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Dlg1 discs large MAGUK scaffold protein 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 25252, updated on 9-Dec-2024

Summary

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Official Symbol: Dlg1provided by RGD
Official Full Name: discs large MAGUK scaffold protein 1provided by RGD
Primary source: RGD:2505
See related: EnsemblRapid:ENSRNOG00000038597 AllianceGenome:RGD:2505
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Dlgh1; SAP97
Summary: Enables several functions, including PDZ domain binding activity; ionotropic glutamate receptor binding activity; and kinesin binding activity. Involved in several processes, including cellular response to brain-derived neurotrophic factor stimulus; neurotransmitter receptor localization to postsynaptic specialization membrane; and positive regulation of potassium ion transport. Located in several cellular components, including basolateral plasma membrane; lateral plasma membrane; and paranode region of axon. Is active in glutamatergic synapse and postsynaptic density, intracellular component. Biomarker of Parkinson's disease. Human ortholog(s) of this gene implicated in invasive ductal carcinoma. Orthologous to human DLG1 (discs large MAGUK scaffold protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 214.1), Lung (RPKM 143.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

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See Dlg1 in Genome Data Viewer

Location:: 11q22

Exon count:: 30

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	11	NC_086029.1 (82416853..82607797, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	11	NC_051346.1 (68911883..69103230, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	11	NC_005110.4 (72164566..72378895, complement)

Chromosome 11 - NC_086029.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Spinal nerve transection-induced upregulation of SAP97 via promoting membrane trafficking of GluA1-containing AMPA receptors in the dorsal horn contributes to the pathogenesis of neuropathic pain.
Title: Spinal nerve transection-induced upregulation of SAP97 via promoting membrane trafficking of GluA1-containing AMPA receptors in the dorsal horn contributes to the pathogenesis of neuropathic pain.
The SF3B1(R625H) mutation promotes prolactinoma tumor progression through aberrant splicing of DLG1.
Title: The SF3B1(R625H) mutation promotes prolactinoma tumor progression through aberrant splicing of DLG1.
Schizophrenia-associated SAP97 mutations increase glutamatergic synapse strength in the dentate gyrus and impair contextual episodic memory in rats.
Title: Schizophrenia-associated SAP97 mutations increase glutamatergic synapse strength in the dentate gyrus and impair contextual episodic memory in rats.
This study reveals plasticity in surface NMDAR localization driven by mutant HTT and identifies the similar but independent roles of SAP97 N-terminal isoforms in maintaining normal synaptic function in pathological states.
Title: SAP97-mediated rescue of NMDA receptor surface distribution in a neuronal model of Huntington's disease.
Results indicate that the GluA1 subunit accessory protein SAP97 may represent a novel target for pharmacotherapeutic intervention in the treatment of cocaine craving
Title: A Critical Role for the GluA1 Accessory Protein, SAP97, in Cocaine Seeking.
dendrite branching promoting action of full length SAP97 depends on ligand(s) that bind to the PDZ3 domain.
Title: Structure-function analysis of SAP97, a modular scaffolding protein that drives dendrite growth.
The data establish a prominent role for PDZ2 and I3 domains of SAP97 in organizing the ss1-adrenergic receptosome involved in connecting the ss1-AR to trafficking and signaling networks.
Title: SAP97 controls the trafficking and resensitization of the beta-1-adrenergic receptor through its PDZ2 and I3 domains.
Acute BDNF treatment upregulates the interactions between AMPA receptor subunits (GluR1 and GluR2) with their scaffold proteins SAP97 and GRIP1, respectively.
Title: Acute BDNF treatment upregulates GluR1-SAP97 and GluR2-GRIP1 interactions: implications for sustained AMPA receptor expression.
studies show that SAP97 interactions with CRFR1 attenuate CRFR1 endocytosis and that SAP97 is involved in coupling G protein-coupled receptors to the activation of the ERK1/2 signaling pathway.
Title: Role of SAP97 protein in the regulation of corticotropin-releasing factor receptor 1 endocytosis and extracellular signal-regulated kinase 1/2 signaling.
Scribble/Lgl/Dlg polarity protein complex is a regulator of blood-testis barrier dynamics and spermatid polarity during spermatogenesis
Title: The Scribble/Lgl/Dlg polarity protein complex is a regulator of blood-testis barrier dynamics and spermatid polarity during spermatogenesis.

