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    Kif27 kinesin family member 27 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 246209, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Kif27provided by RGD
    Official Full Name
    kinesin family member 27provided by RGD
    Primary source
    RGD:621071
    See related
    EnsemblRapid:ENSRNOG00000019257 AllianceGenome:RGD:621071
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Krp5
    Summary
    Predicted to enable ATP hydrolysis activity; microtubule binding activity; and microtubule motor activity. Predicted to be involved in cilium assembly and microtubule-based movement. Predicted to act upstream of or within epithelial cilium movement involved in extracellular fluid movement; establishment of localization in cell; and ventricular system development. Predicted to be located in cilium. Predicted to be part of kinesin complex. Predicted to be active in cytoplasm and microtubule. Orthologous to human KIF27 (kinesin family member 27). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 128.2), Kidney (RPKM 17.2) and 2 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Kif27 in Genome Data Viewer
    Location:
    17p14
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (6304960..6383745)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (6299544..6375106)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (6701287..6776599)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene heterogeneous nuclear ribonucleoprotein K Neighboring gene microRNA 7-1 Neighboring gene Q-nucleotide N-glycosylase 1 Neighboring gene kinesin family member 27 like 1 Neighboring gene uncharacterized LOC134482805 Neighboring gene G kinase anchoring protein 1 Neighboring gene small nucleolar RNA SNORD113/SNORD114 family

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Kinesin-related proteins in the mammalian testes: candidate motors for meiosis and morphogenesis. Sperry AO, et al. Mol Biol Cell, 1996 Feb. PMID 8688559, Free PMC Article
    2. Gene discovery in the hamster: a comparative genomics approach for gene annotation by sequencing of hamster testis cDNAs. Oduru S, et al. BMC Genomics, 2003 Jun 3. PMID 12783626, Free PMC Article
    3. Fused has evolved divergent roles in vertebrate Hedgehog signalling and motile ciliogenesis. Wilson CW, et al. Nature, 2009 May 7. PMID 19305393, Free PMC Article
    4. Congenital hydrocephalus in genetically engineered mice. Vogel P, et al. Vet Pathol, 2012 Jan. PMID 21746835
    5. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microtubule motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cilium assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within epithelial cilium movement involved in extracellular fluid movement ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within establishment of localization in cell ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in microtubule-based movement IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule-based movement IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within ventricular system development ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cilium ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of kinesin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    kinesin-like protein KIF27
    Names
    kinesin-related protein KIF27A
    kinesin-related protein KRP5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_198050.1 → NP_932167.1  kinesin-like protein KIF27

      See identical proteins and their annotated locations for NP_932167.1

      Status: PROVISIONAL

      Source sequence(s)
      BK001053
      UniProtKB/Swiss-Prot
      Q7M6Z5
      UniProtKB/TrEMBL
      A6KAK4
      Related
      ENSRNOP00000026054.5, ENSRNOT00000026054.6
      Conserved Domains (4) summary
      smart00129
      Location:5 → 348
      KISc; Kinesin motor, catalytic domain. ATPase
      COG0419
      Location:702 → 1222
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd01372
      Location:4 → 342
      KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
      pfam13863
      Location:789 → 884
      DUF4200; Domain of unknown function (DUF4200)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      6304960..6383745
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006253556.5 → XP_006253618.1  kinesin-like protein KIF27 isoform X1

      See identical proteins and their annotated locations for XP_006253618.1

      UniProtKB/Swiss-Prot
      Q7M6Z5
      UniProtKB/TrEMBL
      A6KAK4
      Conserved Domains (4) summary
      smart00129
      Location:5 → 348
      KISc; Kinesin motor, catalytic domain. ATPase
      COG0419
      Location:702 → 1222
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd01372
      Location:4 → 342
      KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
      pfam13863
      Location:789 → 884
      DUF4200; Domain of unknown function (DUF4200)

    2. XM_006253557.5 → XP_006253619.1  kinesin-like protein KIF27 isoform X2

      UniProtKB/TrEMBL
      A0A8L2R9D5, A6KAK4
      Related
      ENSRNOP00000074434.2, ENSRNOT00000080683.3
      Conserved Domains (4) summary
      smart00129
      Location:5 → 348
      KISc; Kinesin motor, catalytic domain. ATPase
      COG0419
      Location:654 → 1174
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd01372
      Location:4 → 342
      KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
      pfam13863
      Location:741 → 836
      DUF4200; Domain of unknown function (DUF4200)

    3. XM_063276058.1 → XP_063132128.1  kinesin-like protein KIF27 isoform X1

      UniProtKB/Swiss-Prot
      Q7M6Z5
      UniProtKB/TrEMBL
      A6KAK4

    4. XM_063276059.1 → XP_063132129.1  kinesin-like protein KIF27 isoform X3

      UniProtKB/TrEMBL
      A6KAK4

    5. XM_063276057.1 → XP_063132127.1  kinesin-like protein KIF27 isoform X1

      UniProtKB/Swiss-Prot
      Q7M6Z5
      UniProtKB/TrEMBL
      A6KAK4

    RNA

    1. XR_360722.5 RNA Sequence

    2. XR_360721.5 RNA Sequence

    3. XR_010058809.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7M6Z5.1 GenPept UniProtKB/Swiss-Prot:Q7M6Z5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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