and zymogen activation. Predicted to act upstream of or within proteolysis. Predicted to be located in axon; cytoplasmic vesicle; and synapse. Predicted to be active in several cellular components, including Schaffer collateral - CA1 synapse; glutamatergic synapse; and synaptic cleft. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 1 and intellectual disability. Orthologous to human PRSS12 (serine protease 12). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 49.4), Lung (RPKM 38.7) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Prss12 in Genome Data Viewer
    Location:
    2q42
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (214308695..214368679)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (211624134..211684126)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (227657983..227717884)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene RNA, U6atac small nuclear Neighboring gene elongin B, pseduogene 2 Neighboring gene small nucleolar RNA SNORA24 Neighboring gene N-deacetylase and N-sulfotransferase 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. NMR solution structure of the neurotrypsin Kringle domain. Ozhogina OA, et al. Biochemistry, 2008 Nov 25. PMID 18956887, Free PMC Article
    2. Activity-induced synaptic capture and exocytosis of the neuronal serine protease neurotrypsin. Frischknecht R, et al. J Neurosci, 2008 Feb 13. PMID 18272678, Free PMC Article
    3. Enzymatic properties and localization of motopsin (PRSS12), a protease whose absence causes mental retardation. Mitsui S, et al. Brain Res, 2007 Mar 9. PMID 17223089
    4. Truncating neurotrypsin mutation in autosomal recessive nonsyndromic mental retardation. Molinari F, et al. Science, 2002 Nov 29. PMID 12459588
    5. Specific cleavage of agrin by neurotrypsin, a synaptic protease linked to mental retardation. Reif R, et al. FASEB J, 2007 Nov. PMID 17586728

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. NMR structure of neurotrypsin kringle domain
      Title: NMR solution structure of the neurotrypsin Kringle domain.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables peptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables serine-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in exocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in exocytosis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within proteolysis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within zymogen activation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Schaffer collateral - CA1 synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in axon ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in presynapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in synaptic cleft IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in synaptic cleft ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in terminal bouton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in terminal bouton ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    neurotrypsin
    Names
    peptidase, serine, 12 (neurotrypsin, motopsin)
    protease, serine 12
    protease, serine, 12 neurotrypsin (motopsin)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053504.1 → NP_445956.1  neurotrypsin precursor

      See identical proteins and their annotated locations for NP_445956.1

      Status: PROVISIONAL

      Source sequence(s)
      AJ311671
      UniProtKB/Swiss-Prot
      G3V801, Q99JC8
      Related
      ENSRNOP00000021116.3, ENSRNOT00000021116.5
      Conserved Domains (5) summary
      smart00020
      Location:516 → 755
      Tryp_SPc; Trypsin-like serine protease
      smart00130
      Location:83 → 159
      KR; Kringle domain
      smart00202
      Location:166 → 265
      SR; Scavenger receptor Cys-rich
      cd00190
      Location:517 → 758
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam00530
      Location:171 → 266
      SRCR; Scavenger receptor cysteine-rich domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      214308695..214368679
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    G3V801.1 GenPept UniProtKB/Swiss-Prot:G3V801

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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