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    Fcgr1a Fc gamma receptor 1A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 295279, updated on 9-Dec-2024

    Summary

    Official Symbol
    Fcgr1aprovided by RGD
    Official Full Name
    Fc gamma receptor 1Aprovided by RGD
    Primary source
    RGD:1309912
    See related
    EnsemblRapid:ENSRNOG00000021199 AllianceGenome:RGD:1309912
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Fcgr1; Fcgr1b; FcgammaRI
    Summary
    Enables leukotriene receptor binding activity. Involved in several processes, including positive regulation of phagocytosis, engulfment; response to aldosterone; and response to estradiol. Predicted to be located in plasma membrane. Predicted to be active in external side of plasma membrane. Biomarker of retinal degeneration. Orthologous to several human genes including FCGR1A (Fc gamma receptor Ia). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 177.3), Lung (RPKM 93.7) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Fcgr1a in Genome Data Viewer
    Location:
    2q34
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (186539941..186548941, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (183851075..183860077, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (198430536..198439453, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene histone cluster 2 H3 family member C2 Neighboring gene H2B clustered histone 18 Neighboring gene uncharacterized LOC134485653 Neighboring gene mitochondrial import inner membrane translocase subunit TIM14-like Neighboring gene transfer RNA glycine (anticodon CCC) 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables IgG binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables IgG binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables IgG receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables IgG receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables high-affinity IgG receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables leukotriene receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in Fc-gamma receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in antibody-dependent cellular cytotoxicity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within antibody-dependent cellular cytotoxicity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in antibody-dependent cellular cytotoxicity ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within antigen processing and presentation of exogenous antigen ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within antigen processing and presentation of exogenous peptide antigen via MHC class I ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell surface receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within cell surface receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within defense response to bacterium ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within phagocytosis, engulfment ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within phagocytosis, recognition ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of phagocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within positive regulation of phagocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of phagocytosis, engulfment IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of tumor necrosis factor production IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within positive regulation of type III hypersensitivity ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of type IIa hypersensitivity ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within receptor-mediated endocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of immune response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to aldosterone IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    acts_upstream_of_or_within response to bacterium ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to epinephrine IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to estradiol IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in external side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    high affinity immunoglobulin gamma Fc receptor I
    Names
    Fc fragment of IgG high affinity Ib receptor
    Fc fragment of IgG receptor Ia
    Fc fragment of IgG, high affinity Ia, receptor (CD64)
    Fc fragment of IgG, high affinity Ib, receptor for (CD64)
    Fc gamma receptor Ia
    Fc receptor, IgG, high affinity I
    high affinity IgG Fc receptor, subunit beta
    high-affinity immunoglobulin gamma Fc receptor I

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100836.1NP_001094306.1  high affinity immunoglobulin gamma Fc receptor I precursor

      See identical proteins and their annotated locations for NP_001094306.1

      Status: PROVISIONAL

      Source sequence(s)
      AA859169, CF113031, CO555980
      UniProtKB/TrEMBL
      A0A0B4J2J0, A6K367
      Related
      ENSRNOP00000028780.4, ENSRNOT00000028780.6
      Conserved Domains (3) summary
      smart00410
      Location:115184
      IG_like; Immunoglobulin like
      pfam00047
      Location:201266
      ig; Immunoglobulin domain
      cl11960
      Location:104184
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      186539941..186548941 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039102048.2XP_038957976.1  high affinity immunoglobulin gamma Fc receptor I isoform X1

      Conserved Domains (3) summary
      pfam00047
      Location:111176
      ig; Immunoglobulin domain
      cd00096
      Location:1418
      Ig; Ig strand A [structural motif]
      cl11960
      Location:1494
      Ig; Immunoglobulin domain

    RNA

    1. XR_005500264.2 RNA Sequence