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    Sytl2 synaptotagmin-like 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361604, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Sytl2provided by RGD
    Official Full Name
    synaptotagmin-like 2provided by RGD
    Primary source
    RGD:1307647
    See related
    EnsemblRapid:ENSRNOG00000030776 AllianceGenome:RGD:1307647
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable neurexin family protein binding activity; phosphatase binding activity; and phospholipid binding activity. Predicted to be involved in positive regulation of mucus secretion and vesicle docking involved in exocytosis. Predicted to act upstream of or within protein localization to plasma membrane. Predicted to be located in exocytic vesicle; melanosome; and plasma membrane. Orthologous to human SYTL2 (synaptotagmin like 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 140.6), Lung (RPKM 77.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Sytl2 in Genome Data Viewer
    Location:
    1q32
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (153685403..153791758)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (144272870..144379310)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (154536592..154599515) , (156334298..156440327, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol binding clathrin assembly protein Neighboring gene coiled-coil domain containing 83 Neighboring gene uncharacterized LOC134485150 Neighboring gene coiled-coil domain containing 89 Neighboring gene CREB/ATF bZIP transcription factor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Exophilin4/Slp2-a targets glucagon granules to the plasma membrane through unique Ca2+-inhibitory phospholipid-binding activity of the C2A domain. Yu M, et al. Mol Biol Cell, 2007 Feb. PMID 17182843, Free PMC Article
    2. Decreased basal mucus secretion by Slp2-a-deficient gastric surface mucous cells. Saegusa C, et al. Genes Cells, 2006 Jun. PMID 16716193
    3. A newly identified isoform of Slp2a associates with Rab27a in cytotoxic T cells and participates to cytotoxic granule secretion. Ménasché G, et al. Blood, 2008 Dec 15. PMID 18812475
    4. Slp2-a controls renal epithelial cell size through regulation of Rap-ezrin signaling independently of Rab27. Yasuda T, et al. J Cell Sci, 2014 Feb 1. PMID 24284068
    5. Slp1 and Slp2-a localize to the plasma membrane of CTL and contribute to secretion from the immunological synapse. Holt O, et al. Traffic, 2008 Apr. PMID 18266782, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC189337

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables neurexin family protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables neurexin family protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol-4,5-bisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylserine binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in exocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of mucus secretion ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in vesicle docking involved in exocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in exocytic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in exocytic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in melanosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    synaptotagmin-like protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108492.2 → NP_001101962.2  synaptotagmin-like protein 2

      Status: VALIDATED

      Source sequence(s)
      CK842035, JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A8I6AM63
      Related
      ENSRNOP00000096638.1, ENSRNOT00000114461.2
      Conserved Domains (5) summary
      cd04020
      Location:1990 → 2146
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cd08393
      Location:1850 → 1977
      C2A_SLP-1_2; C2 domain first repeat present in Synaptotagmin-like proteins 1 and 2
      PTZ00108
      Location:1592 → 1812
      PTZ00108; DNA topoisomerase 2-like protein; Provisional
      TIGR00600
      Location:197 → 425
      rad2; DNA excision repair protein (rad2)
      cl22851
      Location:5 → 41
      PHD_SF; PHD finger superfamily

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      153685403..153791758
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039082411.2 → XP_038938339.1  synaptotagmin-like protein 2 isoform X4

      Conserved Domains (4) summary
      cd04020
      Location:1934 → 2090
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cd08393
      Location:1794 → 1921
      C2A_SLP-1_2; C2 domain first repeat present in Synaptotagmin-like proteins 1 and 2
      TIGR00600
      Location:197 → 425
      rad2; DNA excision repair protein (rad2)
      cl22851
      Location:5 → 41
      PHD_SF; PHD finger superfamily

    2. XM_039082407.2 → XP_038938335.1  synaptotagmin-like protein 2 isoform X3

      Conserved Domains (4) summary
      cd04020
      Location:1950 → 2106
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cd08393
      Location:1810 → 1937
      C2A_SLP-1_2; C2 domain first repeat present in Synaptotagmin-like proteins 1 and 2
      TIGR00600
      Location:197 → 425
      rad2; DNA excision repair protein (rad2)
      cl22851
      Location:5 → 41
      PHD_SF; PHD finger superfamily