Submit: New GeneRIF Correction See all GeneRIFs (39)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AU049047 (e-PCR)
- UniSTS:145495

AW530915 (e-PCR)
- UniSTS:244574

BE109290 (e-PCR)
- UniSTS:248227

RH138276 (e-PCR)
- UniSTS:220363

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables L27 domain binding	IEA Inferred from Electronic Annotation more info
enables L27 domain binding	ISO Inferred from Sequence Orthology more info
enables PDZ domain binding	IPI Inferred from Physical Interaction more info	PubMed
enables ionotropic glutamate receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables ionotropic glutamate receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables kinase binding	IEA Inferred from Electronic Annotation more info
enables kinase binding	ISO Inferred from Sequence Orthology more info
enables kinesin binding	IPI Inferred from Physical Interaction more info	PubMed
enables molecular adaptor activity	IEA Inferred from Electronic Annotation more info
enables molecular adaptor activity	ISO Inferred from Sequence Orthology more info
enables phosphatase binding	IEA Inferred from Electronic Annotation more info
enables phosphatase binding	ISO Inferred from Sequence Orthology more info
enables phosphatase binding	ISS Inferred from Sequence or Structural Similarity more info
enables potassium channel regulator activity	IEA Inferred from Electronic Annotation more info
enables potassium channel regulator activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables structural constituent of postsynaptic density	IEA Inferred from Electronic Annotation more info
enables structural constituent of postsynaptic density	ISO Inferred from Sequence Orthology more info
enables transmembrane transporter binding	IEA Inferred from Electronic Annotation more info
enables transmembrane transporter binding	IPI Inferred from Physical Interaction more info	PubMed
enables transmembrane transporter binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within T cell activation	ISO Inferred from Sequence Orthology more info
involved_in T cell proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in actin filament organization	ISO Inferred from Sequence Orthology more info
involved_in actin filament organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in actin filament polymerization	IEA Inferred from Electronic Annotation more info
acts_upstream_of actin filament polymerization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within activation of protein kinase activity	ISO Inferred from Sequence Orthology more info
involved_in amyloid precursor protein metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within amyloid precursor protein metabolic process	ISO Inferred from Sequence Orthology more info
involved_in astral microtubule organization	IEA Inferred from Electronic Annotation more info
involved_in astral microtubule organization	ISO Inferred from Sequence Orthology more info
involved_in bicellular tight junction assembly	IEA Inferred from Electronic Annotation more info
involved_in bicellular tight junction assembly	ISO Inferred from Sequence Orthology more info
involved_in branching involved in ureteric bud morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within branching involved in ureteric bud morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in cell adhesion	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in cell-cell adhesion	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to brain-derived neurotrophic factor stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in cerebral cortex development	IEP Inferred from Expression Pattern more info	PubMed
involved_in chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in chemical synaptic transmission	IEA Inferred from Electronic Annotation more info
involved_in cortical actin cytoskeleton organization	IEA Inferred from Electronic Annotation more info
involved_in cortical actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in cortical actin cytoskeleton organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in cortical microtubule organization	IEA Inferred from Electronic Annotation more info
involved_in cortical microtubule organization	ISO Inferred from Sequence Orthology more info
involved_in embryonic skeletal system morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within embryonic skeletal system morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in endothelial cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in endothelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in endothelial cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in epithelial structure maintenance	ISO Inferred from Sequence Orthology more info
involved_in epithelial structure maintenance	ISS Inferred from Sequence or Structural Similarity more info
involved_in establishment of centrosome localization	IEA Inferred from Electronic Annotation more info
involved_in establishment of centrosome localization	ISO Inferred from Sequence Orthology more info
involved_in establishment or maintenance of epithelial cell apical/basal polarity	IBA Inferred from Biological aspect of Ancestor more info
involved_in hard palate development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within hard palate development	ISO Inferred from Sequence Orthology more info
involved_in immunological synapse formation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within immunological synapse formation	ISO Inferred from Sequence Orthology more info
involved_in lens development in camera-type eye	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lens development in camera-type eye	ISO Inferred from Sequence Orthology more info
involved_in maintenance of postsynaptic density structure	IEA Inferred from Electronic Annotation more info
involved_in membrane raft organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within membrane raft organization	ISO Inferred from Sequence Orthology more info
involved_in membrane repolarization during ventricular cardiac muscle cell action potential	IEA Inferred from Electronic Annotation more info
involved_in membrane repolarization during ventricular cardiac muscle cell action potential	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of ERK1 and ERK2 cascade	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of G1/S transition of mitotic cell cycle	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of G1/S transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of G1/S transition of mitotic cell cycle	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of T cell proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of epithelial cell proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of p38MAPK cascade	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of p38MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in nervous system development	IBA Inferred from Biological aspect of Ancestor more info
involved_in neurotransmitter receptor localization to postsynaptic specialization membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in neurotransmitter receptor localization to postsynaptic specialization membrane	IEA Inferred from Electronic Annotation more info
involved_in neurotransmitter receptor localization to postsynaptic specialization membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neurotransmitter receptor localization to postsynaptic specialization membrane	ISO Inferred from Sequence Orthology more info
