Fcho1 FCH and mu domain containing endocytic adaptor 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Fcho1provided by RGD
Official Full Name: FCH and mu domain containing endocytic adaptor 1provided by RGD
Primary source: RGD:1307683
See related: EnsemblRapid:ENSRNOG00000033912 AllianceGenome:RGD:1307683
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable AP-2 adaptor complex binding activity. Predicted to be involved in several processes, including T cell receptor signaling pathway; clathrin coat assembly; and clathrin-dependent endocytosis. Is active in postsynaptic endocytic zone. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human FCHO1 (FCH and mu domain containing endocytic adaptor 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 158.0), Spleen (RPKM 82.2) and 2 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 16p14

Exon count:: 30

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	16	NC_086034.1 (18447424..18464738, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	16	NC_051351.1 (18413452..18430795, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	16	NC_005115.4 (20136008..20153344, complement)

Chromosome 16 - NC_086034.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables AP-2 adaptor complex binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in T cell receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in clathrin coat assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in clathrin coat assembly	ISO Inferred from Sequence Orthology more info
involved_in clathrin-dependent endocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in clathrin-dependent endocytosis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T cell activation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in clathrin-coated pit	IBA Inferred from Biological aspect of Ancestor more info
is_active_in clathrin-coated pit	ISO Inferred from Sequence Orthology more info
located_in clathrin-coated pit	ISO Inferred from Sequence Orthology more info
is_active_in clathrin-coated vesicle	IBA Inferred from Biological aspect of Ancestor more info
NOT located_in clathrin-coated vesicle	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic endocytic zone	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic endocytic zone	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: F-BAR domain only protein 1

Names: FCH domain only 1; FCH domain only protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001395712.1 → NP_001382641.1 F-BAR domain only protein 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000016

Related

ENSRNOP00000049715.6, ENSRNOT00000040464.6

Conserved Domains (3) summary

PHA03307
Location:303 → 595

PHA03307; transcriptional regulator ICP4; Provisional

cl10970
Location:620 → 880

AP_MHD_Cterm; C-terminal domain of adaptor protein (AP) complexes medium mu subunits and its homologs (MHD)

cl12013
Location:10 → 270

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086034.1 Reference GRCr8

Range

18447424..18464738 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017600027.3 → XP_017455516.1 F-BAR domain only protein 1 isoform X2

UniProtKB/TrEMBL

D3ZIM5

Conserved Domains (3) summary

PHA03307
Location:295 → 587

PHA03307; transcriptional regulator ICP4; Provisional

cl10970
Location:612 → 872

AP_MHD_Cterm; C-terminal domain of adaptor protein (AP) complexes medium mu subunits and its homologs (MHD)

cl12013
Location:10 → 270

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
XM_008771083.4 → XP_008769305.1 F-BAR domain only protein 1 isoform X2

See identical proteins and their annotated locations for XP_008769305.1

UniProtKB/TrEMBL

D3ZIM5

Related

ENSRNOP00000085471.2, ENSRNOT00000111337.2

Conserved Domains (3) summary

PHA03307
Location:295 → 587

PHA03307; transcriptional regulator ICP4; Provisional

cl10970
Location:612 → 872

AP_MHD_Cterm; C-terminal domain of adaptor protein (AP) complexes medium mu subunits and its homologs (MHD)

cl12013
Location:10 → 270

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
XM_006252864.5 → XP_006252926.1 F-BAR domain only protein 1 isoform X2

See identical proteins and their annotated locations for XP_006252926.1

UniProtKB/TrEMBL

D3ZIM5

Conserved Domains (3) summary

PHA03307
Location:295 → 587

PHA03307; transcriptional regulator ICP4; Provisional

cl10970
Location:612 → 872

AP_MHD_Cterm; C-terminal domain of adaptor protein (AP) complexes medium mu subunits and its homologs (MHD)

cl12013
Location:10 → 270

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
XM_006252865.5 → XP_006252927.1 F-BAR domain only protein 1 isoform X2

See identical proteins and their annotated locations for XP_006252927.1

UniProtKB/TrEMBL

D3ZIM5

Conserved Domains (3) summary

PHA03307
Location:295 → 587

PHA03307; transcriptional regulator ICP4; Provisional

cl10970
Location:612 → 872

AP_MHD_Cterm; C-terminal domain of adaptor protein (AP) complexes medium mu subunits and its homologs (MHD)

cl12013
Location:10 → 270

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
XM_039094302.2 → XP_038950230.2 F-BAR domain only protein 1 isoform X1
XM_039094306.2 → XP_038950234.1 F-BAR domain only protein 1 isoform X5

UniProtKB/TrEMBL

A6K9X9

Conserved Domains (1) summary

cl10970
Location:345 → 605

AP_MHD_Cterm; C-terminal domain of adaptor protein (AP) complexes medium mu subunits and its homologs (MHD)
XM_039094308.2 → XP_038950236.1 F-BAR domain only protein 1 isoform X7

UniProtKB/TrEMBL

A6K9X9

Conserved Domains (1) summary

cl10970
Location:257 → 517

AP_MHD_Cterm; C-terminal domain of adaptor protein (AP) complexes medium mu subunits and its homologs (MHD)
XM_039094309.2 → XP_038950237.1 F-BAR domain only protein 1 isoform X7

UniProtKB/TrEMBL

A6K9X9

Conserved Domains (1) summary

cl10970
Location:257 → 517

AP_MHD_Cterm; C-terminal domain of adaptor protein (AP) complexes medium mu subunits and its homologs (MHD)
XM_039094307.2 → XP_038950235.1 F-BAR domain only protein 1 isoform X6

UniProtKB/TrEMBL

A6K9X9

Conserved Domains (1) summary

cl10970
Location:270 → 530

AP_MHD_Cterm; C-terminal domain of adaptor protein (AP) complexes medium mu subunits and its homologs (MHD)
XM_039094304.2 → XP_038950232.1 F-BAR domain only protein 1 isoform X3

Conserved Domains (3) summary

PHA03307
Location:295 → 587

PHA03307; transcriptional regulator ICP4; Provisional

cl10970
Location:612 → 685

AP_MHD_Cterm; C-terminal domain of adaptor protein (AP) complexes medium mu subunits and its homologs (MHD)

cl12013
Location:10 → 270

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
XM_039094305.2 → XP_038950233.1 F-BAR domain only protein 1 isoform X4

Conserved Domains (3) summary

PHA03307
Location:295 → 587

PHA03307; transcriptional regulator ICP4; Provisional

cl10970
Location:612 → 682

AP_MHD_Cterm; C-terminal domain of adaptor protein (AP) complexes medium mu subunits and its homologs (MHD)

cl12013
Location:10 → 270

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

RNA

XR_005494564.2 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001106069.1: Suppressed sequence

Description

NM_001106069.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.