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    Senp5 SUMO specific peptidase 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 103689978, updated on 9-Dec-2024

    Summary

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    Symbol
    Senp5provided by RGD
    Full Name
    SUMO specific peptidase 5provided by RGD
    Primary source
    RGD:1304604
    See related
    EnsemblRapid:ENSRNOG00000064973 AllianceGenome:RGD:1304604
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable SUMO-specific endopeptidase activity and deSUMOylase activity. Predicted to be involved in protein desumoylation. Predicted to be located in nucleolus. Predicted to be active in nucleus; postsynaptic cytosol; and presynaptic cytosol. Orthologous to human SENP5 (SUMO specific peptidase 5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 125.1), Spleen (RPKM 104.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Senp5 in Genome Data Viewer
    Location:
    11q22
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (82289680..82324545)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (68784699..68819569)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (72035540..72070679)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene centrosomal protein 19 Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class X Neighboring gene small nucleolar RNA SNORA17 Neighboring gene p21 (RAC1) activated kinase 2 Neighboring gene nuclear cap binding protein subunit 2 Neighboring gene NCBP2 antisense 2 (head to head)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. SENP5 deteriorates traumatic brain injury via SUMO2-dependent suppression of E2F1 SUMOylation. Ding Y, et al. Acta Biochim Biophys Sin (Shanghai), 2023 Jul 5. PMID 37403456, Free PMC Article
    2. Small ubiquitin-related modifier (SUMO)-specific proteases: profiling the specificities and activities of human SENPs. Mikolajczyk J, et al. J Biol Chem, 2007 Sep 7. PMID 17591783
    3. Characterization of a family of nucleolar SUMO-specific proteases with preference for SUMO-2 or SUMO-3. Gong L, et al. J Biol Chem, 2006 Jun 9. PMID 16608850
    4. Gene and alternative splicing annotation with AIR. Florea L, et al. Genome Res, 2005 Jan. PMID 15632090, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SENP5 deteriorates traumatic brain injury via SUMO2-dependent suppression of E2F1 SUMOylation.
      Title: SENP5 deteriorates traumatic brain injury via SUMO2-dependent suppression of E2F1 SUMOylation.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables SUMO-specific endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables deSUMOylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein desumoylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in postsynaptic cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in presynaptic cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    sentrin-specific protease 5
    Names
    SUMO/sentrin specific protease 5
    SUMO1/sentrin specific peptidase 5
    Sumo1/sentrin/SMT3 specific peptidase 5
    NP_001389087.1
    NP_001389088.1
    XP_008767002.2
    XP_038944857.1
    XP_063126300.1
    XP_063126301.1
    XP_063126302.1
    XP_063126303.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001402158.1 → NP_001389087.1  sentrin-specific protease 5 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000011
      UniProtKB/TrEMBL
      A6IRU7, D4A2S8
      Related
      ENSRNOP00000081117.1, ENSRNOT00000103713.2

    2. NM_001402159.1 → NP_001389088.1  sentrin-specific protease 5 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000011

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      82289680..82324545
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063270233.1 → XP_063126303.1  sentrin-specific protease 5 isoform X4

    2. XM_039088929.2 → XP_038944857.1  sentrin-specific protease 5 isoform X5

      Conserved Domains (1) summary
      COG5160
      Location:218 → 399
      ULP1; Protease, Ulp1 family [Posttranslational modification, protein turnover, chaperones]

    3. XM_063270231.1 → XP_063126301.1  sentrin-specific protease 5 isoform X1

      UniProtKB/TrEMBL
      A6IRU7

    4. XM_063270230.1 → XP_063126300.1  sentrin-specific protease 5 isoform X1

      UniProtKB/TrEMBL
      A6IRU7

    5. XM_008768780.4 → XP_008767002.2  sentrin-specific protease 5 isoform X2

      UniProtKB/TrEMBL
      A6IRU7, D4A2S8
      Conserved Domains (2) summary
      pfam02902
      Location:576 → 748
      Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain
      pfam08766
      Location:489 → 546
      DEK_C; DEK C terminal domain

    6. XM_063270232.1 → XP_063126302.1  sentrin-specific protease 5 isoform X3

      UniProtKB/TrEMBL
      A0A8I6AQ37
    Nucleotide Protein Strain
    Heading Accession and Version

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