involved_in peristalsis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within peristalsis	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of actin filament polymerization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of actin filament polymerization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of potassium ion transport	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of potassium ion transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of potassium ion transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein localization to plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein localization	ISO Inferred from Sequence Orthology more info
involved_in protein localization to plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in protein localization to synapse	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein-containing complex localization	ISO Inferred from Sequence Orthology more info
involved_in receptor clustering	IBA Inferred from Biological aspect of Ancestor more info
involved_in receptor localization to synapse	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell shape	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell shape	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of membrane potential	ISO Inferred from Sequence Orthology more info
involved_in regulation of membrane potential	ISO Inferred from Sequence Orthology more info
involved_in regulation of myelination	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of myelination	ISO Inferred from Sequence Orthology more info
NOT involved_in regulation of non-canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in regulation of postsynaptic membrane neurotransmitter receptor levels	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of potassium ion export across plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in regulation of potassium ion export across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in regulation of potassium ion import	IEA Inferred from Electronic Annotation more info
involved_in regulation of potassium ion import	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of protein localization to synapse	IEA Inferred from Electronic Annotation more info
involved_in regulation of protein localization to synapse	ISO Inferred from Sequence Orthology more info
involved_in regulation of ventricular cardiac muscle cell action potential	IEA Inferred from Electronic Annotation more info
involved_in regulation of ventricular cardiac muscle cell action potential	ISO Inferred from Sequence Orthology more info
involved_in reproductive structure development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within reproductive structure development	ISO Inferred from Sequence Orthology more info
involved_in smooth muscle tissue development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within smooth muscle tissue development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within tissue morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within ureteric bud development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
part_of MPP7-DLG1-LIN7 complex	IEA Inferred from Electronic Annotation more info
part_of MPP7-DLG1-LIN7 complex	ISO Inferred from Sequence Orthology more info
located_in T-tubule	IDA Inferred from Direct Assay more info	PubMed
located_in anchoring junction	IEA Inferred from Electronic Annotation more info
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in basal plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in basement membrane	IEA Inferred from Electronic Annotation more info
located_in basement membrane	ISO Inferred from Sequence Orthology more info
is_active_in basolateral plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in basolateral plasma membrane	IEA Inferred from Electronic Annotation more info
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in basolateral plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in bicellular tight junction	IEA Inferred from Electronic Annotation more info
located_in bicellular tight junction	ISO Inferred from Sequence Orthology more info
located_in cell junction	ISO Inferred from Sequence Orthology more info
located_in cell projection membrane	IEA Inferred from Electronic Annotation more info
located_in cell projection membrane	ISO Inferred from Sequence Orthology more info
located_in cell-cell junction	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic side of plasma membrane	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	TAS Traceable Author Statement more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in immunological synapse	IEA Inferred from Electronic Annotation more info
located_in immunological synapse	ISO Inferred from Sequence Orthology more info
located_in lateral loop	IEA Inferred from Electronic Annotation more info
located_in lateral loop	ISO Inferred from Sequence Orthology more info
located_in lateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in lateral plasma membrane	IEA Inferred from Electronic Annotation more info
located_in lateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane raft	IEA Inferred from Electronic Annotation more info
located_in membrane raft	ISO Inferred from Sequence Orthology more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
located_in microtubule	ISO Inferred from Sequence Orthology more info
located_in microvillus	IDA Inferred from Direct Assay more info	PubMed
located_in myelin sheath abaxonal region	IEA Inferred from Electronic Annotation more info
located_in myelin sheath abaxonal region	ISO Inferred from Sequence Orthology more info
is_active_in neuromuscular junction	IBA Inferred from Biological aspect of Ancestor more info
located_in neuromuscular junction	IEA Inferred from Electronic Annotation more info
located_in neuromuscular junction	ISO Inferred from Sequence Orthology more info
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
located_in neuron projection	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in node of Ranvier	IEA Inferred from Electronic Annotation more info
located_in node of Ranvier	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in paranode region of axon	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	TAS Traceable Author Statement more info
located_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic density	IEA Inferred from Electronic Annotation more info
located_in postsynaptic density	ISO Inferred from Sequence Orthology more info
located_in postsynaptic density	TAS Traceable Author Statement more info	PubMed
is_active_in postsynaptic density membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in postsynaptic density, intracellular component	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic membrane	TAS Traceable Author Statement more info	PubMed
located_in presynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
located_in synapse	ISO Inferred from Sequence Orthology more info
located_in synaptic membrane	IEA Inferred from Electronic Annotation more info
located_in synaptic membrane	ISO Inferred from Sequence Orthology more info
located_in synaptic vesicle membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: disks large homolog 1