    3. XM_039082402.2 → XP_038938330.1  synaptotagmin-like protein 2 isoform X2

      UniProtKB/TrEMBL
      A0A8I5Y7C8
      Related
      ENSRNOP00000077270.1, ENSRNOT00000103814.2
      Conserved Domains (4) summary
      cd04020
      Location:1974 → 2130
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cd08393
      Location:1834 → 1961
      C2A_SLP-1_2; C2 domain first repeat present in Synaptotagmin-like proteins 1 and 2
      TIGR00600
      Location:197 → 425
      rad2; DNA excision repair protein (rad2)
      cl22851
      Location:5 → 41
      PHD_SF; PHD finger superfamily

    4. XM_008759651.4 → XP_008757873.1  synaptotagmin-like protein 2 isoform X1

      See identical proteins and their annotated locations for XP_008757873.1

      UniProtKB/TrEMBL
      A0A8I6AM63
      Conserved Domains (5) summary
      cd04020
      Location:1990 → 2146
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cd08393
      Location:1850 → 1977
      C2A_SLP-1_2; C2 domain first repeat present in Synaptotagmin-like proteins 1 and 2
      PTZ00108
      Location:1592 → 1812
      PTZ00108; DNA topoisomerase 2-like protein; Provisional
      TIGR00600
      Location:197 → 425
      rad2; DNA excision repair protein (rad2)
      cl22851
      Location:5 → 41
      PHD_SF; PHD finger superfamily

    5. XM_039082420.2 → XP_038938348.1  synaptotagmin-like protein 2 isoform X5

      Conserved Domains (4) summary
      cd04020
      Location:1871 → 2027
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cd08393
      Location:1731 → 1858
      C2A_SLP-1_2; C2 domain first repeat present in Synaptotagmin-like proteins 1 and 2
      TIGR00600
      Location:197 → 425
      rad2; DNA excision repair protein (rad2)
      cl22851
      Location:5 → 41
      PHD_SF; PHD finger superfamily

    6. XM_039082423.2 → XP_038938351.1  synaptotagmin-like protein 2 isoform X6

      Conserved Domains (4) summary
      cd04020
      Location:784 → 940
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cd08393
      Location:644 → 771
      C2A_SLP-1_2; C2 domain first repeat present in Synaptotagmin-like proteins 1 and 2
      TIGR00600
      Location:197 → 547
      rad2; DNA excision repair protein (rad2)
      cl22851
      Location:5 → 41
      PHD_SF; PHD finger superfamily

    7. XM_039082431.2 → XP_038938359.1  synaptotagmin-like protein 2 isoform X8

      Related
      ENSRNOP00000110457.1, ENSRNOT00000137733.1
      Conserved Domains (4) summary
      cd04020
      Location:744 → 900
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cd08393
      Location:604 → 731
      C2A_SLP-1_2; C2 domain first repeat present in Synaptotagmin-like proteins 1 and 2
      TIGR00600
      Location:197 → 547
      rad2; DNA excision repair protein (rad2)
      cl22851
      Location:5 → 41
      PHD_SF; PHD finger superfamily

    8. XM_039082427.2 → XP_038938355.1  synaptotagmin-like protein 2 isoform X7

      Conserved Domains (4) summary
      cd04020
      Location:768 → 924
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cd08393
      Location:628 → 755
      C2A_SLP-1_2; C2 domain first repeat present in Synaptotagmin-like proteins 1 and 2
      TIGR00600
      Location:197 → 572
      rad2; DNA excision repair protein (rad2)
      cl22851
      Location:5 → 41
      PHD_SF; PHD finger superfamily

    9. XM_063267042.1 → XP_063123112.1  synaptotagmin-like protein 2 isoform X8

    10. XM_063267036.1 → XP_063123106.1  synaptotagmin-like protein 2 isoform X7

    11. XM_063267027.1 → XP_063123097.1  synaptotagmin-like protein 2 isoform X6

      Related
      ENSRNOP00000103847.1, ENSRNOT00000153378.1

    12. XM_063267013.1 → XP_063123083.1  synaptotagmin-like protein 2 isoform X3

      Related
      ENSRNOP00000108929.1, ENSRNOT00000163984.1

    13. XM_063266999.1 → XP_063123069.1  synaptotagmin-like protein 2 isoform X2

      UniProtKB/TrEMBL
      A0A8I5Y7C8
    Nucleotide Protein Strain
    Heading Accession and Version

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