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    Mfap3l microfibril associated protein 3 like [ Rattus norvegicus (Norway rat) ]

    Gene ID: 306424, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mfap3lprovided by RGD
    Official Full Name
    microfibril associated protein 3 likeprovided by RGD
    Primary source
    RGD:1311274
    See related
    EnsemblRapid:ENSRNOG00000011775 AllianceGenome:RGD:1311274
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be located in several cellular components, including cell junction; nucleoplasm; and plasma membrane. Orthologous to human MFAP3L (microfibril associated protein 3 like). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 262.4), Testes (RPKM 248.0) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mfap3l in Genome Data Viewer
    Location:
    16p12
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (34422490..34465544, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (29411643..29454665, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (32734059..32777091, complement)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene peptidylprolyl cis/trans isomerase, NIMA-interacting 1, pseudogene 1 Neighboring gene peptidylprolyl isomerase A, pseudogene 13 Neighboring gene aminoadipate aminotransferase Neighboring gene uncharacterized LOC134478862 Neighboring gene ribosomal protein L18, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. MFAP3L activation promotes colorectal cancer cell invasion and metastasis. Lou X, et al. Biochim Biophys Acta, 2014 Sep. PMID 24735981
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    located_in cell junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    microfibrillar-associated protein 3-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012049.1 → NP_001012049.1  microfibrillar-associated protein 3-like precursor

      See identical proteins and their annotated locations for NP_001012049.1

      Status: PROVISIONAL

      Source sequence(s)
      BC078969
      UniProtKB/Swiss-Prot
      Q6AYP2
      UniProtKB/TrEMBL
      A6KIT3
      Related
      ENSRNOP00000015759.3, ENSRNOT00000015759.6
      Conserved Domains (2) summary
      smart00410
      Location:55 → 142
      IG_like; Immunoglobulin like
      cd00096
      Location:64 → 68
      Ig; Ig strand B [structural motif]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      34422490..34465544 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017600107.3 → XP_017455596.1  microfibrillar-associated protein 3-like isoform X1

      UniProtKB/Swiss-Prot
      Q6AYP2
      UniProtKB/TrEMBL
      A6KIT3
      Conserved Domains (2) summary
      smart00410
      Location:55 → 142
      IG_like; Immunoglobulin like
      cd00096
      Location:64 → 68
      Ig; Ig strand B [structural motif]

    2. XM_039094498.2 → XP_038950426.1  microfibrillar-associated protein 3-like isoform X2

      UniProtKB/TrEMBL
      A6KIT4
      Conserved Domains (2) summary
      cd00096
      Location:1 → 4
      Ig; Ig strand D [structural motif]
      cl11960
      Location:1 → 39
      Ig; Immunoglobulin domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6AYP2.1 GenPept UniProtKB/Swiss-Prot:Q6AYP2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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