Names: Drosophila discs-large tumor suppressor homologue (synapse associated protein); discs large homolog 1, scribble cell polarity complex component; discs, large homolog 1; synapse-associated protein 97

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001393734.1 → NP_001380663.1 disks large homolog 1 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000011

UniProtKB/TrEMBL

A0A8I6A5M7, A6IRV5

Related

ENSRNOP00000088710.1, ENSRNOT00000102386.2

Conserved Domains (7) summary

cd12031
Location:549 → 615

SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1

smart00228
Location:430 → 514

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:191 → 275

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00625
Location:703 → 881

Guanylate_kin; Guanylate kinase

pfam09058
Location:2 → 62

L27_1

pfam10600
Location:371 → 432

PDZ_assoc; PDZ-associated domain of NMDA receptors

pfam10608
Location:106 → 190

MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
NM_012788.2 → NP_036920.2 disks large homolog 1 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000011

UniProtKB/Swiss-Prot

Q62696

UniProtKB/TrEMBL

A6IRV7

Conserved Domains (7) summary

cd12031
Location:582 → 648

SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1

smart00228
Location:463 → 547

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:224 → 308

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00625
Location:721 → 899

Guanylate_kin; Guanylate kinase

pfam09058
Location:2 → 62

L27_1

pfam10600
Location:404 → 465

PDZ_assoc; PDZ-associated domain of NMDA receptors

pfam10608
Location:106 → 223

MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086029.1 Reference GRCr8

Range

82416853..82607797 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063270299.1 → XP_063126369.1 disks large homolog 1 isoform X14

