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    Uhrf2 ubiquitin like with PHD and ring finger domains 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 309331, updated on 9-Dec-2024

    Summary

    Official Symbol
    Uhrf2provided by RGD
    Official Full Name
    ubiquitin like with PHD and ring finger domains 2provided by RGD
    Primary source
    RGD:1309990
    See related
    EnsemblRapid:ENSRNOG00000011308 AllianceGenome:RGD:1309990
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable RNA polymerase II-specific DNA-binding transcription factor binding activity; histone binding activity; and ubiquitin-like protein transferase activity. Predicted to be involved in several processes, including negative regulation of gene expression via chromosomal CpG island methylation; protein autoubiquitination; and regulation of cell cycle. Predicted to be located in nucleoplasm and pericentric heterochromatin. Orthologous to human UHRF2 (ubiquitin like with PHD and ring finger domains 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 340.5), Thymus (RPKM 243.2) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Uhrf2 in Genome Data Viewer
    Location:
    1q52
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (237224050..237291406)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (227814639..227877907)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (248228496..248291984)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120100019 Neighboring gene TPD52 like 3 Neighboring gene eukaryotic translation elongation factor 1 beta 2, pseudogene 3 Neighboring gene glycine decarboxylase Neighboring gene coiled-coil-helix-coiled-coil-helix domain containing 4, pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables SUMO transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
     
    involved_in cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of gene expression via chromosomal CpG island methylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein autoubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in heterochromatin ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in pericentric heterochromatin ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase UHRF2
    Names
    ubiquitin-like with PHD and ring finger domains 2, E3 ubiquitin protein ligase
    ubiquitin-like, containing PHD and RING finger domains 2
    NP_001101055.1
    XP_038935936.1
    XP_038935940.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107585.1NP_001101055.1  E3 ubiquitin-protein ligase UHRF2

      See identical proteins and their annotated locations for NP_001101055.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473953
      UniProtKB/TrEMBL
      A6I0X9, D3ZK36
      Related
      ENSRNOP00000015406.4, ENSRNOT00000015406.7
      Conserved Domains (6) summary
      cd01797
      Location:176
      NIRF_N; amino-terminal ubiquitin-like domain of Np95 and NIRF
      smart00213
      Location:374
      UBQ; Ubiquitin homologues
      cd00162
      Location:733776
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cd15617
      Location:347393
      PHD_UHRF2; PHD finger found in ubiquitin-like PHD and RING finger domain-containing protein 2 (UHRF2)
      pfam02182
      Location:447615
      SAD_SRA; SAD/SRA domain
      pfam12148
      Location:126313
      TTD; Tandem tudor domain within UHRF1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      237224050..237291406
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039080012.2XP_038935940.1  E3 ubiquitin-protein ligase UHRF2 isoform X2

      Conserved Domains (4) summary
      cd15617
      Location:347393
      PHD_UHRF2; PHD finger found in ubiquitin-like PHD and RING finger domain-containing protein 2 (UHRF2)
      cd17123
      Location:174
      Ubl_UHRF2; ubiquitin-like (Ubl) domain found in ubiquitin-like PHD and RING finger domain-containing protein 2 (UHRF2)
      pfam02182
      Location:447538
      SAD_SRA; SAD/SRA domain
      pfam12148
      Location:126313
      TTD; Tandem tudor domain within UHRF1
    2. XM_039080008.2XP_038935936.1  E3 ubiquitin-protein ligase UHRF2 isoform X1

      Conserved Domains (5) summary
      COG5222
      Location:478579
      COG5222; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
      cd15617
      Location:123169
      PHD_UHRF2; PHD finger found in ubiquitin-like PHD and RING finger domain-containing protein 2 (UHRF2)
      cd16613
      Location:508553
      RING-HC_UHRF; RING finger, HC subclass, found in ubiquitin-like PHD and RING finger domain-containing proteins, UHRF1 and UHRF2, and similar proteins
      pfam02182
      Location:223391
      SAD_SRA; SAD/SRA domain
      pfam12148
      Location:189
      TTD; Tandem tudor domain within UHRF1

    RNA

    1. XR_005486766.2 RNA Sequence

    2. XR_005486773.2 RNA Sequence

    3. XR_005486776.2 RNA Sequence