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    Adad1 adenosine deaminase domain containing 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 294979, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Adad1provided by RGD
    Official Full Name
    adenosine deaminase domain containing 1provided by RGD
    Primary source
    RGD:1359309
    See related
    EnsemblRapid:ENSRNOG00000017246 AllianceGenome:RGD:1359309
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Tenr
    Summary
    Predicted to enable double-stranded RNA adenosine deaminase activity; double-stranded RNA binding activity; and tRNA-specific adenosine deaminase activity. Predicted to be involved in RNA processing; adenosine to inosine editing; and spermatid development. Predicted to be located in male germ cell nucleus. Predicted to be active in cytoplasm and nucleolus. Orthologous to human ADAD1 (adenosine deaminase domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 264.1) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Adad1 in Genome Data Viewer
    Location:
    2q25
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (121872387..121935721)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (119948809..120005920)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (123790798..123848598)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L7, pseudogene 22 Neighboring gene bridge-like lipid transfer protein family member 1 Neighboring gene THUMP domain containing 1, pseudogene 1 Neighboring gene interleukin 2 Neighboring gene interleukin 21 Neighboring gene centrin 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Disruption of murine Tenr results in teratospermia and male infertility. Connolly CM, et al. Dev Biol, 2005 Feb 1. PMID 15649457
    2. Distribution of Tenr, an RNA-binding protein, in a lattice-like network within the spermatid nucleus in the mouse. Schumacher JM, et al. Biol Reprod, 1995 Jun. PMID 7543294
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC94331, MGC124895

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables adenosine deaminase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables double-stranded RNA adenosine deaminase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables double-stranded RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tRNA-specific adenosine deaminase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in RNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in adenosine to inosine editing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    NOT acts_upstream_of_or_within regulation of translation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in spermatid development IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within spermatid development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in spermatid development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in spermatid development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in male germ cell nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in male germ cell nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    adenosine deaminase domain-containing protein 1
    Names
    adenosine deaminase domain containing 1 (testis specific)
    testis nuclear RNA-binding protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001006977.2 → NP_001006978.2  adenosine deaminase domain-containing protein 1

      See identical proteins and their annotated locations for NP_001006978.2

      Status: VALIDATED

      Source sequence(s)
      BC083595, CV126304
      UniProtKB/Swiss-Prot
      Q3KR54
      Conserved Domains (2) summary
      cd19905
      Location:137 → 205
      DSRM_ADAD1; double-stranded RNA binding motif of adenosine deaminase domain-containing protein 1 (ADAD1) and similar proteins
      pfam02137
      Location:291 → 611
      A_deamin; Adenosine-deaminase (editase) domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      121872387..121935721
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063281569.1 → XP_063137639.1  adenosine deaminase domain-containing protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8L2QBZ2

    2. XM_006232278.5 → XP_006232340.1  adenosine deaminase domain-containing protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8L2QBZ2
      Related
      ENSRNOP00000023282.5, ENSRNOT00000023282.8
      Conserved Domains (2) summary
      smart00358
      Location:139 → 204
      DSRM; Double-stranded RNA binding motif
      pfam02137
      Location:291 → 611
      A_deamin; Adenosine-deaminase (editase) domain

    3. XM_063281570.1 → XP_063137640.1  adenosine deaminase domain-containing protein 1 isoform X3

    4. XM_006232279.5 → XP_006232341.1  adenosine deaminase domain-containing protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A0G2K1X9
      Related
      ENSRNOP00000111724.1, ENSRNOT00000169291.1
      Conserved Domains (2) summary
      smart00358
      Location:112 → 177
      DSRM; Double-stranded RNA binding motif
      pfam02137
      Location:264 → 584
      A_deamin; Adenosine-deaminase (editase) domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3KR54.1 GenPept UniProtKB/Swiss-Prot:Q3KR54

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