UniProtKB/TrEMBL

A6IRV5
XM_063270300.1 → XP_063126370.1 disks large homolog 1 isoform X15

UniProtKB/Swiss-Prot

Q62696

UniProtKB/TrEMBL

A6IRV6

Related

ENSRNOP00000091905.1, ENSRNOT00000117728.2
XM_039088017.2 → XP_038943945.1 disks large homolog 1 isoform X13

UniProtKB/Swiss-Prot

Q62696

Conserved Domains (7) summary

cd12031
Location:582 → 648

SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1

smart00228
Location:463 → 547

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:224 → 308

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00625
Location:748 → 926

Guanylate_kin; Guanylate kinase

pfam09058
Location:2 → 62

L27_1

pfam10600
Location:404 → 465

PDZ_assoc; PDZ-associated domain of NMDA receptors

pfam10608
Location:106 → 223

MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
XM_039088016.2 → XP_038943944.1 disks large homolog 1 isoform X12

UniProtKB/Swiss-Prot

Q62696

Conserved Domains (7) summary

cd12031
Location:549 → 615

SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1

smart00228
Location:430 → 514

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:191 → 275

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00625
Location:681 → 859

Guanylate_kin; Guanylate kinase

pfam09058
Location:2 → 62

L27_1

pfam10600
Location:371 → 432

PDZ_assoc; PDZ-associated domain of NMDA receptors

pfam10608
Location:106 → 190

MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
XM_039088015.2 → XP_038943943.1 disks large homolog 1 isoform X11

UniProtKB/Swiss-Prot

Q62696

Conserved Domains (7) summary

cd12031
Location:549 → 615

SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1

smart00228
Location:430 → 514

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:191 → 275

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00625
Location:688 → 866

Guanylate_kin; Guanylate kinase

pfam09058
Location:2 → 62

L27_1

pfam10600
Location:371 → 432

PDZ_assoc; PDZ-associated domain of NMDA receptors

pfam10608
Location:106 → 190

MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
XM_039088014.2 → XP_038943942.1 disks large homolog 1 isoform X10

UniProtKB/Swiss-Prot

Q62696

Conserved Domains (7) summary

cd12031
Location:549 → 615

SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1

smart00228
Location:430 → 514

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:191 → 275

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00625
Location:693 → 871

Guanylate_kin; Guanylate kinase

pfam09058
Location:2 → 62

L27_1

pfam10600
Location:371 → 432

PDZ_assoc; PDZ-associated domain of NMDA receptors

pfam10608
Location:106 → 190

MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
XM_039088013.2 → XP_038943941.1 disks large homolog 1 isoform X9

UniProtKB/TrEMBL

A6IRV5

Conserved Domains (7) summary

cd12031
Location:549 → 615

SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1

smart00228
Location:430 → 514

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:191 → 275

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00625
Location:702 → 880

Guanylate_kin; Guanylate kinase

pfam09058
Location:2 → 62

L27_1

pfam10600
Location:371 → 432

PDZ_assoc; PDZ-associated domain of NMDA receptors

pfam10608
Location:106 → 190

MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
XM_063270298.1 → XP_063126368.1 disks large homolog 1 isoform X8

UniProtKB/Swiss-Prot

Q62696
XM_039088008.2 → XP_038943936.1 disks large homolog 1 isoform X7

UniProtKB/Swiss-Prot

Q62696

Conserved Domains (7) summary

cd12031
Location:567 → 633

SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1

smart00228
Location:448 → 532

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:224 → 308

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00625
Location:721 → 899

Guanylate_kin; Guanylate kinase

pfam09058
Location:2 → 62

L27_1

pfam10600
Location:406 → 450

PDZ_assoc; PDZ-associated domain of NMDA receptors

pfam10608
Location:106 → 223

MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
XM_039088006.2 → XP_038943934.1 disks large homolog 1 isoform X5

