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    Hfm1 helicase for meiosis 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 690161, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Hfm1provided by RGD
    Official Full Name
    helicase for meiosis 1provided by RGD
    Primary source
    RGD:1584010
    See related
    EnsemblRapid:ENSRNOG00000023299 AllianceGenome:RGD:1584010
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable DNA helicase activity. Predicted to be involved in resolution of meiotic recombination intermediates. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in primary ovarian insufficiency 9. Orthologous to human HFM1 (helicase for meiosis 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 20.4), Brain (RPKM 11.9) and 2 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Hfm1 in Genome Data Viewer
    Location:
    14p22
    Exon count:
    41
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (3002103..3108567)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (2857251..2943766)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (3879172..3961139)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene cell division cycle 7 Neighboring gene transmembrane protein 258 like 3 Neighboring gene uncharacterized LOC134481813 Neighboring gene uncharacterized LOC120096553 Neighboring gene uncharacterized LOC134481812 Neighboring gene uncharacterized LOC102551010

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Mouse HFM1/Mer3 is required for crossover formation and complete synapsis of homologous chromosomes during meiosis. Guiraldelli MF, et al. PLoS Genet, 2013 Mar. PMID 23555294, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA duplex unwinding IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in resolution of meiotic recombination intermediates IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within resolution of meiotic recombination intermediates ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    probable ATP-dependent DNA helicase HFM1
    Names
    HFM1, ATP-dependent DNA helicase homolog
    NP_001399493.1
    XP_008768170.1
    XP_017454874.1
    XP_038948406.1
    XP_038948407.1
    XP_063129719.1
    XP_063129720.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001412564.1 → NP_001399493.1  probable ATP-dependent DNA helicase HFM1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/TrEMBL
      F1LWY1
      Related
      ENSRNOP00000103638.1, ENSRNOT00000143122.1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      3002103..3108567
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017599385.3 → XP_017454874.1  probable ATP-dependent DNA helicase HFM1 isoform X1

      Related
      ENSRNOP00000103232.1, ENSRNOT00000151673.1
      Conserved Domains (3) summary
      cd00079
      Location:501 → 667
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      pfam00270
      Location:283 → 464
      DEAD; DEAD/DEAH box helicase
      pfam02889
      Location:775 → 1088
      Sec63; Sec63 Brl domain

    2. XM_063273649.1 → XP_063129719.1  probable ATP-dependent DNA helicase HFM1 isoform X2

    3. XM_008769948.4 → XP_008768170.1  probable ATP-dependent DNA helicase HFM1 isoform X3

      Related
      ENSRNOP00000034409.6, ENSRNOT00000033794.7
      Conserved Domains (3) summary
      cd00079
      Location:501 → 667
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      pfam00270
      Location:283 → 464
      DEAD; DEAD/DEAH box helicase
      pfam02889
      Location:775 → 1088
      Sec63; Sec63 Brl domain

    4. XM_063273650.1 → XP_063129720.1  probable ATP-dependent DNA helicase HFM1 isoform X5

    5. XM_039092478.2 → XP_038948406.1  probable ATP-dependent DNA helicase HFM1 isoform X4

      Conserved Domains (1) summary
      COG1204
      Location:2 → 579
      BRR2; Replicative superfamily II helicase [Replication, recombination and repair]

    6. XM_039092479.2 → XP_038948407.1  probable ATP-dependent DNA helicase HFM1 isoform X6

      Conserved Domains (1) summary
      pfam02889
      Location:48 → 361
      Sec63; Sec63 Brl domain

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001191101.1: Suppressed sequence

      Description
      NM_001191101.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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