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    Skap1 src kinase associated phosphoprotein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 286975, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Skap1provided by RGD
    Official Full Name
    src kinase associated phosphoprotein 1provided by RGD
    Primary source
    RGD:708436
    See related
    EnsemblRapid:ENSRNOG00000023881 AllianceGenome:RGD:708436
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Scap1; Skap55
    Summary
    Enables SH2 domain binding activity. Predicted to be involved in several processes, including positive regulation of cell adhesion; positive regulation of immune response; and positive regulation of integrin activation. Predicted to act upstream of or within positive regulation of cell adhesion and protein localization to plasma membrane. Part of protein-containing complex. Orthologous to human SKAP1 (src kinase associated phosphoprotein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 478.0), Spleen (RPKM 77.5) and 2 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Skap1 in Genome Data Viewer
    Location:
    10q26-q31
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (81921961..82229106)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (81425472..81732651)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (84309379..84619051)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120095284 Neighboring gene uncharacterized LOC120095285 Neighboring gene homeo box B1 Neighboring gene uncharacterized LOC120095286 Neighboring gene uncharacterized LOC102551165 Neighboring gene uncharacterized LOC134480860 Neighboring gene sorting nexin 11

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. SKAP55 coupled with CD45 positively regulates T-cell receptor-mediated gene transcription. Wu L, et al. Mol Cell Biol, 2002 Apr. PMID 11909961, Free PMC Article
    2. Molecular cloning of SKAP55, a novel protein that associates with the protein tyrosine kinase p59fyn in human T-lymphocytes. Marie-Cardine A, et al. J Biol Chem, 1997 Jun 27. PMID 9195899
    3. Signaling Scaffold Protein IQGAP1 Interacts with Microtubule Plus-end Tracking Protein SKAP and Links Dynamic Microtubule Plus-end to Steer Cell Migration. Cao D, et al. J Biol Chem, 2015 Sep 25. PMID 26242911, Free PMC Article
    4. Targeting of MIST to Src-family kinases via SKAP55-SLAP-130 adaptor complex in mast cells. Fujii Y, et al. FEBS Lett, 2003 Apr 10. PMID 12681493
    5. RIAM links the ADAP/SKAP-55 signaling module to Rap1, facilitating T-cell-receptor-mediated integrin activation. Ménasché G, et al. Mol Cell Biol, 2007 Jun. PMID 17403904, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables SH2 domain binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables SH2 domain binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables SH2 domain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein phosphatase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein phosphatase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-containing complex binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in T cell receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in T cell receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in adaptive immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of adaptive immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of adaptive immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of cell adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell-cell adhesion mediated by integrin IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of cell-cell adhesion mediated by integrin ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell-matrix adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of cell-matrix adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of heterotypic cell-cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of heterotypic cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of integrin activation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of integrin activation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of leukocyte cell-cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of leukocyte cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of T cell receptor complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of T cell receptor complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell-cell junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell-cell junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in immunological synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in immunological synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane raft IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane raft ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    src kinase-associated phosphoprotein 1
    Names
    SKAP-55
    SKAP55 adapter protein
    SKAP55 adaptor protein
    pp55
    src family-associated phosphoprotein 1
    src kinase-associated phosphoprotein of 55 kDa

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_173311.2 → NP_775433.2  src kinase-associated phosphoprotein 1

      See identical proteins and their annotated locations for NP_775433.2

      Status: PROVISIONAL

      Source sequence(s)
      BC097931
      UniProtKB/Swiss-Prot
      Q4V7G1, Q8CHI6
      UniProtKB/TrEMBL
      A0A8I5Y073, A6HIF5
      Related
      ENSRNOP00000033594.4, ENSRNOT00000030159.6
      Conserved Domains (3) summary
      cd12044
      Location:293 → 345
      SH3_SKAP1; Src Homology 3 domain of Src Kinase-Associated Phosphoprotein 1
      cd13380
      Location:108 → 213
      PH_Skap1; Src kinase-associated phosphoprotein 1 Pleckstrin homology (PH) domain
      pfam00169
      Location:108 → 210
      PH; PH domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      81921961..82229106
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017597053.3 → XP_017452542.1  src kinase-associated phosphoprotein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I5Y073, A0A8I5ZTK3
      Related
      ENSRNOP00000080687.1, ENSRNOT00000095547.2

    2. XM_039085325.2 → XP_038941253.1  src kinase-associated phosphoprotein 1 isoform X2

      Conserved Domains (2) summary
      cd12044
      Location:130 → 182
      SH3_SKAP1; Src Homology 3 domain of Src Kinase-Associated Phosphoprotein 1
      cl17171
      Location:1 → 50
      PH-like; Pleckstrin homology-like domain

    3. XM_039085324.2 → XP_038941252.1  src kinase-associated phosphoprotein 1 isoform X2

      Conserved Domains (2) summary
      cd12044
      Location:130 → 182
      SH3_SKAP1; Src Homology 3 domain of Src Kinase-Associated Phosphoprotein 1
      cl17171
      Location:1 → 50
      PH-like; Pleckstrin homology-like domain

    4. XM_039085326.2 → XP_038941254.1  src kinase-associated phosphoprotein 1 isoform X2

      Conserved Domains (2) summary
      cd12044
      Location:130 → 182
      SH3_SKAP1; Src Homology 3 domain of Src Kinase-Associated Phosphoprotein 1
      cl17171
      Location:1 → 50
      PH-like; Pleckstrin homology-like domain

    5. XM_063268504.1 → XP_063124574.1  src kinase-associated phosphoprotein 1 isoform X2

    6. XM_039085327.2 → XP_038941255.1  src kinase-associated phosphoprotein 1 isoform X2

      Conserved Domains (2) summary
      cd12044
      Location:130 → 182
      SH3_SKAP1; Src Homology 3 domain of Src Kinase-Associated Phosphoprotein 1
      cl17171
      Location:1 → 50
      PH-like; Pleckstrin homology-like domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4V7G1.1 GenPept UniProtKB/Swiss-Prot:Q4V7G1

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