UniProtKB/Swiss-Prot

Q62696

Conserved Domains (7) summary

cd12031
Location:567 → 633

SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1

smart00228
Location:448 → 532

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:224 → 308

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00625
Location:733 → 911

Guanylate_kin; Guanylate kinase

pfam09058
Location:2 → 62

L27_1

pfam10600
Location:406 → 450

PDZ_assoc; PDZ-associated domain of NMDA receptors

pfam10608
Location:106 → 223

MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
XM_039088007.2 → XP_038943935.1 disks large homolog 1 isoform X6

UniProtKB/Swiss-Prot

Q62696

Related

ENSRNOP00000081862.2, ENSRNOT00000113230.2

Conserved Domains (7) summary

cd12031
Location:582 → 648

SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1

smart00228
Location:463 → 547

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:224 → 308

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00625
Location:726 → 904

Guanylate_kin; Guanylate kinase

pfam09058
Location:2 → 62

L27_1

pfam10600
Location:404 → 465

PDZ_assoc; PDZ-associated domain of NMDA receptors

pfam10608
Location:106 → 223

MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
XM_039088005.2 → XP_038943933.1 disks large homolog 1 isoform X4

UniProtKB/Swiss-Prot

Q62696

UniProtKB/TrEMBL

A6IRV8

Conserved Domains (7) summary

cd12031
Location:582 → 648

SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1

smart00228
Location:463 → 547

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:224 → 308

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00625
Location:735 → 913

Guanylate_kin; Guanylate kinase

pfam09058
Location:2 → 62

L27_1

pfam10600
Location:404 → 465

PDZ_assoc; PDZ-associated domain of NMDA receptors

pfam10608
Location:106 → 223

MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
XM_039088002.2 → XP_038943930.1 disks large homolog 1 isoform X1

UniProtKB/Swiss-Prot

Q62696

Conserved Domains (7) summary

cd12031
Location:582 → 648

SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1

smart00228
Location:463 → 547

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:224 → 308

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00625
Location:747 → 925

Guanylate_kin; Guanylate kinase

pfam09058
Location:2 → 62

L27_1

pfam10600
Location:404 → 465

PDZ_assoc; PDZ-associated domain of NMDA receptors

pfam10608
Location:106 → 223

MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
XM_039088004.2 → XP_038943932.1 disks large homolog 1 isoform X3

UniProtKB/Swiss-Prot

Q62696

UniProtKB/TrEMBL

A0A0G2K1M2

Related

ENSRNOP00000071898.2, ENSRNOT00000078737.3

Conserved Domains (7) summary

cd12031
Location:582 → 648

SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1

smart00228
Location:463 → 547

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:224 → 308

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00625
Location:736 → 914

Guanylate_kin; Guanylate kinase

pfam09058
Location:2 → 62

L27_1

pfam10600
Location:404 → 465

PDZ_assoc; PDZ-associated domain of NMDA receptors

pfam10608
Location:106 → 223

MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
XM_039088003.2 → XP_038943931.1 disks large homolog 1 isoform X2

UniProtKB/Swiss-Prot

Q62696

Conserved Domains (7) summary

cd12031
Location:582 → 648

SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1

smart00228
Location:463 → 547

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:224 → 308

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00625
Location:743 → 921

Guanylate_kin; Guanylate kinase

pfam09058
Location:2 → 62

L27_1

pfam10600
Location:404 → 465

PDZ_assoc; PDZ-associated domain of NMDA receptors

pfam10608
Location:106 → 223

MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
XM_039088020.2 → XP_038943948.1 disks large homolog 1 isoform X17

UniProtKB/Swiss-Prot

Q62696

Conserved Domains (6) summary

cd12031
Location:486 → 552

SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1

smart00228
Location:367 → 451

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:128 → 212

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00625
Location:652 → 830

Guanylate_kin; Guanylate kinase

pfam10600
Location:308 → 369

PDZ_assoc; PDZ-associated domain of NMDA receptors

pfam10608
Location:10 → 127

MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
XM_063270303.1 → XP_063126373.1 disks large homolog 1 isoform X25

