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    Kntc1 kinetochore associated 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 304477, updated on 9-Dec-2024

    Summary

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    Symbol
    Kntc1provided by RGD
    Full Name
    kinetochore associated 1provided by RGD
    Primary source
    RGD:1307905
    See related
    EnsemblRapid:ENSRNOG00000033658 AllianceGenome:RGD:1307905
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable small GTPase binding activity. Predicted to be involved in mitotic sister chromatid segregation; mitotic spindle assembly checkpoint signaling; and protein localization to kinetochore involved in kinetochore assembly. Predicted to be located in cytoskeleton; cytosol; and plasma membrane. Predicted to be part of RZZ complex. Predicted to be active in cytoplasm and kinetochore microtubule. Orthologous to human KNTC1 (kinetochore associated 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 82.4), Spleen (RPKM 52.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Kntc1 in Genome Data Viewer
    Location:
    12q15-q16
    Exon count:
    65
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (38429925..38500564, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (32769020..32839617, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (38200463..38274162, complement)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene hydroxycarboxylic acid receptor 1 Neighboring gene hydroxycarboxylic acid receptor 2 Neighboring gene arginine and serine rich coiled-coil 2 Neighboring gene zinc finger CCHC-type containing 8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Human Zw10 and ROD are mitotic checkpoint proteins that bind to kinetochores. Chan GK, et al. Nat Cell Biol, 2000 Dec. PMID 11146660
    2. Structural analysis of the RZZ complex reveals common ancestry with multisubunit vesicle tethering machinery. Civril F, et al. Structure, 2010 May 12. PMID 20462495
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables small GTPase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitotic sister chromatid segregation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic spindle assembly checkpoint signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic spindle assembly checkpoint signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to kinetochore involved in kinetochore assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of RZZ complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of RZZ complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in actin cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in kinetochore microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in kinetochore microtubule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in spindle pole ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    kinetochore-associated protein 1
    Names
    kinetochore-associated protein 1-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107140.1 → NP_001100610.1  kinetochore-associated protein 1

      See identical proteins and their annotated locations for NP_001100610.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473973
      UniProtKB/TrEMBL
      A6J131, D3ZVJ3
      Related
      ENSRNOP00000063431.2, ENSRNOT00000063990.5
      Conserved Domains (1) summary
      pfam10493
      Location:1427 → 1970
      Rod_C; Rough deal protein C-terminal region

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      38429925..38500564 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008769228.4 → XP_008767450.1  kinetochore-associated protein 1 isoform X1

      See identical proteins and their annotated locations for XP_008767450.1

      UniProtKB/TrEMBL
      A0A8I6G9X6
      Related
      ENSRNOP00000084132.1, ENSRNOT00000103129.2
      Conserved Domains (1) summary
      pfam10493
      Location:1582 → 2125
      Rod_C; Rough deal protein C-terminal region

    2. XM_063271315.1 → XP_063127385.1  kinetochore-associated protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6G9X6

    3. XM_039089456.2 → XP_038945384.1  kinetochore-associated protein 1 isoform X2

      Conserved Domains (1) summary
      pfam10493
      Location:1430 → 1974
      Rod_C; Rough deal protein C-terminal region
    Nucleotide Protein Strain
    Heading Accession and Version

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