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    Vrk2 VRK serine/threonine kinase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360991, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Vrk2provided by RGD
    Official Full Name
    VRK serine/threonine kinase 2provided by RGD
    Primary source
    RGD:1311585
    See related
    EnsemblRapid:ENSRNOG00000007864 AllianceGenome:RGD:1311585
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable protein domain specific binding activity; protein kinase binding activity; and protein serine/threonine kinase activity. Predicted to be involved in several processes, including DNA damage response; cellular response to oxidative stress; and regulation of signal transduction. Predicted to act upstream of or within protein autophosphorylation. Predicted to be located in endoplasmic reticulum membrane; mitochondrial membrane; and nuclear envelope. Predicted to be part of protein-containing complex. Predicted to be active in cytoplasm and nucleus. Orthologous to human VRK2 (VRK serine/threonine kinase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 86.8), Thymus (RPKM 61.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Vrk2 in Genome Data Viewer
    Location:
    14q22
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (104514815..104635549, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (100313771..100434520, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (110739835..110883836, complement)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene S100 calcium binding protein A11, pseudogene 2 Neighboring gene U1 spliceosomal RNA Neighboring gene FA complementation group L Neighboring gene uncharacterized LOC134481807 Neighboring gene uncharacterized LOC120096700 Neighboring gene heat shock protein family D (Hsp60) member 1, pseudogene 1 Neighboring gene uridine 5'-monophosphate synthase pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The vaccinia-related kinases phosphorylate the N' terminus of BAF, regulating its interaction with DNA and its retention in the nucleus. Nichols RJ, et al. Mol Biol Cell, 2006 May. PMID 16495336, Free PMC Article
    2. The subcellular localization of vaccinia-related kinase-2 (VRK2) isoforms determines their different effect on p53 stability in tumour cell lines. Blanco S, et al. FEBS J, 2006 Jun. PMID 16704422
    3. VRK2 inhibits mitogen-activated protein kinase signaling and inversely correlates with ErbB2 in human breast cancer. Fernández IF, et al. Mol Cell Biol, 2010 Oct. PMID 20679487, Free PMC Article
    4. Modulation of interleukin-1 transcriptional response by the interaction between VRK2 and the JIP1 scaffold protein. Blanco S, et al. PLoS One, 2008 Feb 20. PMID 18286207, Free PMC Article
    5. Vaccinia-related kinase 2 modulates the stress response to hypoxia mediated by TAK1. Blanco S, et al. Mol Cell Biol, 2007 Oct. PMID 17709393, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of interleukin-1-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein kinase VRK2
    Names
    vaccinia related kinase 2
    NP_001388334.1
    XP_038948163.1
    XP_063129480.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001401405.1 → NP_001388334.1  serine/threonine-protein kinase VRK2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/TrEMBL
      A0A0G2JVP1
      Related
      ENSRNOP00000069563.2, ENSRNOT00000086299.3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      104514815..104635549 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039092235.2 → XP_038948163.1  serine/threonine-protein kinase VRK2 isoform X1

      Conserved Domains (1) summary
      cl21453
      Location:1 → 196
      PKc_like; Protein Kinases, catalytic domain

    2. XM_063273410.1 → XP_063129480.1  serine/threonine-protein kinase VRK2 isoform X1

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001108366.1: Suppressed sequence

      Description
      NM_001108366.1: This RefSeq was removed because currently there is insufficient support for the transcript.
    Nucleotide Protein Strain
    Heading Accession and Version

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