UniProtKB/TrEMBL

A0A8I6A0H6
XM_063270302.1 → XP_063126372.1 disks large homolog 1 isoform X24

UniProtKB/TrEMBL

A0A8I6A0H6
XM_039088025.2 → XP_038943953.1 disks large homolog 1 isoform X23

UniProtKB/TrEMBL

A0A8I6A0H6

Conserved Domains (6) summary

cd12031
Location:466 → 532

SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1

smart00228
Location:347 → 431

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:108 → 192

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00625
Location:598 → 776

Guanylate_kin; Guanylate kinase

pfam10600
Location:288 → 349

PDZ_assoc; PDZ-associated domain of NMDA receptors

pfam10608
Location:29 → 107

MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
XM_039088024.2 → XP_038943952.1 disks large homolog 1 isoform X22

UniProtKB/TrEMBL

A0A8I5ZVT1, A0A8I6A0H6

Conserved Domains (6) summary

cd12031
Location:466 → 532

SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1

smart00228
Location:347 → 431

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:108 → 192

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00625
Location:610 → 788

Guanylate_kin; Guanylate kinase

pfam10600
Location:288 → 349

PDZ_assoc; PDZ-associated domain of NMDA receptors

pfam10608
Location:29 → 107

MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
XM_039088022.2 → XP_038943950.1 disks large homolog 1 isoform X19

UniProtKB/TrEMBL

A0A8I6A0H6

Related

ENSRNOP00000085582.1, ENSRNOT00000109975.2

Conserved Domains (6) summary

cd12031
Location:466 → 532

SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1

smart00228
Location:347 → 431

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:108 → 192

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00625
Location:632 → 810

Guanylate_kin; Guanylate kinase

pfam10600
Location:288 → 349

PDZ_assoc; PDZ-associated domain of NMDA receptors

pfam10608
Location:29 → 107

MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
XM_063270301.1 → XP_063126371.1 disks large homolog 1 isoform X21

UniProtKB/TrEMBL

A0A8I6A0H6
XM_039088023.2 → XP_038943951.1 disks large homolog 1 isoform X20

UniProtKB/TrEMBL

A0A8I6A0H6

Conserved Domains (7) summary

cd12031
Location:499 → 565

SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1

smart00228
Location:380 → 464

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

COG3087
Location:30 → 130

FtsN; Cell division protein FtsN [Cell cycle control, cell division, chromosome partitioning]

cd00992
Location:141 → 225

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00625
Location:631 → 809

Guanylate_kin; Guanylate kinase

pfam10600
Location:321 → 382

PDZ_assoc; PDZ-associated domain of NMDA receptors

pfam10608
Location:98 → 140

MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
XM_039088021.2 → XP_038943949.1 disks large homolog 1 isoform X18

UniProtKB/TrEMBL

A0A8I6A0H6, A0A8I6GMS2

Related

ENSRNOP00000097997.1, ENSRNOT00000108927.2

Conserved Domains (7) summary

cd12031
Location:499 → 565

SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1

smart00228
Location:380 → 464

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

COG3087
Location:30 → 130

FtsN; Cell division protein FtsN [Cell cycle control, cell division, chromosome partitioning]

cd00992
Location:141 → 225

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00625
Location:643 → 821

Guanylate_kin; Guanylate kinase

pfam10600
Location:321 → 382

PDZ_assoc; PDZ-associated domain of NMDA receptors

pfam10608
Location:98 → 140

MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
XM_039088019.2 → XP_038943947.1 disks large homolog 1 isoform X16

UniProtKB/TrEMBL

A0A8I6A0H6

Conserved Domains (7) summary

cd12031
Location:499 → 565

SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1

smart00228
Location:380 → 464

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

COG3087
Location:30 → 130

FtsN; Cell division protein FtsN [Cell cycle control, cell division, chromosome partitioning]

cd00992
Location:141 → 225

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00625
Location:665 → 843

Guanylate_kin; Guanylate kinase

pfam10600
Location:321 → 382

PDZ_assoc; PDZ-associated domain of NMDA receptors

pfam10608
Location:98 → 140

MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK